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Original Papers

Is There any Association Between Nesfatin-1 and Generalized Anxiety Disorder?

Nesfatin-1 ve yaygın anksiyete bozukluğu arasında ilişki var mı?

, , , , MD, , MD, , PhD. & show all
Pages 55-58 | Received 19 Feb 2013, Accepted 21 Apr 2013, Published online: 08 Nov 2016
 

ABSTRACT

Objective: The aim of the present study was to find out the possible role of nesfatin-1 in the pathogenesis of generalized anxiety disorder (GAD).

Methods: In this study, we measured plasma nesfatin-1 levels in 40 GAD patients and 42 controls that were matched by age and BMI. The severity of anxiety was evaluated with the Hamilton Anxiety Rating Scale (HAM-A).

Results: There was no statistically significant difference in the nesfatin-1 levels between patient and control groups. The mean serum nesfatin-1 level did not show any correlation with age, duration of illness, BMI, HAM-A scores in the patient and control groups.

Conclusion: Our results do not support that nesfatin-1 is associated with GAD.

ÖZET

Amaç: Bu çalışmanın amacı yaygın anksiyete bozukluğu (YAB)'nun patogenezinde nesfatin-1′in olası rolünü araştırmaktır.

Yöntem: Bu çalışmada 40 YAB'lu hasta ile yaş ve BMI ile eşleştirilmiş 42 sağlıklı kontrol'un plasma nesfatin-1 düzeyleri ölçüldü. Anksiyete şiddeti Hamilton Anksiyete Derecelendirme Ölçeği (HAM-A) ile değerlendirildi.

Bulgular: Hasta ve kontrol grupları arasında nesfatin-1 düzeyinde anlamlı bir farklılık yoktur. Ortalama serum nesfatin-1 düzeyi yaş, hastalık süresi, BMI ve HAM-A skoru ile korelasyon göstermiyordu.

Sonuç: Sonuçlarımız YAB'nun nesfatin-1 ile ilişkili olduğunu desteklemiyor.

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