423
Views
5
CrossRef citations to date
0
Altmetric
Review Article

Targeting the orexinergic system: Mainly but not only for sleep-wakefulness therapiesFootnoteFootnote

&
Pages 279-286 | Received 12 Jun 2014, Accepted 20 Jul 2014, Published online: 17 May 2019

References

  • L.de LeceaT.S.KilduffC.PeyronThe hypocretins: hypothalamus-specific peptides with neuroexcitatory activityProc Natl Acad Sci U S A951998322327
  • T.SakuraiA.AmemiyaM.IshiiOrexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviorCell921998573585
  • M.MiedaT.SakuraiOrexin (Hypocretin) receptor agonists and antagonists for treatment of sleep disorders: rationale for development and current statusCNS Drugs2013
  • T.SakuraiA.AmemiyaM.IshiiOrexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviorCell921998 1 page following 696
  • T.HolmqvistK.E.AkermanJ.P.KukkonenOrexin signaling in recombinant neuron-like cellsFEBS Lett52620021114
  • N.I.CataldiV.A.Lux-LantosC.LibertunEffects of orexins A and B on expression of orexin receptors and progesterone release in luteal and granulosa ovarian cellsRegul Pept17820125663
  • K.KirszM.SzczesnaE.MolikT.MisztalA.K.WojtowiczD.A.ZiebaSeasonal changes in the interactions among leptin, ghrelin, and orexin in sheepJ Anim Sci90201225242531
  • Y.ZhuY.MiwaA.YamanakaOrexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteinsJ Pharmacol Sci922003259266
  • A.GhanemiL.HeM.YanNew factors influencing G protein coupled receptors’ system functionsAlexandria J Med49201315
  • A.GhanemiTargeting G protein coupled receptor-related pathways as emerging molecular therapiesSaudi Pharm J2013
  • J.P.KukkonenPhysiology of the orexinergic/hypocretinergic system: a revisit in 2012Am J Physiol Cell Physiol3042013C2C32
  • M.H.JanttiJ.PutulaP.SomerharjuM.A.FrohmanJ.P.KukkonenOX1 orexin/hypocretin receptor activation of phospholipase DBr J Pharmacol165201211091123
  • A.UrbanskaP.SokolowskaA.Woldan-TamborOrexins/hypocretins acting at Gi protein-coupled OX 2 receptors inhibit cyclic AMP synthesis in the primary neuronal culturesJ Mol Neurosci MN4620121017
  • M.A.SteinerH.LecourtF.JenckThe dual orexin receptor antagonist almorexant, alone and in combination with morphine, cocaine and amphetamine, on conditioned place preference and locomotor sensitization in the ratInt JNeuropsychopharmacol162013417432
  • R.M.ChemelliJ.T.WillieC.M.SintonNarcolepsy in orexin knockout mice: molecular genetics of sleep regulationCell981999437451
  • L.LinJ.FaracoR.LiThe sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 geneCell981999365376
  • S.NishinoB.RipleyS.OvereemG.J.LammersE.MignotHypocretin (orexin) deficiency in human narcolepsyLancet35520003940
  • C.J.WinrowA.L.GotterC.D.CoxPharmacological characterization of MK-6096 - a dual orexin receptor antagonist for insomniaNeuropharmacology622012978987
  • C.Brisbare-RochJ.DingemanseR.KobersteinPromotion of sleep by targeting the orexin system in rats, dogs and humansNat Med132007150155
  • B.A.KummangalD.KumarH.N.MallickIntracerebroventricular injection of orexin-2 receptor antagonist promotes REM sleepBehav Brain Res23720135962
  • C.B.SaperT.C.ChouT.E.ScammellThe sleep switch: hypothalamic control of sleep and wakefulnessTrends Neurosci242001726731
  • K.YoshidaS.McCormackR.A.EspanaA.CrockerT.E.ScammellAfferents to the orexin neurons of the rat brainJ Comp Neurol4942006845861
  • K.K.WongS.Y.NgL.T.LeeH.K.NgB.K.ChowOrexins and their receptors from fish to mammals: a comparative approachGen Comp Endocrinol1712011124130
  • J.P.KukkonenT.HolmqvistS.AmmounK.E.AkermanFunctions of the orexinergic/hypocretinergic systemAm J Physiol Cell Physiol2832002C15671591
  • B.BoutrelP.J.KennyS.E.SpecioRole for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behaviorProc Natl Acad Sci U S A10220051916819173
  • G.C.HarrisM.WimmerG.Aston-JonesA role for lateral hypothalamic orexin neurons in reward seekingNature4372005556559
  • W.WangY.PanQ.LiWang L.OrexA potential role in the process of obstructive sleep apneaPeptides2013
  • K.IigayaJ.HoriuchiL.M.McDowallBlockade of orexin receptors with Almorexant reduces cardiorespiratory responses evoked from the hypothalamus but not baro- or chemoreceptor reflex responsesAm J Physiol Regul Integr Comp Physiol3032012R10111022
  • W.WangQ.LiY.PanD.ZhuL.WangInfluence of hypercapnia on the synthesis of neuropeptides and their receptors in murine brainRespirology182013102107
  • S.L.BorglandM.A.UnglessA.BonciConvergent actions of orexin/hypocretin and CRF on dopamine neurons: emerging players in addictionBrain Res13142010139144
  • A.J.LawrenceM.S.CowenH.J.YangF.ChenB.OldfieldThe orexin system regulates alcohol-seeking in ratsBr J Pharmacol1482006752759
  • M.NaritaY.NagumoS.HashimotoDirect involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphineJ Neurosci262006398405
  • J.A.HollanderQ.LuM.D.CameronT.M.KameneckaP.J.KennyInsular hypocretin transmission regulates nicotine rewardProc Natl Acad Sci U S A10520081948019485
  • J.K.RichardsJ.A.SimmsP.SteenslandInhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long-Evans ratsPsychopharmacology1992008109117
  • G.Aston-JonesR.J.SmithD.E.MoormanK.A.RichardsonRole of lateral hypothalamic orexin neurons in reward processing and addictionNeuropharmacology56Suppl. 12009112121
  • B.JuppB.KrivdicE.KrstewA.J.LawrenceThe orexin receptor antagonist SB-334867 dissociates the motivational properties of alcohol and sucrose in ratsBrain Res139120115459
  • N.CannellaM.KallupiB.RuggeriR.CiccocioppoM.UbaldiThe role of the neuropeptide S system in addiction: focus on its interaction with the CRF and hypocretin/orexin neurotransmissionProg Neurobiol10020134859
  • J.W.YeohM.H.JamesP.JoblingJ.S.BainsB.A.GrahamC.V.DayasCocaine potentiates excitatory drive in the perifornical/lateral hypothalamusJ Physiol590201236773689
  • Y.RaoY.S.MineurG.GanRepeated in vivo exposure of cocaine induces long-lasting synaptic plasticity in hypocretin/orexin neurons in the lateral hypothalamus in miceJ Physiol2013
  • H.A.ErkenG.ErkenO.GencOrexins cause epileptic activityPeptides372012161164
  • J.R.BarsonO.KaratayevV.GaysinskayaG.Q.ChangS.F.LeibowitzEffect of dietary fatty acid composition on food intake, triglycerides, and hypothalamic peptidesRegul Pept17320121320
  • A.WallH.VolkoffEffects of fasting and feeding on the brain mRNA expressions of orexin, tyrosine hydroxylase (TH), PYY and CCK in the Mexican blind cavefish (Astyanax fasciatus mexicanus)Gen Comp Endocrinol183C20134452
  • S.HaradaY.YamazakiS.TokuyamaOrexin-A suppresses postischemic glucose intolerance and neuronal damage through hypothalamic brain-derived neurotrophic factorJ Pharmacol Exper Ther3442013276285
  • E.YilmazO.CelikN.CelikMaternal and fetal serum orexin-A levels in gestational diabetes mellitusJ Obst Gynaecol Res392013139145
  • M.LopezM.Tena-SempereC.DieguezCross-talk between orexins (hypocretins) and the neuroendocrine axes (hypothalamic-pituitary axes)Front Neuroendocrinol312010113127
  • C.J.MaddenD.TuponeS.F.MorrisonOrexin modulates brown adipose tissue thermogenesisBiomol Concepts32012381386
  • C.E.Perez-LeightonK.BolandJ.A.TeskeC.BillingtonC.M.KotzBehavioral responses to orexin, orexin receptor gene expression, and spontaneous physical activity contribute to individual sensitivity to obesityAm J Physiol Endocrinol Metab3032012E865E874
  • M.SkrzypskiP.KaczmarekT.T.LeEffects of orexin A on proliferation, survival, apoptosis and differentiation of 3T3-L1 preadipocytes into mature adipocytesFEBS Lett586201241574164
  • C.PeyronD.K.TigheA.N.van den PolNeurons containing hypocretin (orexin) project to multiple neuronal systemsJ Neurosci181998999610015
  • X.Y.ZhangL.YuQ.X.ZhuangJ.N.ZhuJ.J.WangCentral functions of the orexinergic systemNeurosci Bull2013
  • A.Jawiarczyk-PrzybylowskaM.BolanowskiThe role of orexin A in metabolic disturbances in patients with acromegalyEndokrynol Pol632012463469
  • F.XiaoM.JiangD.DuOrexin A regulates cardiovascular responses in stress-induced hypertensive ratsNeuropharmacology6720131624
  • G.M.StettnerL.KubinAntagonism of orexin receptors in the posterior hypothalamus reduces hypoglossal and cardiorespiratory excitation from the perifornical hypothalamusJ Appl Physiol1142013119130
  • M.F.WuR.NienhuisN.MaidmentH.A.LamJ.M.SiegelCerebrospinal fluid hypocretin (orexin) levels are elevated by play but are not raised by exercise and its associated heart rate, blood pressure, respiration or body temperature changesArch Ital Biol1492011492498
  • X.XiongR.E.WhiteL.XuMitigation of murine focal cerebral ischemia by the hypocretin/orexin system is associated with reduced inflammationStroke J Cereb Circ2013
  • J.IqbalS.PompoloT.SakuraiI.J.ClarkeEvidence that orexin-containing neurones provide direct input to gonadotropin-releasing hormone neurones in the ovine hypothalamusJ Neuroendocrinol13200110331041
  • L.MartynskaJ.PolkowskaE.Wolinska-WitortOrexin A and its role in the regulation of the hypothalamo-pituitary axes in the ratReprod Biol6Suppl 220062935
  • S.PuM.R.JainP.S.KalraS.P.KalraOrexins, a novel family of hypothalamic neuropeptides, modulate pituitary luteinizing hormone secretion in an ovarian steroid-dependent mannerRegul Pept781998133136
  • R.SassonR.K.DearthR.S.WhiteP.E.ChappellP.L.MellonOrexin A induces GnRH gene expression and secretion from GT1-7 hypothalamic GnRH neuronsNeuroendocrinology842006353363
  • S.TafuriL.M.PavoneR.Lo MutoExpression of orexin A and its receptor 1 in the rat epididymisRegul Pept155200915
  • S.ZhangD.BlacheP.E.VercoeExpression of orexin receptors in the brain and peripheral tissues of the male sheepRegul Pept12420058187
  • M.L.BarreiroR.PinedaV.M.NavarroOrexin 1 receptor messenger ribonucleic acid expression and stimulation of testosterone secretion by orexin-A in rat testisEndocrinology145200422972306
  • A.VerrottiA.Di FonzoS.AgostinelliG.CoppolaM.MargiottaP.ParisiObese children suffer more often from migraineActa Paediatr1012012e416421
  • J.M.SiegelHypocretin (orexin): role in normal behavior and neuropathologyAnnu Rev Psychol552004125148
  • A.AdamantidisL.de LeceaThe hypocretins as sensors for metabolism and arousalJ Physiol58720093340
  • L.ChenJ.T.McKennaY.BolortuyaR.E.BrownR.W.McCarleyKnockdown of orexin type 2 receptor in the lateral pontomesencephalic tegmentum of rats increases REM sleepEur J Neurosci2013
  • J.Santamaria-CanoDiagnostic and therapeutic update in narcolepsyRev Neurol54Suppl 32012S2530
  • S.OvereemT.E.ScammellG.J.LammersHypocretin/orexin and sleep: implications for the pathophysiology and diagnosis of narcolepsyCurr Opin Neurol152002739745
  • M.NolletP.GaillardA.TantiV.GiraultC.BelzungS.LemanNeurogenesis-independent antidepressant-like effects on behavior and stress axis response of a dual orexin receptor antagonist in a rodent model of depressionNeuropsychopharmacology37201222102221
  • A.J.RoeckerP.J.ColemanOrexin receptor antagonists: medicinal chemistry and therapeutic potentialCurr Top Med Chem82008977987
  • J.PutulaP.M.TurunenM.H.JanttiM.E.EkholmJ.P.KukkonenAgonist ligand discrimination by the two orexin receptors depends on the expression systemNeurosci Lett49420115760
  • J.PutulaJ.P.KukkonenMapping of the binding sites for the OX1 orexin receptor antagonist, SB-334867, using orexin/hypocretin receptor chimaerasNeurosci Lett5062012111115
  • M.A.AkanmuK.HondaSelective stimulation of orexin receptor type 2 promotes wakefulness in freely behaving ratsBrain Res10482005138145
  • M.G.LeeO.K.HassaniB.E.JonesDischarge of identified orexin/hypocretin neurons across the sleep-waking cycleJ Neurosci25200567166720
  • I.V.EstabrookeM.T.McCarthyE.KoFos expression in orexin neurons varies with behavioral stateJ Neurosci21200116561662
  • J.A.ChristopherM.S.CongreveTreatment and prevention of various therapeutic conditions using OX receptor antagonistic activity (WO2012081692)Expert Opin Ther Pat232013273277
  • T.FujimotoY.TomataJ.KunitomoM.HirozaneS.MaruiDiscovery of spiropiperidine-based potent and selective Orexin-2 receptor antagonistsBioorg Med Chem Lett21201164096413
  • C.DugovicJ.E.SheltonL.E.AluisioBlockade of orexin-1 receptors attenuates orexin-2 receptor antagonism-induced sleep promotion in the ratJ Pharmacol Exp Ther3302009142151
  • Y.DauvilliersC.MorinK.CervenaFamily studies in insomniaJ Psychosom Res582005271278
  • R.M.BencaDiagnosis and treatment of chronic insomnia: a reviewPsychiatr Serv562005332343
  • D.J.FoleyA.A.MonjanS.L.BrownE.M.SimonsickR.B.WallaceD.G.BlazerSleep complaints among elderly persons: an epidemiologic study of three communitiesSleep181995425432
  • N.S.KamelJ.K.GammackInsomnia in the elderly: cause, approach, and treatmentAm J Med1192006463469
  • K.ManabeT.MatsuiM.YamayaSleep patterns and mortality among elderly patients in a geriatric hospitalGerontology462000318322
  • T.RothNew developments for treating sleep disordersJ Clin Psychiatry62Suppl. 10200134
  • L.StanerComorbidity of insomnia and depressionSleep Med Rev1420103546
  • A.CamineroM.BartolomeSleep disturbances in multiple sclerosisJ Neurol Sci30920118691
  • S.SullivanUpdate on emerging drugs for insomniaExpert Opin Emerg Drugs172012295298
  • R.Y.MooreE.A.AbrahamsonA.Van Den PolThe hypocretin neuron system: an arousal system in the human brainArch Ital Biol1392001195205
  • T.NambuT.SakuraiK.MizukamiY.HosoyaM.YanagisawaK.GotoDistribution of orexin neurons in the adult rat brainBrain Res8271999243260
  • J.P.NixonL.SmaleA comparative analysis of the distribution of immunoreactive orexin A and B in the brains of nocturnal and diurnal rodentsBehav Brain Funct3200728
  • Y.DateY.UetaH.YamashitaOrexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systemsProc Natl Acad Sci U S A961999748753
  • D.J.CutlerR.MorrisV.SheridharDifferential distribution of orexin-A and orexin-B immunoreactivity in the rat brain and spinal cordPeptides20199914551470
  • Y.DateM.S.MondalS.MatsukuraDistribution of orexin/hypocretin in the rat median eminence and pituitaryBrain Res Mol Brain Res76200016
  • M.ShibataM.S.MondalY.DateM.NakazatoH.SuzukiY.UetaDistribution of orexins-containing fibers and contents of orexins in the rat olfactory bulbNeurosci Res61200899105
  • M.J.WanatF.W.HopfG.D.StuberP.E.PhillipsA.BonciCorticotropin-releasing factor increases mouse ventral tegmental area dopamine neuron firing through a protein kinase C-dependent enhancement of IhJ Physiol586200821572170
  • R.E.BrownO.SergeevaK.S.ErikssonH.L.HaasOrexin A excites serotonergic neurons in the dorsal raphe nucleus of the ratNeuropharmacology402001457459
  • K.TakahashiY.KoyamaY.KayamaM.YamamotoEffects of orexin on the laterodorsal tegmental neuronesPsychiatry Clin Neurosci562002335336
  • T.M.KorotkovaO.A.SergeevaK.S.ErikssonH.L.HaasR.E.BrownExcitation of ventral tegmental area dopaminergic and nondopaminergic neurons by orexins/hypocretinsJ Neurosci232003711
  • M.A.UnglessV.SinghT.L.CrowderR.YakaD.RonA.BonciCorticotropin-releasing factor requires CRF binding protein to potentiate NMDA receptors via CRF receptor 2 in dopamine neuronsNeuron392003401407
  • S.L.BorglandS.A.TahaF.SartiH.L.FieldsA.BonciOrexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaineNeuron492006589601
  • T.M.KorotkovaR.E.BrownO.A.SergeevaA.A.PonomarenkoH.L.HaasEffects of arousal- and feeding-related neuropeptides on dopaminergic and GABAergic neurons in the ventral tegmental area of the ratEur J Neurosci23200626772685
  • J.W.MuschampJ.M.DominguezS.M.SatoR.Y.ShenE.M.HullA role for hypocretin (orexin) in male sexual behaviorJ Neurosci27200728372845
  • B.WangY.ShahamD.ZitzmanS.AzariR.A.WiseZ.B.YouCocaine experience establishes control of midbrain glutamate and dopamine by corticotropin-releasing factor: a role in stress-induced relapse to drug seekingJ Neurosci25200553895396
  • B.WangZ.B.YouR.A.WiseReinstatement of cocaine seeking by hypocretin (orexin) in the ventral tegmental area: independence from the local corticotropin-releasing factor networkBiol Psychiatry652009857862
  • P.J.ColemanJ.J.RengerOrexin receptor antagonists: a review of promising compounds patented since 2006Expert Opin Ther Pat202010307324
  • D.SmartC.Sabido-DavidS.J.BroughSB-334867-A: the first selective orexin-1 receptor antagonistBr J Pharmacol132200111791182
  • J.ChalmeauC.le GrimellecJ.SternickC.VieuPatterned domains of supported phospholipid bilayer using microcontact printing of Pll-g-PEG moleculesColloids Surf B892012188195
  • C.J.WinrowA.L.GotterC.D.CoxPromotion of sleep by suvorexant-a novel dual orexin receptor antagonistJ Neurogenet2520115261
  • H.SunW.P.KennedyD.WilbrahamEffects of suvorexant, an orexin receptor antagonist, on sleep parameters as measured by polysomnography in healthy menSleep362013259267
  • C.D.CoxM.J.BreslinD.B.WhitmanDiscovery of the dual orexin receptor antagonist [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H–1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the treatment of insomniaJ Med Chem53201053205332
  • B.D.BrielmaierEszopiclone (Lunesta): a new nonbenzodiazepine hypnotic agentProc (Bayl Univ Med Cent)1920065459
  • M.DaviesJ.G.NewellJ.M.DerryI.L.MartinS.M.DunnCharacterization of the interaction of zopiclone with gamma-aminobutyric acid type A receptorsMol Pharmacol582000756762
  • W.V.McCallM.ErmanA.D.KrystalA polysomnography study of eszopiclone in elderly patients with insomniaCurr Med Res Opin22200616331642
  • T.RothJ.K.WalshA.KrystalT.WesselT.A.RoehrsAn evaluation of the efficacy and safety of eszopiclone over 12 months in patients with chronic primary insomniaSleep Med62005487495
  • M.ScharfM.ErmanR.RosenbergA 2-week efficacy and safety study of eszopiclone in elderly patients with primary insomniaSleep282005720727
  • C.N.SoaresH.JoffeR.RubensJ.CaronT.RothL.CohenEszopiclone in patients with insomnia during perimenopause and early postmenopause: a randomized controlled trialObstet Gynecol108200614021410
  • J.K.WalshA.D.KrystalD.A.AmatoNightly treatment of primary insomnia with eszopiclone for six months: effect on sleep, quality of life, and work limitationsSleep302007959968
  • N.L.HarrisonMechanisms of sleep induction by GABA(A) receptor agonistsJ Clin Psychiatry68Suppl 52007612
  • T.RothA physiologic basis for the evolution of pharmacotherapy for insomniaJ Clin Psychiatry68Suppl 520071318
  • F.MicheliM.AntoliniR.Di FabioA.PellacaniA.Pozzan2-Methyl-3-furanyl-4H-1,2,4-triazol-3-ylthioamides: a new class of selective orexin 2 antagonistsBioorg Med Chem Lett20201064056407
  • K.OhnoT.SakuraiOrexin neuronal circuitry: role in the regulation of sleep and wakefulnessFront Neuroendocrinol2920087087
  • M.HochP.HoeverR.TheodorJ.DingemanseAlmorexant effects on CYP3A4 activity studied by its simultaneous and time-separated administration with simvastatin and atorvastatinEur J Clin Pharmacol2013
  • A.C.HaynesB.JacksonH.ChapmanA selective orexin-1 receptor antagonist reduces food consumption in male and female ratsRegul Pept9620004551
  • R.J.RodgersJ.C.HalfordR.L.Nunes de SouzaSB-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-A in rats.Eur J Neurosci13200114441452
  • S.AsahiS.EgashiraM.MatsudaDevelopment of an orexin-2 receptor selective agonist, [Ala(11), D-Leu(15)]orexin-BBioorg Med Chem Lett132003111113
  • T.FujimotoJ.KunitomoY.TomataDiscovery of potent, selective, orally active benzoxazepine-based Orexin-2 receptor antagonistsBioorg Med Chem Lett21201164146416
  • C.Blanco-CenturionM.LiuR.KonadhodeD.PelluruP.J.ShiromaniEffects of orexin gene transfer in the dorsolateral pons in orexin knockout miceSleep3620133140
  • L.A.DellN.PatzkeA.BhagwandinOrganization and number of orexinergic neurons in the hypothalamus of two species of Cetartiodactyla: a comparison of giraffe (Giraffa camelopardalis) and harbour porpoise (Phocoena phocoena)J Chem Neuroanat44201298109
  • W.J.HerringE.SnyderK.BuddOrexin receptor antagonism for treatment of insomnia: a randomized clinical trial of suvorexantNeurology79201222652274
  • J.PutulaP.M.TurunenL.JohanssonOrexin/hypocretin receptor chimaeras reveal structural features important for orexin peptide distinctionFEBS Lett585201113681374
  • C.L.WhiteY.IshiiT.MendozaEffect of a selective OX1R antagonist on food intake and body weight in two strains of rats that differ in susceptibility to dietary-induced obesityPeptides26200523312338
  • A.C.HaynesH.ChapmanC.TaylorAnorectic, thermogenic and anti-obesity activity of a selective orexin-1 receptor antagonist in ob/ob miceRegul Pept1042002153159
  • J.E.KangM.M.LimR.J.BatemanAmyloid-beta dynamics are regulated by orexin and the sleep-wake cycleScience326200910051007
  • P.L.JohnsonW.TruittS.D.FitzA key role for orexin in panic anxietyNat Med162010111115
  • L.de LeceaB.E.JonesB.BoutrelAddiction and arousal: alternative roles of hypothalamic peptidesJ Neurosci2620061037210375
  • M.TabaeizadehR.Motiei-LangroudiH.MirbahaThe differential effects of OX1R and OX2R selective antagonists on morphine conditioned place preference in naive versus morphine-dependent miceBehav Brain Res23720134148
  • A.RotterK.BayerleinM.HansbauerOrexin A expression and promoter methylation in patients with cannabis dependence in comparison to nicotine-dependent cigarette smokers and nonsmokersNeuropsychobiology662012126133
  • A.W.BruijnzeelTobacco addiction and the dysregulation of brain stress systemsNeurosci Biobehav Rev36201214181441
  • A.Plaza-ZabalaA.FloresR.MaldonadoF.BerrenderoHypocretin/orexin signaling in the hypothalamic paraventricular nucleus is essential for the expression of nicotine withdrawalBiol Psychiatry712012214223
  • R.J.RodgersF.L.WrightN.F.SnowL.J.TaylorOrexin-1 receptor antagonism fails to reduce anxiety-like behaviour in either plus-maze-naive or plus-maze-experienced miceBehav Brain Res2013
  • L.LionettoA.NegroS.PalmisaniEmerging treatment for chronic migraine and refractory chronic migraineExpert Opin Emerg Drugs172012393406
  • A.GhanemiBiological properties and perspective applications of “Bio-neuter” chemicals?Saudi Pharm J22201412
  • A.GhanemiToward overcoming the challenges facing biomedical analysesAlexandria J Med5132015277278
  • A.GhanemiIs mapping borders between pharmacology and toxicology a necessity?Saudi Pharm J2014
  • A.GhanemiCell cultures in drug development: Applications, challenges and limitationsSaudi Pharm J2014
  • A.GhanemiB.BoubertakhShorter and sturdier bridges between traditional Chinese medicines and modern pharmacologySaudi Pharm J2014
  • B.BoubertakhX.-G.LiuX.-L.ChengP.LiA spotlight on chemical constituents and pharmacological activities of Nigella glandulifera Freyn et Sint seedsJ Chem2013201312
  • A.GhanemiPsychiatric neural networks and neuropharmacology: Selected advances and novel implicationsSaudi Pharm J22201495100
  • A.GhanemiSchizophrenia and Parkinson’s disease: selected therapeutic advances beyond the dopaminergic etiologiesAlexandria J Med492013287291