Synthesis of Ring-Substituted N-Benzyl γ-Phenyl Gaba Derivatives Via Reductive Amination

Abstract

Background: GABA derivatives are important for the development of drugs for disorders of the CNS and PNS. Results: We describe a simple synthesis of N-benzyl γ-phenyl-γ-aminobutyric acids, via the reductive amination of the corresponding γ-keto acids with benzylamines using ammonia borane. Conclusion: This procedure provides an efficient and economical method for the synthesis of GABA derivatives.

Financial & competing interests disclosure

Financial support for this project from the Herbert C Brown Center for Borane Research is gratefully acknowledged. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Additional information

Funding

Financial support for this project from the Herbert C Brown Center for Borane Research is gratefully acknowledged. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.