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ABSTRACT
Aminophosphonates, as structural analogues of natural α- aminocarboxylic acids, constitute a valuable class of compounds with a wide spectrum of biological activity, including treatment of metabolic disorders and cancer. A recently synthesized furan-bearing aminophosphonate, namely N,N-dimethyl-[N'-methyl(diethoxyphosphonyl)-(2-furyl)]-1,3-diaminopropane was tested for in vitro antitumor activity on six human epithelial cancer cell lines. Safety testing of the compound was performed both in vitro (3T3 NRU test) and in vivo on ICR mice for genotoxicity and antiproliferative activity. The tested aminophosphonate showed high in vitro antitumor activity towards HepG2 cell line (human hepatocellular carcinoma) and 647-V cell line (human bladder carcinoma). In addition, this furan-containing aminophosphonate had a moderate genotoxic and antiproliferative activity in vivo and exhibited complete absence of toxicity to Balb/c 3T3 (clone 31) mouse embryo cells.