Nanomaterials: an intra-periodontal Pocket drug-delivery System for Periodontitis

Abstract

Periodontitis is a microbiological condition that affects the tissues supporting the teeth. The fundamental to effective periodontal therapy is choosing the suitable antimicrobial and anti-inflammatory agent, together with the proper route of drug administration and delivery system. Intra-periodontal pocket approach with nano drug-delivery systems (NDDS) such as polymeric nanoparticles, gold nanoparticles, silica nanoparticles, magnetic nanoparticles, liposomes, polymersomes, exosomes, nano micelles, niosome, solid lipid nanoparticles, nano lipid carriers, nanocomposites, nanogels, nanofibers, scaffolds, dendrimers, quantum dots, etc., will be appropriate route of drug administration and delivery system. This NDDS delivers the drugs at the site of infection to inhibit growth and promote tissue regeneration. The present review focused on providing comprehensive information on the NDDS for periodontitis, which enhanced therapeutic outcomes via intra-periodontal pocket delivery.

Plain language summary

Periodontitis is a problem that can make your teeth fall out. It happens when the tissues that hold your teeth start to break down. Scientists have found a way to help treat it by using tiny things called ‘nano drug-delivery systems’ or NDDS. These NDDS carry medicine to the infected area and stop the germs from growing. They can also help the tissue around your teeth to heal. Some examples of NDDS are liposomes, polymersomes, exosomes, nanomicelles, and more. Regular treatment with antibiotics may not work as well as NDDS. Using NDDS can make a big difference in how well your teeth and gums heal. In the future, scientists hope to use NDDS to prevent the problem from coming back. This new way of treating periodontitis could be a big help for people with this problem.

Tweetable abstract

The nano drug-delivery system improves the targeting efficacy along with inhibition of microbial growth and initiates the tissue regeneration upon intra-periodontal delivery.

Graphical abstract

Keywords:

• anti-inflammatory
• antimicrobial
• intra-periodontal pocket administration
• nano drug-delivery system
• periodontitis

Author contributions

Conceptualization – Nethish RK and SC Nair. Methodology – Nethish RK. Writing – original draft: Nethish RK. Writing – review & editing: Nethish RK. Supervision – SC Nair.

Acknowledgments

We would like to express our sincere gratitude to Sabitha M, Principal, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, for all the guidance and support.

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.