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OncoImmunology Volume 1, 2012 - Issue 1
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CCR5 in cancer immunotherapy: More than an “attractive” receptor for T cells

Alicia González-Martín Department of Immunology and Oncology; Centro Nacional de Biotecnología CNB/CSIC; Darwin 3; Campus Cantoblanco; Madrid, Spain
,
Emilia Mira Department of Immunology and Oncology; Centro Nacional de Biotecnología CNB/CSIC; Darwin 3; Campus Cantoblanco; Madrid, Spain
&
Santos Mañes Department of Immunology and Oncology; Centro Nacional de Biotecnología CNB/CSIC; Darwin 3; Campus Cantoblanco; Madrid, SpainCorrespondence[email protected]
Pages 106-108 | Received 02 Sep 2011, Accepted 06 Sep 2011, Published online: 01 Jan 2012
 
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Abstract

Despite intensive study, the role of CCR5 in cancer remains elusive. We showed that CCR5 expression by both CD4+ and CD8+ T cells is necessary to boost anti-tumor responses by optimizing helper-dependent CD8+ T cell priming. Our findings could have implications for cancer treatment in patients with defective CCR5 expression.

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