https://orcid.org/0000-0002-7788-5519
Abstract
Signal transducers and activators of transcription 6 (STAT6) are highly expressed in various tumors and associated with tumorigenesis, immunosuppression, proliferation, metastasis and poor prognosis in human cancers. In response to IL-4/13, STAT6 is phosphorylated, dimerizes and triggers transcriptional regulation after recruitment of coactivators to transcriptosome, such as CBP/p300, SRC-1, PARP-14 and PSF. Post-translational modifications, including phosphorylation, ubiquitination, ADP-ribosylation and acetylation, have been explored for molecular mechanisms of STAT6 in tumor development and management. STAT6 has been developed as a specific biomarker for distinguishing and diagnosing tumor phenotypes, although it is observed to be frequently mutated in metastatic tumors. In this article, we focus mainly on the structural characteristics of STAT6 and its role in tumor growth and progression.
Financial & competing interests disclosure
This study was supported by the National Natural Science Foundation of China under grants 81660595, 81660371, 81860388, 81860261 and 81960883; the Scientific Research Fund of Jiangxi Provincial Education Department (no. GJJ190789, GJJ190791 and GJJ190824), the Youth Jinggang Scholar Program in Jiangxi Province and the Innovative Teamwork Project of Gannan Medical University under grant TD201707. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.