Research Spotlight: Delivery of custom-purposed Colloidal Nanocrystals to Cancer Cells

Abstract

Colloidal inorganic nanocrystals are abound with magnetic, luminescent and plasmonic properties that are attractive for medical diagnostics and therapy. Our group, among others, have been interested in conferring nanocrystals, by design, with new capabilities that are not possible with conventional materials approaches. Two areas where the fruits of these efforts are paying dividends are in their implementation as in vivo imaging probes and as biosensors that dynamically respond to the local chemical or physical environment in cells and tissues. For applications in medical imaging, nanocrystal probes with unusual shapes are showing exceptional promise over existing technologies, while for environment-responsive probes, a hybrid approach involving tailored organic coatings is being implemented alongside the nanocrystals for the realization of dynamic, information-rich optical outputs.

Financial & competing interests disclosure

The work of BA Helms, MJ Bailey and JT Duong at the Molecular Foundry was supported by the Office of Science, Office of Basic Energy Sciences, of the US Department of Energy under Contract No. DE-AC02-05CH11231. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.