Dichloro-substituted phenyl amino propanamides exhibit anticonvulsant effect and reduce inward sodium ion current (Na_V1.6)

References

• A.M.CookM.K.Bensalem-OwenMechanisms of action of antiepileptic drugsTherapy832011307313
   Google Scholar
• W.LasonM.ChlebickaK.RejdakResearch advances in basic mechanisms of seizures and antiepileptic drug actionPharmacol Rep652013787801
   PubMed Web of Science ®Google Scholar
• M.L.RuizR.KrawVoltage-gated sodium channels: structure, function, pharmacology and clinical indicationsJ Med Chem58201570937118
   PubMed Web of Science ®Google Scholar
• E.R.BenjaminF.FruthiS.OlanrewajuV.I.IlyinG.CrumleyE.Kutliniet al.State-dependent compound inhibition of NaV 1.2 sodium channels using the FLIPR Vm dye: on-target and off-target effects of diverse pharmacological agentsJ Biomol Screening11120062939
   Google Scholar
• G.M.LipkindH.A.FozzardMolecular model of anticonvulsant drug binding to the voltage-gated sodium channel inner poreMol Pharmacol7842010631638
   PubMed Web of Science ®Google Scholar
• N.J.HargusE.C.MerrickA.NigamC.L.KalmarA.R.BahetiE.H.Bertramet al.Temporal lobe epilepsy induces intrinsic alterations in Na channel gating in layer II medial entorhinal cortex neuronsNeurobiol Dis4122011361376
   Web of Science ®Google Scholar
• M.RiveraM.K.PatelV.ZulianiInhibition of NaV1.6 sodium channel currents by a novel series of 1,4-disubstituted-triazole derivatives obtained via copper-catalyzed click chemistryBioorg Med Chem22201264016404
   Web of Science ®Google Scholar
• R.GittoB.PaganoR.CitraroF.ScicchitanoG.DeSarroA.ChimirriSolution phase parallel synthesis and evaluation of anticonvulsant activity of N-substituted-3,4-dihydroisoquinoline-2(1H)-carboxamidesEur J Med Chem44200913491354
   Web of Science ®Google Scholar
• J.ObniskaA.RapaczS.RybkaM.GoraK.KaminskiK.Salatet al.Synthesis, and anticonvulsant activity of new amides derived from 3-methyl- or 3-ethyl-3 methyl-2,5-dioxo-pyrrolidin-1-yl-acetic acidsBioorg Med Chem24201615981607
   Google Scholar
• E.A.SwinyardH.J.KupferbergAntiepileptic drugs: detection, quantification and evaluationFed Proc.4419853943
   Google Scholar
• E.A.SwinyardLaboratory evaluation of antiepileptic drugs. Reviews of laboratory methodsEpilepsia101969107119
   PubMed Web of Science ®Google Scholar
• Y.K.GuptaM.ShirmaG.ChaudharyAntiepileptic activity of Panax Ginseng against pentylenetetrazole-induced kindling in ratsIndian J Pharmacol4542001502506
   Google Scholar
• A.DhirP.S.NaidaS.K.KulkarniNeuroprotective effect of nimesulide, a preferencial COX-2 inhibitor against pentylenetetrazole PTZ-induced chemical parameters in miceSeizure162007691697
   PubMed Web of Science ®Google Scholar
• A.RajabzadehA.E.BideskanA.FazelM.SankianH.RafatpanahH.HaghirThe effect of PTZ-induced epileptic seizures on hippocampal expression of PSA-NCAM in offspring born to kindled ratsJ Biomed Sci19120125664
   Google Scholar
• K.UnverferthJ.EngelN.HofgenA.RostockR.GuntherH.J.Lankauet al.Synthesis, anticonvulsant activity, and structure-activity relationships of sodium channel blocking 3-aminopyrrolesJ Med Chem4119986373
   PubMed Web of Science ®Google Scholar
• A.V.ShindikarF.KhanC.L.ViswanathanDesign, synthesis and in vivo anticonvulsant screening in mice of novel phenylacetamidesEur J Med Chem412006786792
   Web of Science ®Google Scholar
• E.N.BumG.N.NkantchouaN.NjikamG.S.TaiweG.T.NgoupayeM.M.PelankenAnticonvulsant and sedative activity of leaves Senna spectabilis in miceInt J Pharmacol62010123128
   Google Scholar
• S.Y.InanK.BuyukafsarAntiepileptic effects of two Rho-kinase inhibitors, Y-27632 and fusudil, in miceBr J Pharmacol15520084451
   PubMed Web of Science ®Google Scholar
• M.RazaF.ShaheenM.I.ChoudharyA.SuriaAttaur-RahmanS.Sombatiet al.Anticonvulsant activities of the FS-1 subfraction isolated from roots of Delphinium denudatumPhytother Res152001426430
   PubMed Web of Science ®Google Scholar
• P.NagakannanB.D.ShivasharanV.P.VeerapurB.S.ThppeswamySedative and antiepileptic effects of Anthocephalus cadamba Roxb. in mice and ratsIndian J Pharmacol4362011699702
   Web of Science ®Google Scholar
• B.MalawskaAnticonvulsant AgentsTop Med Chem520056985
   PubMed Web of Science ®Google Scholar
• A.DeSarroV.CecchettiP.FravolinF.NaccariO.TabarriniG.DeSarroEffects of novel 6-defluroquinolones and classic quinolones on Pentylenetetrazole-induced seizures in miceAntimicrob Agents Chemother43199917291736
   Web of Science ®Google Scholar
• J.M.RhoR.SankarThe pharmacological basis of antiepileptic drug actionEpilepsia40199914711483
   PubMed Web of Science ®Google Scholar
• Y.Hau-JieG.BaranauskasM.MartinaFlufenamic acid decreases neuronal excitability through modulation of voltage-gated sodium channel gatingJ Physiol58820201038693882
   Web of Science ®Google Scholar
• T.TakemiyaK.SuzukiH.SugiuraS.YasudaK.YamagataY.KawakamiInducible brain COX-2 facilitates the recurrence of hippocampal seizures in mouse rapid kindlingProstaglandin Lipid Mediator712003205216
   PubMed Web of Science ®Google Scholar
• M.A.RogawskiW.LoscherThe neurobiology of antiepileptic drugsNat Rev Neurosci52004553564
   PubMed Web of Science ®Google Scholar
• W.A.CatterallFrom ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channelsNeuron2620001325
   PubMed Web of Science ®Google Scholar
• W.A.CatterallVoltage-gated sodium channels at 60: structure, function and pathophysiologyJ Physiol59011201225772589
   PubMed Web of Science ®Google Scholar