3,388
Views
56
CrossRef citations to date
0
Altmetric
Review Article

Cancer preventive and therapeutic effects of EGCG, the major polyphenol in green tea

, , , &
Pages 1-23 | Received 14 Nov 2017, Accepted 06 Dec 2017, Published online: 06 Mar 2019

References

  • B.A.KohlerR.L.ShermanN.HowladerA.JemalA.B.RyersonK.A.Henryet al.Annual report to the nation on the status of cancer, 1975–2011, featuring incidence of breast cancer subtypes by race/ethnicity, poverty, and stateJ Natl Cancer Inst1072015djv048
  • I.RadyI.A.SiddiquiM.RadyH.MukhtarMelittin, a major peptide component of bee venom, and its conjugates in cancer therapyCancer Lett40220171631
  • H.Frankish15 million new cancer cases per year by 2020, says WHOLancet36120031278
  • J.ZugazagoitiaC.GuedesS.PonceI.FerrerS.Molina-PineloL.Paz-AresCurrent challenges in cancer treatmentClin Ther38201615511566
  • L.A.TorreF.BrayR.L.SiegelJ.FerlayJ.Lortet-TieulentA.JemalGlobal cancer statisticsCA Cancer J Clin652015201287108
  • J.FerlayI.SoerjomataramR.DikshitS.EserC.MathersM.Rebeloet al.Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012Int J Cancer1362015E359386
  • R.L.SiegelK.D.MillerA.JemalCancer statisticsCA Cancer J Clin6620162016730
  • S.Z.MoghadamtousiM.FadaeinasabS.NikzadG.MohanH.M.AliH.A.KadirAnnona muricata (Annonaceae): a review of its traditional uses, isolated acetogenins and biological activitiesInt J Mol Sci1620151562515658
  • B.PeterS.BoszeR.HorvathBiophysical characteristics of proteins and living cells exposed to the green tea polyphenol epigallocatechin-3-gallate (EGCg): review of recent advances from molecular mechanisms to nanomedicine and clinical trialsEur Biophys J462017124
  • U.P.de AlbuquerqueG.T.SoldatiS.S.SieberM.A.RamosJ.C.de SaL.C.de SouzaThe use of plants in the medical system of the Fulni-o people (NE Brazil): a perspective on age and genderJ Ethnopharmacol1332011866873
  • E.E.CamargoM.A.BandeiraA.G.de OliveiraDiagnosis of public programs focused on herbal medicines in BrazilNat Prod Commun6201110011002
  • G.KomlagaC.AgyareR.A.DicksonM.L.MensahK.AnnanP.M.Loiseauet al.Medicinal plants and finished marketed herbal products used in the treatment of malaria in the Ashanti region, GhanaJ Ethnopharmacol1722015333346
  • I.A.SiddiquiV.M.AdhamiN.AhmadH.MukhtarNanochemoprevention: sustained release of bioactive food components for cancer preventionNutr Cancer622010883890
  • S.M.ChackoP.T.ThambiR.KuttanI.NishigakiBeneficial effects of green tea: a literature reviewChin Med5201013
  • J.A.VinsonBlack and green tea and heart disease: a reviewBiofactors132000127132
  • C.SnoussiR.DucrocM.H.HamdaouiK.DhaouadiH.AbaidiF.Cluzeaudet al.Green tea decoction improves glucose tolerance and reduces weight gain of rats fed normal and high-fat dietJ Nutr Biochem252014557564
  • M.SanoM.TabataM.SuzukiM.DegawaT.MiyaseM.Maeda-YamamotoSimultaneous determination of twelve tea catechins by high-performance liquid chromatography with electrochemical detectionAnalyst1262001816820
  • J.SteinmannJ.BuerT.PietschmannE.SteinmannAnti-infective properties of epigallocatechin-3-gallate (EGCG), a component of green teaBr J Pharmacol168201310591073
  • C.S.YangH.WangCancer therapy combination: green tea and a phosphodiesterase 5 inhibitor?J Clin Invest1232013556558
  • H.H.BaileyH.MukhtarGreen tea polyphenols and cancer chemoprevention of genitourinary cancerAm Soc Clin Oncol Educ Book20139296
  • N.KhanH.MukhtarCancer and metastasis: prevention and treatment by green teaCancer Metastasis Rev292010435445
  • I.A.SiddiquiV.SannaImpact of nanotechnology on the delivery of natural products for cancer prevention and therapyMol Nutr Food Res60201613301341
  • M.SaleemV.M.AdhamiI.A.SiddiquiH.MukhtarTea beverage in chemoprevention of prostate cancer: a mini-reviewNutr Cancer4720031323
  • D.G.NagleD.FerreiraY.D.ZhouEpigallocatechin-3-gallate (EGCG): chemical and biomedical perspectivesPhytochemistry67200618491855
  • V.M.AdhamiN.AhmadH.MukhtarMolecular targets for green tea in prostate cancer preventionJ Nutr13320032417S2424S
  • I.A.SiddiquiV.M.AdhamiD.J.BharaliB.B.HafeezM.AsimS.I.Khwajaet al.Introducing nanochemoprevention as a novel approach for cancer control: proof of principle with green tea polyphenol epigallocatechin-3-gallateCancer Res69200917121716
  • H.WagnerG.Ulrich-MerzenichSynergy research: approaching a new generation of phytopharmaceuticalsPhytomedicine16200997110
  • S.N.SaldanhaT.O.TollefsbolThe role of nutraceuticals in chemoprevention and chemotherapy and their clinical outcomesJ Oncol20122012192464
  • R.Y.GanH.B.LiZ.Q.SuiH.CorkeAbsorption, metabolism, anti-cancer effect and molecular targets of epigallocatechin gallate (EGCG): An updated reviewCrit Rev Food Sci Nutr2016118
  • A.A.RahmanS.MakpolR.JamalR.HarunN.MokhtarW.Z.NgahTocotrienol-rich fraction, [6]-gingerol and epigallocatechin gallate inhibit proliferation and induce apoptosis of glioma cancer cellsMolecules1920141452814541
  • T.J.Somers-EdgarM.J.ScandlynE.C.StuartM.J.Le NedelecS.P.ValentineR.J.RosengrenThe combination of epigallocatechin gallate and curcumin suppresses ER alpha-breast cancer cell growth in vitro and in vivoInt J Cancer122200819661971
  • F.YeG.H.ZhangB.X.GuanX.C.XuSuppression of esophageal cancer cell growth using curcumin, (-)-epigallocatechin-3-gallate and lovastatinWorld J Gastroenterol182012126135
  • P.WangD.HeberS.M.HenningQuercetin increased the antiproliferative activity of green tea polyphenol (-)-epigallocatechin gallate in prostate cancer cellsNutr Cancer642012580587
  • S.NairA.BarveT.O.KhorG.X.ShenW.LinJ.Y.Chanet al.Regulation of Nrf2- and AP-1-mediated gene expression by epigallocatechin-3-gallate and sulforaphane in prostate of Nrf2-knockout or C57BL/6J mice and PC-3 AP-1 human prostate cancer cellsActa Pharmacol Sin31201012231240
  • G.J.DuC.Z.WangL.W.QiZ.Y.ZhangT.CalwayT.C.Heet al.The synergistic apoptotic interaction of panaxadiol and epigallocatechin gallate in human colorectal cancer cellsPhytother Res272013272277
  • S.F.KostinD.E.McDonaldD.W.McFaddenInhibitory effects of (-)-epigallocatechin-3-gallate and pterostilbene on pancreatic cancer growth in vitroJ Surg Res1772012255262
  • S.TodenH.M.TranO.A.Tovar-CamargoY.OkugawaA.GoelEpigallocatechin-3-gallate targets cancer stem-like cells and enhances 5-fluorouracil chemosensitivity in colorectal cancerOncotarget720161615816171
  • H.WuY.XinC.XuY.XiaoCapecitabine combined with (-)-epigallocatechin-3-gallate inhibits angiogenesis and tumor growth in nude mice with gastric cancer xenograftsExp Ther Med32012650654
  • S.H.LeeH.J.NamH.J.KangH.W.KwonY.C.LimEpigallocatechin-3-gallate attenuates head and neck cancer stem cell traits through suppression of Notch pathwayEur J Cancer49201332103218
  • H.WuY.XinY.XiaoJ.ZhaoLow-dose docetaxel combined with (-)-epigallocatechin-3-gallate inhibits angiogenesis and tumor growth in nude mice with gastric cancer xenograftsCancer Biother Radiopharm272012204209
  • M.E.StearnsM.D.AmatangeloD.VarmaC.SellS.M.GoodyearCombination therapy with epigallocatechin-3-gallate and doxorubicin in human prostate tumor modeling studies: inhibition of metastatic tumor growth in severe combined immunodeficiency miceAm J Pathol177201031693179
  • Y.ZhangS.X.WangJ.W.MaH.Y.LiJ.C.YeS.M.Xieet al.EGCG inhibits properties of glioma stem-like cells and synergizes with temozolomide through downregulation of P-glycoprotein inhibitionJ Neurooncol12120154152
  • S.N.SaldanhaR.KalaT.O.TollefsbolMolecular mechanisms for inhibition of colon cancer cells by combined epigenetic-modulating epigallocatechin gallate and sodium butyrateExp Cell Res32420144053
  • M.W.RoomiV.IvanovT.KalinovskyA.NiedzwieckiM.RathAnti-tumor effect of ascorbic acid, lysine, proline, arginine, and epigallocatechin gallate on prostate cancer cell lines PC-3, LNCaP, and DU145Res Commun Mol Pathol Pharmacol115–1162004251264
  • D.H.ZhouX.WangM.YangX.ShiW.HuangQ.FengCombination of low concentration of (-)-epigallocatechin gallate (EGCG) and curcumin strongly suppresses the growth of non-small cell lung cancer in vitro and in vivo through causing cell cycle arrestInt J Mol Sci1420131202312036
  • A.PapiF.FarabegoliR.IoriM.OrlandiG.R.De NicolaM.Bagattaet al.Vitexin-2-O-xyloside, raphasatin and (-)-epigallocatechin-3-gallate synergistically affect cell growth and apoptosis of colon cancer cellsFood Chem138201315211530
  • R.M.HagenV.S.ChedeaC.P.MintoffE.BowlerH.R.MorseM.R.LadomeryEpigallocatechin-3-gallate promotes apoptosis and expression of the caspase 9a splice variant in PC3 prostate cancer cellsInt J Oncol432013194200
  • S.ShankarG.SuthakarR.K.SrivastavaEpigallocatechin-3-gallate inhibits cell cycle and induces apoptosis in pancreatic cancerFront Biosci12200750395051
  • V.SannaC.K.SinghR.JashariV.M.AdhamiJ.C.ChamcheuI.Radyet al.Targeted nanoparticles encapsulating (-)-epigallocatechin-3-gallate for prostate cancer prevention and therapySci Rep7201741573
  • S.W.TaitD.R.GreenMitochondria and cell death: outer membrane permeabilization and beyondNat Rev Mol Cell Biol112010621632
  • J.F.KerrA.H.WyllieA.R.CurrieApoptosis: a basic biological phenomenon with wide-ranging implications in tissue kineticsBr J Cancer261972239257
  • R.C.TaylorS.P.CullenS.J.MartinApoptosis: controlled demolition at the cellular levelNat Rev Mol Cell Biol92008231241
  • M.L.XuJ.HuB.P.GuoY.R.NiuC.XiaoY.X.XuExploration of intrinsic and extrinsic apoptotic pathways in zearalenone-treated rat sertoli cellsEnviron Toxicol2015
  • A.ChalahR.Khosravi-FarThe mitochondrial death pathwayAdv Exp Med Biol61520082545
  • C.LanglaisM.A.HughesK.CainM.MacFarlaneIn vitro assembly and analysis of the apoptosome complexCold Spring Harb Protoc20152015 pdb.prot087080
  • M.BrentnallL.Rodriguez-MenocalR.L.De GuevaraE.CeperoL.H.BoiseCaspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosisBMC Cell Biol14201332
  • D.SiegmundD.MauriN.PetersP.JuoM.ThomeM.Reichweinet al.Fas-associated death domain protein (FADD) and caspase-8 mediate up-regulation of c-Fos by Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) via a FLICE inhibitory protein (FLIP)-regulated pathwayJ Biol Chem27620013258532590
  • E.KavanaghQuantification of active caspase-3 and active caspase-8 in microglia cellsMethods Mol Biol10412013113120
  • L.L.PanA.Y.WangY.Q.HuangY.LuoM.LingMangiferin induces apoptosis by regulating Bcl-2 and Bax expression in the CNE2 nasopharyngeal carcinoma cell lineAsian Pac J Cancer Prev15201470657068
  • W.XuL.JingQ.WangC.C.LinX.ChenJ.Diaoet al.Bax-PGAM5L-Drp1 complex is required for intrinsic apoptosis executionOncotarget620153001730034
  • K.T.ChangA.AnishkinG.A.PatwardhanL.J.BeverlyL.J.SiskindM.ColombiniCeramide channels: destabilization by Bcl-xL and role in apoptosisBiochim Biophys Acta2015184823742384
  • C.DeOcesano-PereiraM.S.AmaralK.S.ParreiraA.C.AyupeJ.F.JacysynG.P.Amarante-Mendeset al.Long non-coding RNA INXS is a critical mediator of BCL-XS induced apoptosisNucleic Acids Res42201483438355
  • S.Y.YuR.QiRole of bad in podocyte apoptosis induced by puromycin aminonucleosideTransplant Proc452013569573
  • S.MaC.HockingsK.AnwariT.KratinaS.FennellM.Lazarouet al.Assembly of the Bak apoptotic pore: a critical role for the Bak protein alpha6 helix in the multimerization of homodimers during apoptosisJ Biol Chem28820132602726038
  • C.GaoW.J.GuoA.Y.WangSignificance of decreased apoptosis, role of Bid expression and Bcl-Xl/Bid ratio in human jejunal stromal tumorsAPMIS1202012171181
  • N.MuthalaguM.R.JunttilaK.E.WieseE.WolfJ.MortonB.Baueret al.BIM is the primary mediator of MYC-induced apoptosis in multiple solid tissuesCell Rep8201413471353
  • C.ChenL.QincaoJ.XuS.DuE.HuangC.Liuet al.Role of PUMA in methamphetamine-induced neuronal apoptosisToxicol Lett2402016149160
  • S.MukhopadhyayP.K.PandaN.SinhaD.N.DasS.K.BhutiaAutophagy and apoptosis: where do they meet?Apoptosis192014555566
  • H.HeL.H.ZangY.S.FengL.X.ChenN.KangS.Tashiroet al.Physalin A induces apoptosis via p53-Noxa-mediated ROS generation, and autophagy plays a protective role against apoptosis through p38-NF-kappaB survival pathway in A375–S2 cellsJ Ethnopharmacol1482013544555
  • Y.ZhangY.HaoQ.SunC.PengRole of Smac in apoptosis of lung cancer cells A549 induced by TaxolClin Lab6120151721
  • E.R.HahmJ.LeeS.V.SinghRole of mitogen-activated protein kinases and Mcl-1 in apoptosis induction by withaferin A in human breast cancer cellsMol Carcinog532014907916
  • A.R.SafaC-FLIP, a master anti-apoptotic regulatorExp Oncol342012176184
  • Y.TangD.Y.ZhaoS.ElliottW.ZhaoT.J.CurielB.S.Beckmanet al.Epigallocatechin-3 gallate induces growth inhibition and apoptosis in human breast cancer cells through survivin suppressionInt J Oncol312007705711
  • A.BasuS.HaldarCombinatorial effect of epigallocatechin-3-gallate and TRAIL on pancreatic cancer cell deathInt J Oncol342009281286
  • R.L.ThangapazhamN.PassiR.K.MaheshwariGreen tea polyphenol and epigallocatechin gallate induce apoptosis and inhibit invasion in human breast cancer cellsCancer Biol Ther6200719381943
  • P.P.WuS.C.KuoW.W.HuangJ.S.YangK.C.LaiH.J.Chenet al.(-)-Epigallocatechin gallate induced apoptosis in human adrenal cancer NCI-H295 cells through caspase-dependent and caspase-independent pathwayAnticancer Res29200914351442
  • Q.HuX.ChangR.YanC.RongC.YangS.Chenget al.(-)-Epigallocatechin-3-gallate induces cancer cell apoptosis via acetylation of amyloid precursor proteinMed Oncol322015390
  • C.OnodaK.KuribayashiS.NirasawaN.TsujiM.TanakaD.Kobayashiet al.(-)-Epigallocatechin-3-gallate induces apoptosis in gastric cancer cell lines by down-regulating survivin expressionInt J Oncol38201114031408
  • K.R.Landis-PiwowarC.D.HuoD.ChenV.MilacicG.Q.ShiT.H.Chanet al.A novel prodrug of the green tea polyphenol (-)-epigallocatechin-3-gallate as a potential anticancer agentCancer Research67200743034310
  • M.A.FeitelsonA.ArzumanyanR.J.KulathinalS.W.BlainR.F.HolcombeJ.Mahajnaet al.Sustained proliferation in cancer: Mechanisms and novel therapeutic targetsSemin Cancer Biol35Suppl2015S2554
  • S.LimP.KaldisCdks, cyclins and CKIs: roles beyond cell cycle regulationDevelopment140201330793093
  • A.SuzukiM.HayashidaT.ItoH.KawanoT.NakanoM.Miuraet al.Survivin initiates cell cycle entry by the competitive interaction with Cdk4/p16(INK4a) and Cdk2/cyclin E complex activationOncogene19200032253234
  • S.Di AgostinoS.StranoV.EmiliozziV.ZerbiniM.MottoleseA.Sacchiet al.Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulationCancer Cell102006191202
  • C.H.HuangS.J.TsaiY.J.WangM.H.PanJ.Y.KaoT.D.WayEGCG inhibits protein synthesis, lipogenesis, and cell cycle progression through activation of AMPK in p53 positive and negative human hepatoma cellsMol Nutr Food Res53200911561165
  • C.SharmaA.Nusri QelS.BegumE.JavedT.A.RizviA.Hussain(-)-Epigallocatechin-3-gallate induces apoptosis and inhibits invasion and migration of human cervical cancer cellsAsian Pac J Cancer Prev13201248154822
  • Y.C.MaC.LiF.GaoY.XuZ.B.JiangJ.X.Liuet al.Epigallocatechin gallate inhibits the growth of human lung cancer by directly targeting the EGFR signaling pathwayOncol Rep31201413431349
  • S.GuptaN.AhmadA.L.NieminenH.MukhtarGrowth inhibition, cell-cycle dysregulation, and induction of apoptosis by green tea constituent (-)-epigallocatechin-3-gallate in androgen-sensitive and androgen-insensitive human prostate carcinoma cellsToxicol Appl Pharmacol16420008290
  • Y.QiaoJ.CaoL.XieX.ShiCell growth inhibition and gene expression regulation by (-)-epigallocatechin-3-gallate in human cervical cancer cellsArch Pharm Res32200913091315
  • X.ZhangK.W.MinJ.WimalasenaS.J.BaekCyclin D1 degradation and p21 induction contribute to growth inhibition of colorectal cancer cells induced by epigallocatechin-3-gallateJ Cancer Res Clin Oncol138201220512060
  • N.AhmadV.M.AdhamiS.GuptaP.ChengH.MukhtarRole of the retinoblastoma (pRb)-E2F/DP pathway in cancer chemopreventive effects of green tea polyphenol epigallocatechin-3-gallateArch Biochem Biophys3982002125131
  • N.BhatiaC.AgarwalR.AgarwalDifferential responses of skin cancer-chemopreventive agents silibinin, quercetin, and epigallocatechin 3-gallate on mitogenic signaling and cell cycle regulators in human epidermoid carcinoma A431 cellsNutr Cancer392001292299
  • J.FolkmanAngiogenesisAnnu Rev Med572006118
  • P.CarmelietR.K.JainAngiogenesis in cancer and other diseasesNature4072000249257
  • A.BirbrairT.ZhangZ.M.WangM.L.MessiJ.D.OlsonA.Mintzet al.Type-2 pericytes participate in normal and tumoral angiogenesisAm J Physiol Cell Physiol3072014C2538
  • S.LiekensE.De ClercqJ.NeytsAngiogenesis: regulators and clinical applicationsBiochem Pharmacol612001253270
  • S.Y.ProskuryakovV.L.GabaiMechanisms of tumor cell necrosisCurr Pharm Des1620105668
  • G.BredholtM.MannelqvistI.M.StefanssonE.BirkelandT.H.BoA.M.Oyanet al.Tumor necrosis is an important hallmark of aggressive endometrial cancer and associates with hypoxia, angiogenesis and inflammation responsesOncotarget620153967639691
  • K.StielerU.SchumacherA.K.HorstN.FischerXMRV induces cell migration, cytokine expression and tumor angiogenesis: are 22Rv1 cells a suitable prostate cancer model?PLoS One72012e42321
  • T.MatsuokaM.YashiroRho/ROCK signaling in motility and metastasis of gastric cancerWorld J Gastroenterol2020141375613766
  • H.ZhouB.ZhangJ.ZhengM.YuT.ZhouK.Zhaoet al.The inhibition of migration and invasion of cancer cells by graphene via the impairment of mitochondrial respirationBiomaterials35201415971607
  • J.RelatA.BlancafortG.OliverasS.CufiD.HaroP.F.Marreroet al.Different fatty acid metabolism effects of (-)-epigallocatechin-3-gallate and C75 in adenocarcinoma lung cancerBMC Cancer122012280
  • Y.SakamotoN.TerashitaT.MuraguchiT.FukusatoS.KubotaEffects of epigallocatechin-3-gallate (EGCG) on A549 lung cancer tumor growth and angiogenesisBiosci Biotechnol Biochem77201317991803
  • X.LiY.FengJ.LiuX.FengK.ZhouX.TangEpigallocatechin-3-gallate inhibits IGF-I-stimulated lung cancer angiogenesis through downregulation of HIF-1alpha and VEGF expressionJ Nutrigenet Nutrigenomics62013169178
  • L.HeE.ZhangJ.ShiX.LiK.ZhouQ.Zhanget al.(-)-Epigallocatechin-3-gallate inhibits human papillomavirus (HPV)-16 oncoprotein-induced angiogenesis in non-small cell lung cancer cells by targeting HIF-1alphaCancer Chemother Pharmacol712013713725
  • J.ShiF.LiuW.ZhangX.LiuB.LinX.TangEpigallocatechin-3-gallate inhibits nicotine-induced migration and invasion by the suppression of angiogenesis and epithelial-mesenchymal transition in non-small cell lung cancer cellsOncol Rep33201529722980
  • A.TakahashiT.WatanabeA.MondalK.SuzukiM.Kurusu-KannoZ.Liet al.Mechanism-based inhibition of cancer metastasis with (-)-epigallocatechin gallateBiochem Biophys Res Commun443201416
  • Z.YinE.C.HenryT.A.Gasiewicz(-)-Epigallocatechin-3-gallate is a novel Hsp90 inhibitorBiochemistry482009336345
  • K.BelguiseS.GuoG.E.SonensheinActivation of FOXO3a by the green tea polyphenol epigallocatechin-3-gallate induces estrogen receptor alpha expression reversing invasive phenotype of breast cancer cellsCancer Res67200757635770
  • Y.ZhangG.HanB.FanY.ZhouX.ZhouL.Weiet al.Green tea (-)-epigallocatechin-3-gallate down-regulates VASP expression and inhibits breast cancer cell migration and invasion by attenuating Rac1 activityEur J Pharmacol6062009172179
  • T.SenA.ChatterjeeEpigallocatechin-3-gallate (EGCG) downregulates EGF-induced MMP-9 in breast cancer cells: involvement of integrin receptor alpha5beta1 in the processEur J Nutr502011465478
  • P.N.ChenS.C.ChuW.H.KuoM.Y.ChouJ.K.LinY.S.HsiehEpigallocatechin-3 gallate inhibits invasion, epithelial-mesenchymal transition, and tumor growth in oral cancer cellsJ Agric Food Chem59201138363844
  • Y.W.KohE.C.ChoiS.U.KangH.S.HwangM.H.LeeJ.Pyunet al.Green tea (-)-epigallocatechin-3-gallate inhibits HGF-induced progression in oral cavity cancer through suppression of HGF/c-MetJ Nutr Biochem22201110741083
  • Y.S.HwangK.K.ParkW.Y.ChungEpigallocatechin-3 gallate inhibits cancer invasion by repressing functional invadopodia formation in oral squamous cell carcinomaEur J Pharmacol7152013286295
  • B.H.ZhuH.Y.ChenW.H.ZhanC.Y.WangS.R.CaiZ.Wanget al.(-)-Epigallocatechin-3-gallate inhibits VEGF expression induced by IL-6 via Stat3 in gastric cancerWorld J Gastroenterol17201123152325
  • B.H.ZhuW.H.ZhanZ.R.LiZ.WangY.L.HeJ.S.Penget al.(-)-Epigallocatechin-3-gallate inhibits growth of gastric cancer by reducing VEGF production and angiogenesisWorld J Gastroenterol13200711621169
  • M.ShimizuY.ShirakamiH.SakaiY.YasudaM.KubotaS.Adachiet al.(-)-Epigallocatechin gallate inhibits growth and activation of the VEGF/VEGFR axis in human colorectal cancer cellsChem Biol Interact1852010247252
  • F.ZhouH.ZhouT.WangY.MuB.WuD.L.Guoet al.Epigallocatechin-3-gallate inhibits proliferation and migration of human colon cancer SW620 cells in vitroActa Pharmacol Sin332012120126
  • T.MaruyamaS.MurataK.NakayamaN.SanoK.OgawaT.Nowatariet al.(-)-Epigallocatechin-3-gallate suppresses liver metastasis of human colorectal cancerOncol Rep312014625633
  • C.A.LarsenR.H.Dashwood(-)-Epigallocatechin-3-gallate inhibits Met signaling, proliferation, and invasiveness in human colon cancer cellsArch Biochem Biophys50120105257
  • C.A.LarsenR.H.DashwoodSuppression of Met activation in human colon cancer cells treated with (-)-epigallocatechin-3-gallate: minor role of hydrogen peroxideBiochem Biophys Res Commun3892009527530
  • J.QinY.WangY.BaiK.YangQ.MaoY.Linet al.Epigallocatechin-3-gallate inhibits bladder cancer cell invasion via suppression of NF-kappaBmediated matrix metalloproteinase-9 expressionMol Med Rep6201210401044
  • D.DuhonR.L.BigelowD.T.ColemanJ.J.SteffanC.YuW.Langstonet al.The polyphenol epigallocatechin-3-gallate affects lipid rafts to block activation of the c-Met receptor in prostate cancer cellsMol Carcinog492010739749
  • S.C.LeeW.K.ChanT.W.LeeW.H.LamX.WangT.H.Chanet al.Effect of a prodrug of the green tea polyphenol (-)-epigallocatechin-3-gallate on the growth of androgen-independent prostate cancer in vivoNutr Cancer602008483491
  • M.A.MosesE.C.HenryW.A.RickeT.A.GasiewiczThe heat shock protein 90 inhibitor, (-)-epigallocatechin gallate, has anticancer activity in a novel human prostate cancer progression modelCancer Prev Res (Phila)82015249257
  • S.WangR.ChenZ.ZhongZ.ShiM.ChenY.WangEpigallocatechin-3-gallate potentiates the effect of curcumin in inducing growth inhibition and apoptosis of resistant breast cancer cellsAm J Chin Med42201412791300
  • J.D.LambertS.SangC.S.YangN-Acetylcysteine enhances the lung cancer inhibitory effect of epigallocatechin-3-gallate and forms a new adductFree Radic Biol Med44200810691074
  • S.GuptaK.HastakN.AhmadJ.S.LewinH.MukhtarInhibition of prostate carcinogenesis in TRAMP mice by oral infusion of green tea polyphenolsProc Natl Acad Sci U S A9820011035010355
  • L.D'AngeloG.PiazziA.PacilliA.ProssomaritiC.FazioL.Montanaroet al.A combination of eicosapentaenoic acid-free fatty acid, epigallocatechin-3-gallate and proanthocyanidins has a strong effect on mTOR signaling in colorectal cancer cellsCarcinogenesis35201423142320
  • A.KaleS.GawandeS.KotwalS.NetkeW.RoomiV.Ivanovet al.Studies on the effects of oral administration of nutrient mixture, quercetin and red onions on the bioavailability of epigallocatechin gallate from green tea extractPhytother Res24Suppl 12010S4855
  • S.DawoodL.AustinM.CristofanilliCancer stem cells: implications for cancer therapyOncology28201411011107 [1110]
  • J.A.AjaniS.SongH.S.HochsterI.B.SteinbergCancer stem cells: the promise and the potentialSemin Oncol42Suppl 12015S317
  • S.N.TangC.SinghD.NallD.MeekerS.ShankarR.K.SrivastavaThe dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transitionJ Mol Signal5201014
  • N.D.MinevaK.E.PaulsonS.P.NaberA.S.YeeG.E.SonensheinEpigallocatechin-3-gallate inhibits stem-like inflammatory breast cancer cellsPLoS One82013e73464
  • N.NishimuraT.B.HartomoT.V.PhamM.J.LeeT.YamamotoS.Morikawaet al.Y.TakeshimaK.IijimaM.MatsuoH.NishioEpigallocatechin gallate inhibits sphere formation of neuroblastoma BE(2)-C cellsEnviron Health Prev Med172012246251
  • D.W.EomJ.H.LeeY.J.KimG.S.HwangS.N.KimJ.H.Kwaket al.Synergistic effect of curcumin on epigallocatechin gallate-induced anticancer action in PC3 prostate cancer cellsBMB Rep482015461466
  • D.Z.WeiJ.Y.YangJ.W.LiuW.Y.TongInhibition of liver cancer cell proliferation and migration by a combination of (-)-epigallocatechin-3-gallate and ascorbic acidJ Chemother152003591595
  • M.W.RoomiV.IvanovT.KalinovskyA.NiedzwieckiM.RathAntitumor effect of ascorbic acid, lysine, proline, arginine, and green tea extract on bladder cancer cell line T-24Int J Urol132006415419
  • Y.J.LiS.L.WuS.M.LuF.ChenY.GuoS.M.Ganet al.(-)-Epigallocatechin-3-gallate inhibits nasopharyngeal cancer stem cell self-renewal and migration and reverses the epithelial-mesenchymal transition via NF-kappaB p65 inactivationTumour Biol36201527472761
  • I.A.SiddiquiH.MukhtarNanochemoprevention by bioactive food components: a perspectivePharm Res27201010541060
  • I.A.SiddiquiV.M.AdhamiJ.C.ChamcheuH.MukhtarImpact of nanotechnology in cancer: emphasis on nanochemopreventionInt J Nanomedicine72012591605
  • S.NarayananU.MonyD.K.VijaykumarM.KoyakuttyB.Paul-PrasanthD.MenonSequential release of epigallocatechin gallate and paclitaxel from PLGA-casein core/shell nanoparticles sensitizes drug-resistant breast cancer cellsNanomedicine11201513991406
  • S.S.ShafieiM.Solati-HashjinA.SamadikuchaksaraeiR.KalantarinejadM.Asadi-EydivandN.A.Abu Osmanpigallocatechin gallate/layered double hydroxide nanohybrids: preparation, characterization, and in vitro anti-tumor studyPLoS One102015e0136530
  • N.KhanD.J.BharaliV.M.AdhamiI.A.SiddiquiH.CuiS.M.Shabanaet al.Oral administration of naturally occurring chitosan-based nanoformulated green tea polyphenol EGCG effectively inhibits prostate cancer cell growth in a xenograft modelCarcinogenesis352014415423
  • I.A.SiddiquiD.J.BharaliM.NihalV.M.AdhamiN.KhanJ.C.Chamcheuet al.Excellent anti-proliferative and pro-apoptotic effects of (-)-epigallocatechin-3-gallate encapsulated in chitosan nanoparticles on human melanoma cell growth both in vitro and in vivoNanomedicine10201416191626
  • L.RayP.KumarK.C.GuptaThe activity against Ehrlich's ascites tumors of doxorubicin contained in self assembled, cell receptor targeted nanoparticle with simultaneous oral delivery of the green tea polyphenol epigallocatechin-3-gallateBiomaterials34201330643076
  • E.RanzatoV.MagnelliS.MartinottiZ.WaheedS.M.CainT.P.Snutchet al.Epigallocatechin-3-gallate elicits Ca2+ spike in MCF-7 breast cancer cells: essential role of Cav3.2 channelsCell Calcium562014285295
  • S.GuptaN.AhmadR.R.MohanM.M.HusainH.MukhtarProstate cancer chemoprevention by green tea: in vitro and in vivo inhibition of testosterone-mediated induction of ornithine decarboxylaseCancer Res59199921152120
  • H.FuJ.HeF.MeiQ.ZhangY.HaraS.Ryotaet al.Lung cancer inhibitory effect of epigallocatechin-3-gallate is dependent on its presence in a complex mixture (polyphenon E)Cancer Prev Res (Phila)22009531537
  • J.KimX.ZhangK.M.Rieger-ChristI.C.SummerhayesD.E.WazerK.E.Paulsonet al.Suppression of Wnt signaling by the green tea compound (-)-epigallocatechin 3-gallate (EGCG) in invasive breast cancer cells. Requirement of the transcriptional repressor HBP1J Biol Chem28120061086510875
  • S.M.MeeranS.N.PatelT.H.ChanT.O.TollefsbolA novel prodrug of epigallocatechin-3-gallate: differential epigenetic hTERT repression in human breast cancer cellsCancer Prev Res (Phila)4201112431254
  • L.MoreiraI.AraujoT.CostaA.Correia-BrancoA.Fariaet al.Quercetin and epigallocatechin gallate inhibit glucose uptake and metabolism by breast cancer cells by an estrogen receptor-independent mechanismExp Cell Res319201317841795
  • T.G.ShutavaS.S.BalkundiP.VangalaJ.J.SteffanR.L.BigelowJ.A.Cardelliet al.Layer-by-layer-coated gelatin nanoparticles as a vehicle for delivery of natural polyphenolsACS Nano3200918771885
  • S.H.TuC.Y.KuC.T.HoC.S.ChenC.S.HuangC.H.Leeet al.Tea polyphenol (-)-epigallocatechin-3-gallate inhibits nicotine- and estrogen-induced alpha9-nicotinic acetylcholine receptor upregulation in human breast cancer cellsMol Nutr Food Res552011455466
  • F.De AmicisA.RussoP.AvenaM.SantoroA.VivacquaD.Bonofiglioet al.In vitro mechanism for downregulation of ER-alpha expression by epigallocatechin gallate in ER+/PR+ human breast cancer cellsMol Nutr Food Res572013840853
  • C.BraicuC.D.GhermanA.IrimieI.Berindan-NeagoeEpigallocatechin-3-Gallate (EGCG) inhibits cell proliferation and migratory behaviour of triple negative breast cancer cellsJ Nanosci Nanotechnol132013632637
  • S.PianettiS.GuoK.T.KavanaghG.E.SonensheinGreen tea polyphenol epigallocatechin-3 gallate inhibits Her-2/neu signaling, proliferation, and transformed phenotype of breast cancer cellsCancer Res622002652655
  • J.Y.JangJ.K.LeeY.K.JeonC.W.KimExosome derived from epigallocatechin gallate treated breast cancer cells suppresses tumor growth by inhibiting tumor-associated macrophage infiltration and M2 polarizationBMC Cancer132013421
  • X.PanB.ZhaoZ.SongS.HanM.WangEstrogen receptor-alpha36 is involved in epigallocatechin-3-gallate induced growth inhibition of ER-negative breast cancer stem/progenitor cellsJ Pharmacol Sci13020168593
  • L.JinC.LiY.XuL.WangJ.LiuD.Wanget al.Epigallocatechin gallate promotes p53 accumulation and activity via the inhibition of MDM2-mediated p53 ubiquitination in human lung cancer cellsOncol Rep29201319831990
  • K.C.KimC.LeeReversal of Cisplatin resistance by epigallocatechin gallate is mediated by downregulation of axl and tyro 3 expression in human lung cancer cellsKorean J Physiol Pharmacol1820146166
  • J.I.SonodaR.IkedaY.BabaK.NarumiA.KawachiE.Tomishigeet al.Green tea catechin, epigallocatechin-3-gallate, attenuates the cell viability of human non-small-cell lung cancer A549 cells via reducing Bcl-xL expressionExp Ther Med820145963
  • H.WangS.BianC.S.YangGreen tea polyphenol EGCG suppresses lung cancer cell growth through upregulating miR-210 expression caused by stabilizing HIF-1alphaCarcinogenesis32201118811889
  • G.X.LiY.K.ChenZ.HouH.XiaoH.JinG.Luet al.Pro-oxidative activities and dose-response relationship of (-)-epigallocatechin-3-gallate in the inhibition of lung cancer cell growth: a comparative study in vivo and in vitroCarcinogenesis312010902910
  • D.SadavaE.WhitlockS.E.KaneThe green tea polyphenol, epigallocatechin-3-gallate inhibits telomerase and induces apoptosis in drug-resistant lung cancer cellsBiochem Biophys Res Commun3602007233237
  • Y.LiT.ZhangY.JiangH.F.LeeS.J.SchwartzD.Sun(-)-Epigallocatechin-3-gallate inhibits Hsp90 function by impairing Hsp90 association with cochaperones in pancreatic cancer cell line Mia Paca-2Mol Pharm6200911521159
  • S.D.RaoK.PagidasEpigallocatechin-3-gallate, a natural polyphenol, inhibits cell proliferation and induces apoptosis in human ovarian cancer cellsAnticancer Res30201025192523
  • C.YanJ.YangL.ShenX.ChenInhibitory effect of Epigallocatechin gallate on ovarian cancer cell proliferation associated with aquaporin 5 expressionArch Gynecol Obstet2852012459467
  • C.W.ChengP.C.ShiehY.C.LinY.J.ChenY.H.LinD.H.Kuoet al.Indoleamine 2,3-dioxygenase, an immunomodulatory protein, is suppressed by (-)-epigallocatechin-3-gallate via blocking of gamma-interferon-induced JAK-PKC-delta-STAT1 signaling in human oral cancer cellsJ Agric Food Chem582010887894
  • A.I.IrimieC.BraicuO.ZanoagaV.PileczkiC.GhermanI.Berindan-Neagoeet al.Epigallocatechin-3-gallate suppresses cell proliferation and promotes apoptosis and autophagy in oral cancer SSC-4 cellsOnco Targets Ther82015461470
  • C.H.LinL.K.ChaoP.H.HungY.J.ChenEGCG inhibits the growth and tumorigenicity of nasopharyngeal tumor-initiating cells through attenuation of STAT3 activationInt J Clin Exp Pathol7201423722381
  • J.MaM.ShiG.LiN.WangJ.WeiT.Wanget al.Regulation of Id1 expression by epigallocatechin3gallate and its effect on the proliferation and apoptosis of poorly differentiated AGS gastric cancer cellsInt J Oncol43201310521058
  • T.TanakaT.IshiiD.MizunoT.MoriR.YamajiY.Nakamuraet al.(-)-Epigallocatechin-3-gallate suppresses growth of AZ521 human gastric cancer cells by targeting the DEAD-box RNA helicase p68Free Radic Biol Med50201113241335
  • Y.ZhangN.D.YangF.ZhouT.ShenT.DuanJ.Zhouet al.(-)-Epigallocatechin-3-gallate induces non-apoptotic cell death in human cancer cells via ROS-mediated lysosomal membrane permeabilizationPLoS One72012e46749
  • G.Y.WubetuM.ShimadaY.MorineT.IkemotoD.IshikawaS.Iwahashiet al.Epigallocatechin gallate hinders human hepatoma and colon cancer sphere formationJ Gastroenterol Hepatol312016256264
  • D.S.AlbrechtE.A.ClubbsM.FerruzziJ.A.BomserEpigallocatechin-3-gallate (EGCG) inhibits PC-3 prostate cancer cell proliferation via MEK-independent ERK1/2 activationChem Biol Interact17120088995
  • R.ShuklaN.ChandaA.ZambreA.UpendranK.KattiR.R.Kulkarniet al.Laminin receptor specific therapeutic gold nanoparticles (198AuNP-EGCg) show efficacy in treating prostate cancerProc Natl Acad Sci U S A10920121242612431
  • S.I.WangH.MukhtarGene expression profile in human prostate LNCaP cancer cells by (-) epigallocatechin-3-gallateCancer Lett18220024351
  • C.P.ChuuR.Y.ChenJ.M.KokontisR.A.HiipakkaS.LiaoSuppression of androgen receptor signaling and prostate specific antigen expression by (-)-epigallocatechin-3-gallate in different progression stages of LNCaP prostate cancer cellsCancer Lett27520098692
  • C.E.HarperB.B.PatelJ.WangI.A.EltoumC.A.LamartiniereEpigallocatechin-3-Gallate suppresses early stage, but not late stage prostate cancer in TRAMP mice: mechanisms of actionProstate67200715761589
  • J.LiS.WuC.WuL.QiuG.ZhuC.Cuiet al.Versatile surface engineering of porous nanomaterials with bioinspired polyphenol coatings for targeted and controlled drug deliveryNanoscale8201686008606
  • N.Y.MinJ.H.KimJ.H.ChoiW.LiangY.J.KoS.Rheeet al.Selective death of cancer cells by preferential induction of reactive oxygen species in response to (-)-epigallocatechin-3-gallateBiochem Biophys Res Commun42120129197
  • H.JinW.GongC.ZhangS.WangEpigallocatechin gallate inhibits the proliferation of colorectal cancer cells by regulating Notch signalingOnco Targets Ther62013145153
  • D.UmedaS.YanoK.YamadaH.TachibanaInvolvement of 67-kDa laminin receptor-mediated myosin phosphatase activation in antiproliferative effect of epigallocatechin-3-O-gallate at a physiological concentration on Caco-2 colon cancer cellsBiochem Biophys Res Commun3712008172176
  • B.HuY.TingX.YangW.TangX.ZengQ.HuangNanochemoprevention by encapsulation of (-)-epigallocatechin-3-gallate with bioactive peptides/chitosan nanoparticles for enhancement of its bioavailabilityChem Commun (Camb)48201224212423
  • J.H.YuanY.Q.LiX.Y.YangInhibition of epigallocatechin gallate on orthotopic colon cancer by upregulating the Nrf2-UGT1A signal pathway in nude micePharmacology802007269278
  • K.OgawaT.HaraM.ShimizuJ.NaganoT.OhnoM.Hoshiet al.(-)-Epigallocatechin gallate inhibits the expression of indoleamine 2,3-dioxygenase in human colorectal cancer cellsOncol Lett42012546550
  • A.AlotaibiP.BhatnagarM.NajafzadehK.C.GuptaD.AndersonTea phenols in bulk and nanoparticle form modify DNA damage in human lymphocytes from colon cancer patients and healthy individuals treated in vitro with platinum-based chemotherapeutic drugsNanomedicine (Lond)82013389401
  • T.SinghS.K.KatiyarGreen tea polyphenol, (-)-epigallocatechin-3-gallate, induces toxicity in human skin cancer cells by targeting beta-catenin signalingToxicol Appl Pharmacol2732013418424
  • S.BalasubramanianG.AdhikaryR.L.EckertThe Bmi-1 polycomb protein antagonizes the (-)-epigallocatechin-3-gallate-dependent suppression of skin cancer cell survivalCarcinogenesis312010496503
  • H.MukhtarM.S.MatsuiD.MaesK.MarenusK.TubesingC.A.ElmetsPrevention by green tea polyphenols against ultraviolet-induced erythema in humansJ Invest Dermatol1061996243