Generation of Tailored Aerosols for Inhalative Drug Delivery Employing Recent Vibrating-Mesh Nebulizer Systems

Abstract

Direct drug delivery to the lungs is considered the gold standard for the treatment of a variety of respiratory diseases, owing to the increased therapeutic selectivity of the inhalative approach. Airborne formulations with defined size characteristics are required to improve the deposition pattern within the airways. In this respect, different nebulizer systems have been conceived, which has enabled the generation of respirable medicament mists. Here, vibrating-mesh technology revealed significant potential to overcome the main shortcomings associated with ‘traditional’ devices. Tailored orifice dimensions and defined formulation characteristics are of special interest for the generation of suitable aerosol droplets for inhalative purposes. Ongoing developments in device and formulation design will optimize the clinical outcome of inhalative drug delivery under application of vibrating-mesh technology.

Acknowledgements

The authors are grateful to the Danish Council for Independent Research and the Deutsche Forschungsgemeinschaft (BE 5308/1-1) for financial support.

Disclaimer

The funding sources had no involvement in the manuscript design, in the collection, analysis and interpretation of existing data, in the writing of the manuscript, or in the decision to submit the article draft for publication.

Financial & competing interests disclosure

The Danish Council for Independent Research and the Deutsche Forschungsgemeinschaft (BE 5308/1-1) provided financial support for the conduct of this work. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.