Biological Screening of a Novel Nickel (II) Tyrosine Complex

Abstract

A newly synthesized Nickel (II) tyrosine complex was screened as potential antimicrobial agent against a number of medically important bacteria (Bacillus subtilis, Streptococcus β-haemolytica, Escherichia coli, Shigella dysenterae) and fungi (Aspergillus fumigatus, Candida albicans, Aspergillus niger, Aspergillus flavus, Penicillium sp.) strains, were used for antifungal activity. The antimicrobial activity was evaluated using the Agar Disc method. Moreover, the minimum inhibitory concentration of the complexes was determined against the same pathogenic bacteria and the values were found between 4~64 μg ml⁻¹. Brine shrimp bioassay was carried out for cytotoxicity measurements of the complexes. The LC₅₀ values were calculated after probit transformation of the resulting mortality data and found to be 6 μg ml⁻¹.

Keywords::

• Antimicrobial activity
• Cytotoxicity
• Nickel (U) tyrosine complex
• Pathogens