Pharmacokinetic Drug–Drug Interactions: An Insight into Recent Us Fda-Approved Drugs for Prostate Cancer

Abstract

Pharmacokinetic drug–drug interaction is a significant safety and efficiency concern as it results in considerable concentration changes. Drug–drug interactions are a substantial concern in anticancer drugs that possess a narrow therapeutic index. These interactions remain as the principal regulatory obstacle that can lead to termination in the preclinical stage, restrictions in the prescription, dosage adjustments or withdrawal of the drugs from the market. Drug metabolizing enzymes or transporters mediate the majority of clinically relevant drug interactions. Cancer diagnosed aged patients use multiple medications and are more prone to significant drug–drug interactions. This review provides detailed information on clinically relevant drug–drug interactions resulting from drug metabolism by enzymes and transporters with a particular emphasis on recent FDA approved antiprostate cancer drugs.

Graphical abstract

Keywords:

• combination therapy
• CYP enzymes
• drug–drug interactions
• prostate cancer
• transporters

Acknowledgments

The authors are grateful to the Department of Pharmaceuticals, Ministry of Chemicals & Fertilizers, Government of India, New Delhi, for the award of the NIPER fellowship. The manuscript bears the NIPER-Hyderabad communication number NIPER-H/2020/081.

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.