Abstract
Background: Diabetes mellitus is a serious global health concern, and this is expected to impact more than 300 million people by 2025. The current study focuses on identifying substituted indolin-2-one-based inhibitors for two indispensable drug targets, α-amylase and α-glucosidase. Methods: The structures of synthetic compounds were confirmed by spectroscopic techniques and evaluated for enzyme inhibition activities. Kinetic and in silico studies were also performed. Results: All compounds exhibited good-to-moderate inhibitory potential. Most importantly, compounds 1, 2, 6, 16 and 17 were identified as potent α-glucosidase inhibitors (IC50 = 9.15 ± 0.12–13.74 ± 0.12 μM). Conclusion: This study identified that these synthetic compounds might serve as potential lead molecules for antidiabetic agents.
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Supplementary data
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Financial & competing interests disclosure
The authors would like to acknowledge the financial support of the Sindh Higher Education Commission (SHEC), Sindh, Pakistan, vide letter no. NO.DD/SHEC/1-14/2014, project code SHEC/SRSP/Med-3/15/2021-2. The author IG Asuquo would like to acknowledge The World Academy of Sciences (TWAS) and the International Center for Chemical and Biological Sciences, University of Karachi, Pakistan, for sponsoring the research through the ICCBS-TWAS Sandwich Postgraduate Fellowship Award 2019 (FR number # 3240311207). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.