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Original Article

2D QSAR studies of the inhibitory activity of a series of substituted purine derivatives against c-Src tyrosine kinaseFootnote

Pages 563-570 | Received 18 May 2015, Accepted 02 Nov 2015, Published online: 16 Apr 2018

References

  • A.UllrichJ.SchlessingerSignal transduction by receptors with tyrosine kinase activityCell611990203212
  • S.M.ThomasJ.S.BruggeCellular functions regulated by Src family kinasesAnnu. Rev. Cell Dev. Biol.131997513609
  • X.M.YuM.W.SalterSrc, a molecular switch governing gain control of synaptic transmission mediated by N-methyl-D-aspartate receptorsProc. Natl. Acad. Sci. U. S. A.96199976977704
  • S.V.RusselloS.K.ShoreSRC in human carcinogenesisFront. Biosci.92004139144
  • A.Y.TsygankovS.K.ShoreSrc: regulation, role in human carcinogenesis and pharmacological inhibitorsCurr. Pharm. Des.10200417451756
  • T.HunterSignalinge 2000 and beyondCell1002000113127
  • K.A.DeMaliS.L.GodwinS.P.SoltoffA.KazlauskasMultiple roles for Src in a PDGF-stimulated cellExp. Cell. Res.2531999271279
  • F.A.Al-ObeidiJ.J.WuK.S.LamProtein tyrosine kinases: structure, substrate specificity, and drug discoveryBiopolymers471998197223
  • R.RoskoskiJr.Src kinase regulation by phosphorylation and dephosphorylationBiochem. Biophys. Res. Commun.3312005114
  • K.ParangG.SunRecent advances in the discovery of Src kinase inhibitorsExpert Opin. Ther. Patents15200511831207
  • R.B.IrbyT.J.YeatmanRole of Src expression and activation in human cancerOncogene19200056365642
  • A.KurupR.GragD.J.CariniC.HanschComparative QSAR: angiotensin II antagonistsChem. Rev.10120012727
  • C.TintoriM.MagnaniS.SchenoneM.BottaDocking, 3D-QSAR studies and in silico ADME prediction on c-Src tyrosine kinase inhibitorsEur. J. Med. Chem.44March20099901000
  • S.K.BairyB.V.Suneel KumarJ.U.BhallaA.B.PramodM.RavikumarThree dimensional quantitative structure-activity relationship studies on c-Src inhibitors based on different docking methodsChem. Biol. Drug Des.732009416427
  • R.CaoN.MiH.Zhang3D-QSAR study of c-Src kinase inhibitors based on dockingJ. Mol. Model.162010361375
  • H.CaoH.ZhangX.ZhengD.Gao3D QSAR studies on a series of potent and high selective inhibitors for three kinases of RTK familyJ. Mol. Graph. Model.262007236245
  • VLife MDS Software Package, Version 3.52008Supplied by VLife Science Technologies Pvt. Ltd.Pune
  • H.HuangJ.MaJ.ShiL.MengH.JiangJ.DingH.LiuDiscovery of novel purine derivatives with potent and selective inhibitory activity against c-Src tyrosine kinaseBioorg. Med. Chem.18201046154624
  • A.GolbraikhA.TropshaPredictive QSAR modeling based on diversity sampling of experimental datasets for the training and test set selectionJ. Comput. Aided Mol. Des.162002357369
  • T.A.HalgrenMerck molecular force field. III. Molecular geome-tries and vibrational frequencies for MMFF94J. Comput. Chem.171996553586
  • R.D.CramerIIIJ.D.BunceD.E.PattersonCross validation, bootstrapping, and partial least squares compared with multiple regression in conventional QSAR studiesQuant. Struct. Act. Relat.719881825