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Abstract
Implantable drug-delivery systems provide new means for achieving therapeutic drug concentrations over entire treatment durations in order to optimize drug action. This article focuses on new drug administration modalities achieved using implantable drug-delivery systems that are enabled by micro- and nano-fabrication technologies, and microfluidics. Recent advances in drug administration technologies are discussed and remaining challenges are highlighted.
Financial & competing interests disclosure
The authors acknowledge the NIH (R21EY018490, R21DA026970 and R01NS050171), Qualcomm/TATRC Wireless Health Innovation Challenge and Wallace H Coulter Foundation for financial support. The authors have a financial interest in Fluid Synchrony LLC (Alhambra, CA, USA). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.