Oral Fluid for The Detection of Drugs of Abuse Using Immunoassay and LC–MS/MS

Abstract

The utility of oral fluid as a sample matrix for the analysis of drugs has been increasing in popularity over the last few years. This is largely because of collection advantages over other matrices, but also due to the rapid improvements in analytical assays including highly sensitive liquid reagent format enzyme immunoassays and LC–MS/MS. This review will highlight improvements in assay formats, sensitivity, laboratory equipment and sample processing using low sample volumes to expand drug test profiles.

Financial & competing interests disclosure

C Moore is employed by Immunalysis Corporation, which manufactures the Quantisal™ oral fluid collection device and immunoassay reagents for oral fluid analysis. D Crouch is a Consultant for Immunalysis Corporation. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.