Comparative evaluation between ascorbic acid and N-acetyl cysteine for preventing tourniquet induced ischaemic reperfusion injury during lower limb surgery, a randomized controlled trialFootnote

Peer review under responsibility of Egyptian Society of Anesthesiologists.

References

• M.MathruD.J.DriesL.BarnesP.ToninoR.SukhaniM.W.RooneyTourniquet–induced exsanguinations in patients requiring lower limb surgeryAnesthesiology8419961422
   PubMed Web of Science ®Google Scholar
• M.GirardisS.MilesiS.DonatoM.RaffaelliA.SpasianoG.AntonuttoThe hemodynamic and metabolic effects of tourniquet application during knee surgeryAnesth Analg912000727731
   PubMed Web of Science ®Google Scholar
• A.WakaiJ.H.WangD.C.WinterJ.T.StreetR.G.O’SullivanH.P.RedmondTourniquet–induced systemic inflammatory response in extremity surgeryJ Trauma512001922926
   PubMedGoogle Scholar
• M.J.ConcannonC.G.KesterC.F.WelshC.L.PuckettPatterns of free-radical production after tourniquet ischemia implications for the hand surgeonPlast Reconstr Surg891992846852
   PubMed Web of Science ®Google Scholar
• H.K.EltzschigC.D.CollardVascular ischaemia and reperfusion injuryBr Med Bull7020047186
   PubMed Web of Science ®Google Scholar
• R.W.BusuttilG.S.LipshutzJ.W.Kupiec-WeglinskiRPSGL-Ig for improvement of early liver allograft function: a double-blind, placebo-controlled, single-center phase II studyAm J Transplant112011786797
   PubMed Web of Science ®Google Scholar
• J.M.MccardThe evolution of free radicals and oxidative stressAm J Med1082000652659
   Web of Science ®Google Scholar
• R.M.RoumenT.HendriksJ.van der Ven-JongekrijgG.A.NieuwenhuijzenR.W.SauerweinJ.W.van der MeerCytokine patterns in patients after major vascular surgery, hemorrhagic shock, and severe blunt trauma: relation with subsequent adult respiratory distress syndrome and multiple organ failureAnn Surg2181993769776
   PubMed Web of Science ®Google Scholar
• V.AsensiE.ValleA.MeanaJ.FiererA.CeladaV.AlvarezIn vivo interleukin-6 protects neutrophils from apoptosis in osteomyelitisInfect Immun72200438233828
   Web of Science ®Google Scholar
• D.W.HarkinD.A.BarrosK.McCallionM.HoperM.I.HallidayF.C.CampbellBactericidal/permeability-increasing protein attenuates systemic inflammation and acute lung injury in porcine lower limb ischemia–reperfusion injuryAnn Surg2342001233244
   Web of Science ®Google Scholar
• B.SekhonC.SekhonM.KhanS.J.PatelI.SinghA.K.SinghN-Acetyl cysteine protects against injury in a rat model of focal cerebral ischemiaBrain Res971200318
   PubMed Web of Science ®Google Scholar
• Z.SunA.LassonK.OlandersX.DengR.AnderssonGut barrier permeability, reticuloendothelial system function and protease inhibitor levels following intestinal ischemia and reperfusion-effects of pre-treatment with N-acetyl-L-cysteine and indomethacineDigest Liver Dis342002560569
   Web of Science ®Google Scholar
• S.BasiliG.TanzilliE.MangieriIntravenous ascorbic acid infusion improves myocardial perfusion grade during elective percutaneous coronary intervention: relationship with oxidative stress markersJACC Cardiovasc Interv32010221229
   Web of Science ®Google Scholar
• T.YoshiokaK.KawadaT.ShimadaLipid peroxidation in maternal and cord blood and protective mechanism against activated-oxygen toxicity in the bloodAm J Obstet Gynecol13531979372376
   PubMed Web of Science ®Google Scholar
• H.AkarA.SaracC.KonuralpComparison of histopathologic effects of carnitine and ascorbic acid on reperfusion injuryEur J Cardiothorac Surg192001500506
   PubMed Web of Science ®Google Scholar
• S.Homer-VanniasinkamJ.N.CrinnionM.J.GoughPost-ischaemic organ dysfunction; a reviewEur J Vasc Endovasc Surg141997195203
   PubMed Web of Science ®Google Scholar
• Y.J.ChengY.P.WangC.T.ChienC.F.ChenSmall-dose propofol sedation attenuates the formation of reactive oxygen species in tourniquet–induced ischemia–reperfusion injury under spinal anesthesiaAnesth Analg94200216171620
   PubMed Web of Science ®Google Scholar
• M.VanC.OlgunerU.KocaA.R.SismanK.MuratliA.KarciO.MaviogluIschaemic preconditioning attenuates haemodynamic response and lipid peroxidation in lower extremity surgery with unilateral pneumatic tourniquet application: a clinical pilot studyAdv Ther252008355366
   PubMed Web of Science ®Google Scholar
• P.G.RaijmakersA.B.GroeneveldJ.A.RauwerdaG.J.TeuleC.E.HackAcute lung injury after aortic surgery: the relation between and leg microvascular permeability to 111 indium-labelled transferrin and circulating mediatorsThorax521997866871
   PubMed Web of Science ®Google Scholar
• I.BudićD.PavlovićT.CvetkovićN.DjordjevićD.SimićI.MilojevićThe effects of different anesthesia techniques on free radical production after tourniquet–induced ischemia–reperfusion injury at children’s ageVojnosanit Pregl6782010659664
   Web of Science ®Google Scholar
• L.N.LinL.R.WangW.T.WangL.L.JinX.Y.ZhaoL.P.ZhengIschemic preconditioning attenuates pulmonary dysfunction after unilateral thigh tourniquet–induced ischemia–reperfusionAnesth Analg1112010539543
   Web of Science ®Google Scholar
• F.SaricaogluD.DalA.E.SalmanM.N.DoralK.KilinçU.AyparKetamine sedation during spinal anesthesia for arthroscopic knee surgery reduced the ischemia–reperfusion injury markersAnesth Analg1012005904909
   PubMed Web of Science ®Google Scholar
• E.BostankoluH.AyogluS.YurtluR.D.OkyayG.ErdoganY.DenizDexmedetomidine did not reduce the effects of tourniquet–induced ischemia–reperfusion injury during general anesthesiaKaohsiung J Med Sci2920137581
   PubMed Web of Science ®Google Scholar
• O.AldemirH.CelebiC.CevikE.DuzgunThe effects of propofol or halothane on free radical production after tourniquet induced ischaemia–reperfusion injury during knee arthroplastyActa Anaesthesiol Scand45200112211225
   PubMed Web of Science ®Google Scholar
• G.SenerO.TosunA.O.SehirliMelatonin and N-acetyl cysteine have beneficial effects during hepatic ischemia and reperfusionLife Sci7224200327072718
   PubMed Web of Science ®Google Scholar
• H.NagasakiH.NakanoK.BoudjemaEfficacy of preconditioning with N-acetylcysteine against reperfusion injury after prolonged cold ischemia in rats liver in which glutathione had been reduced by buthionine sulphoximineEur J Surg16421998139146
   PubMedGoogle Scholar
• F.SaricaogluD.DalA.E.SalmanO.A.AtayM.N.DoralM.A.SalmanEffect of low-dose N-acetyl-cysteine infusion on tourniquet–induced ischaemia reperfusion injury in arthroscopic knee surgeryActa Anaesthesiol Scand492005847851
   PubMed Web of Science ®Google Scholar
• K.1.KocaY.YurttasT.CayciS.BilgicU.KaldirimThe role of preconditioning and N-acetylcysteine on oxidative stress resulting from tourniquet–induced ischemia–reperfusion in arthroscopic knee surgeryJ Trauma7032011717723
   PubMedGoogle Scholar
• S.J.PadayattyH.SunY.WangVitamin C pharmacokinetics: implications for oral and intravenous useAnn Intern Med1402004533537
   PubMed Web of Science ®Google Scholar
• A.K.NightingaleD.J.BlackmanR.FieldRole of nitric oxide and oxidative stress in baroreceptor dysfunction in patients with chronic heart failureClin Sci (Lond)1042003529535
   Web of Science ®Google Scholar
• H.DingchaoQ.ZhiduanH.LiyeThe protective effects of high-dose ascorbic acid on myocardium against reperfusion injury during and after cardiopulmonary bypassThorac Cardiovasc Surg421994276278
   Web of Science ®Google Scholar
• S.BasiliG.TanzilliE.MangieriV.RaparelliS.Di SantoP.PignatelliIntravenous ascorbic acid infusion improves myocardial perfusion grade during elective percutaneous coronary interventionJACC Cardiovasc Interv322010221229
   Web of Science ®Google Scholar
• Z.J.WangW.K.HuY.Y.LiuD.M.ShiW.J.ChengY.H.GuoThe effect of intravenous vitamin c infusion on periprocedural myocardial injury for patients undergoing elective percutaneous coronary interventionCan J Cardiol301201496101
   Web of Science ®Google Scholar
• J.Y.LeeC.J.KimM.Y.ChungEffect of high dose vitamin C on oxygen free radical production and myocardial enzyme after tourniquet ischaemia reperfusion injury during bilateral total knee replacementJ Int Med Res384201015191529
   PubMed Web of Science ®Google Scholar