Novel 2-Indolinone Derivatives as Promising Agents against Respiratory Syncytial and Yellow Fever Viruses

Abstract

Background: A vaccine or antiviral drug for respiratory syncytial virus (RSV) infections and a specific antiviral drug for yellow fever virus (YFV) infections has not yet been developed. Method: In this study, 2-indolinone-based N-(4-sulfamoylphenyl)hydrazinecarbothioamides were synthesized. Along with these new compounds, previously synthesized 2-indolinone-based N-(3-sulfamoylphenyl)hydrazinecarbothioamides were evaluated against various DNA and RNA viruses. Results: Some 2-indolinone compounds exhibited nontoxic and selective antiviral activities against RSV and YFV. Halogen substitution at the indole ring increased the anti-RSV activities. Moreover, 1-benzyl and 5-halogen or nitro-substituted compounds were the most effective compounds against YFV. Conclusion: Generally, the 3-sulfonamide-substituted compounds were determined to be more effective than 4-sulfonamide-substituted compounds against RSV and YFV.

Keywords::

• 2-indolinone
• antiviral activity
• respiratory syncytial virus
• sulfonamide
• yellow fever virus

Supplementary data

To view the supplementary data that accompany this paper please visit the journal website at: www.future-science.com/doi/suppl/10.4155/fmc-2023-0179

Author contributions

Concept: Ç Apaydın, F Göktaş, L Naesens and N Karalı; design: Ç Apaydın, L Naesens and N Karalı; supervision: L Naesens and N Karalı; resources: L Naesens and N Karalı; materials: L Naesens and N Karalı; data collection and/or processing: Ç Apaydın and F Göktaş; analysis and/or interpretation: Ç Apaydın, F Göktaş, L Naesens and N Karalı; literature search: Ç Apaydın, F Göktaş, L Naesens and N Karalı; writing: Ç Apaydın, F Göktaş, L Naesens and N Karalı; critical reviews: Ç Apaydın, L Naesens and N Karalı.

Acknowledgments

L Naesens wishes to thank L Persoons and coworkers for technical assistance.

Financial disclosure

This work was supported by The Scientific Research Projects Coordination Unit of Istanbul University (TSG-2018-27798). The authors have no other financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Competing interests disclosure

The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Writing disclosure

No writing assistance was utilized in the production of this manuscript.

Additional information

Funding

This work was supported by The Scientific Research Projects Coordination Unit of Istanbul University (TSG-2018-27798). The authors have no other financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.