2,884
Views
35
CrossRef citations to date
0
Altmetric
Reviews

DNA immunization as a technology platform for monoclonal antibody induction

, &
Pages 1-12 | Received 08 Nov 2015, Accepted 15 Dec 2015, Published online: 25 Jan 2019

  • LyonGM,MehtaAK,VarkeyJBet al.Clinical care of two patients with Ebola virus disease in the United States.N Engl J Med2014; 371:2402–2409.
  • UlmerJB,DonnellyJJ,ParkerSEet al.Heterologous protection against influenza by injection of DNA encoding a viral protein.Science1993; 259:1745–1749.
  • FynanEF,WebsterRG,FullerDHet al.DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations.Proc Natl Acad Sci USA1993; 90:11478–11482.
  • WangB,UgenKE,SrikantanVet al.Gene inoculation generates immune responses against human immunodeficiency virus type 1.Proc Natl Acad Sci USA1993; 90:4156–4160.
  • WolffJA,MaloneRW,WilliamsPet al.Direct gene transfer into mouse muscle in vivo.Science1990; 247:1465–1468.
  • JonesS,EvansK,McElwaine-JohnnHet al.DNA vaccination protects against an influenza challenge in a double-blind randomised placebo-controlled phase 1b clinical trial.Vaccine2009; 27:2506–2512.
  • KalamsSA,ParkerSD,ElizagaMet al.Safety and comparative immunogenicity of an HIV-1 DNA vaccine in combination with plasmid interleukin 12 and impact of intramuscular electroporation for delivery.J Infect Dis2013; 208:818–829.
  • LuS.Heterologous prime-boost vaccination.Curr Opin Immunol2009; 21:346–351.
  • WangS,KennedyJS,WestKet al.Cross-subtype antibody and cellular immune responses induced by a polyvalent DNA prime-protein boost HIV-1 vaccine in healthy human volunteers.Vaccine2008; 26:3947–3957.
  • VaineM,WangS,LiuQet al.Profiles of human serum antibody responses elicited by three leading HIV vaccines focusing on the induction of Env-specific antibodies.PLoS One2010; 5:e13916.
  • LedgerwoodJE,WeiCJ,HuZet al.DNA priming and influenza vaccine immunogenicity: two phase 1 open label randomised clinical trials.Lancet Infect Dis2011; 11:916–924.
  • VaineM,WangS,HackettAet al.Antibody responses elicited through homologous or heterologous prime-boost DNA and protein vaccinations differ in functional activity and avidity.Vaccine2010; 28:2999–3007.
  • WangS,ParkerC,TaaffeJet al.Heterologous HA DNA vaccine prime—inactivated influenza vaccine boost is more effective than using DNA or inactivated vaccine alone in eliciting antibody responses against H1 or H3 serotype influenza viruses.Vaccine2008; 26:3626–3633.
  • SuguitanALJr,ChengX,WangWet al.Influenza H5 hemagglutinin DNA primes the antibody response elicited by the live attenuated influenza A/Vietnam/1203/2004 vaccine in ferrets.PLoS One2011; 6:e21942.
  • PalR,WangS,KalyanaramanVSet al.Polyvalent DNA prime and envelope protein boost HIV-1 vaccine elicits humoral and cellular responses and controls plasma viremia in rhesus macaques following rectal challenge with an R5 SHIV isolate.J Med Primatol2005; 34:226–236.
  • WangS,ArthosJ,LawrenceJMet al.Enhanced immunogenicity of gp120 protein when combined with recombinant DNA priming to generate antibodies that neutralize the JR-FL primary isolate of human immunodeficiency virus type 1.J Virol2005; 79:7933–7937.
  • BoyerJD,ChattergoonMA,UgenKEet al.Enhancement of cellular immune response in HIV-1 seropositive individuals: A DNA-based trial.Clin Immunol1999; 90:100–107.
  • BoyerJD,ChattergoonM,ShahAet al.HIV-1 DNA based vaccine induces a CD8 mediated cross-clade CTL response.Dev Biol Stand1998; 95:147–153.
  • CostagliolaS,RodienP,ManyMCet al.Genetic immunization against the human thyrotropin receptor causes thyroiditis and allows production of monoclonal antibodies recognizing the native receptor.J Immunol1998; 160:1458–1465.
  • CostagliolaS,FranssenJD,BonomiMet al.Generation of a mouse monoclonal TSH receptor antibody with stimulating activity.Biochem Biophys Res Commun2002; 299:891–896.
  • NagataS,SalvatoreG,PastanI.DNA immunization followed by a single boost with cells: a protein-free immunization protocol for production of monoclonal antibodies against the native form of membrane proteins.J Immunol Methods2003; 280:59–72.
  • CarsonSD,SwitzerBL,TracySMet al.Monoclonal antibody against mouse CAR following genetic immunization.Hybrid Hybridomics2004; 23:19–22.
  • CostagliolaS,BonomiM,MorgenthalerNGet al.Delineation of the discontinuous-conformational epitope of a monoclonal antibody displaying full in vitro and in vivo thyrotropin activity.Mol Endocrinol2004; 18:3020–3034.
  • AdriouchS,DubberkeG,DiessenbacherPet al.Probing the expression and function of the P2X7 purinoceptor with antibodies raised by genetic immunization.Cell Immunol2005; 236:72–77.
  • BatesMK,ZhangG,SebestyenMGet al.Genetic immunization for antibody generation in research animals by intravenous delivery of plasmid DNA.Biotechniques2006; 40:199–208.
  • FofanaI,KriegerSE,GrunertFet al.Monoclonal anti-claudin 1 antibodies prevent hepatitis C virus infection of primary human hepatocytes.Gastroenterology2010; 139:953–964,64 e1-4.
  • TakatsukaS,SekiguchiA,TokunagaMet al.Generation of a panel of monoclonal antibodies against atypical chemokine receptor CCX-CKR by DNA immunization.J Pharmacol Toxicol Methods2011; 63:250–257.
  • DaftarianP,ChowdhuryR,AmesPet al.In vivo electroporation and non-protein based screening assays to identify antibodies against native protein conformations.Hybridoma (Larchmt)2011; 30:409–418.
  • FofanaI,XiaoF,ThumannCet al.A novel monoclonal anti-CD81 antibody produced by genetic immunization efficiently inhibits Hepatitis C virus cell-cell transmission.PLoS One2013; 8:e64221.
  • HazenM,BhaktaS,VijRet al.An improved and robust DNA immunization method to develop antibodies against extracellular loops of multi-transmembrane proteins.MAbs2014; 6:95–107.
  • GarciaJF,MaestreL,LucasEet al.Genetic immunization: a new monoclonal antibody for the detection of BCL-6 protein in paraffin sections.J Histochem Cytochem2006; 54:31–38.
  • MaestreL,FontanL,Martinez-ClimentJAet al.Generation of a new monoclonal antibody against MALT1 by genetic immunization.Hybridoma (Larchmt)2007; 26:86–91.
  • KilpatrickKE,CutlerT,WhitehornEet al.Gene gun delivered DNA-based immunizations mediate rapid production of murine monoclonal antibodies to the Flt-3 receptor.Hybridoma1998; 17:569–576.
  • WongsenaW,SconocchiaG,ChoHSet al.Production and characterization of monoclonal antibodies against major histocompatibility complex class I chain-related gene A.Tissue Antigens2008; 72:431–440.
  • BradyJL,ManneringSI,KiretaSet al.Monoclonal antibodies generated by DNA immunization recognize CD2 from a broad range of primates.Immunol Cell Biol2009; 87:413–418.
  • XueT,XueXP,HuangQSet al.Monoclonal antibodies against human aspartyl (asparaginyl) beta-hydroxylase developed by DNA immunization.Hybridoma (Larchmt)2009; 28:251–257.
  • ChenY,VaineM,WallaceAet al.A novel rabbit monoclonal antibody platform to dissect the diverse repertoire of antibody epitopes for HIV-1 Env immunogen design.J Virol2013; 87:10232–10243.
  • UlivieriC,BurroniD,TelfordJLet al.1996. Generation of a monoclonal antibody to a defined portion of the Helicobacter pylori vacuolating cytotoxin by DNA immunization.J Biotechnol1996; 51:191–194.
  • ZhangC,JinK,XiaoYet al.Potent monoclonal antibodies against Clostridium difficile toxin A elicited by DNA immunization.Hum Vaccin Immunother2013; 9:2157–2164.
  • YuXF,LiangLH,SheMet al.Production of a monoclonal antibody against SARS-CoV spike protein with single intrasplenic immunization of plasmid DNA.Immunol Lett2005; 100:177–181.
  • PuttikhuntC,KasinrerkW,Srisa-adSet al.Production of anti-dengue NS1 monoclonal antibodies by DNA immunization.J Virol Methods2003; 109:55–61.
  • PupaSM,FortiS,InvernizziAMet al.Monoclonal antibody to fibulin-1 generated by genetic immunization.J Cell Biochem2003; 89:647–652.
  • Koch-NolteF,GlowackiG,BannasPet al.Use of genetic immunization to raise antibodies recognizing toxin-related cell surface ADP-ribosyltransferases in native conformation.Cell Immunol2005; 236:66–71.
  • ChenY,ZhangT,LiTet al.Preparation and characterization of a monoclonal antibody against CKLF1 using DNA immunization with in vivo electroporation.Hybridoma (Larchmt)2005; 24:305–308.
  • LeinonenJ,NiemelaP,LovgrenJet al.Characterization of monoclonal antibodies against prostate specific antigen produced by genetic immunization.J Immunol Methods2004; 289:157–167.
  • CantelliCP,da Gloria Martins TeixeiraM,SantosEAet al.Generation of monoclonal antibodies against human recombinant interferon beta using genetic immunization with simultaneous expression of IgM and IgG isotypes.Hybridoma (Larchmt)2009; 28:211–214.
  • BianC,ZhangF,WangFet al.Development of retinol-binding protein 4 immunocolloidal gold fast test strip using high-sensitivity monoclonal antibodies generated by DNA immunization.Acta Biochim Biophys Sin (Shanghai)2010; 42:847–853.
  • SchmolkeS,TackeM,SchmittUet al.Identification of hepatitis G virus particles in human serum by E2-specific monoclonal antibodies generated by DNA immunization.J Virol1998; 72:4541–4545.
  • HorimotoT,FukudaN,Iwatsuki-HorimotoKet al.Antigenic differences between H5N1 human influenza viruses isolated in 1997 and 2003.J Vet Med Sci2004; 66:303–305.
  • NiY,MaK,NiJet al.A rapid and simple approach to preparation of monoclonal antibody based on DNA immunization.Cell Mol Immunol2004; 1:295–299.
  • Martin-FolgarR,LorenzoG,BoshraHet al.Development and characterization of monoclonal antibodies against Rift Valley fever virus nucleocapsid protein generated by DNA immunization.MAbs2010; 2:275–284.
  • WeiJ,YanB,ChenZet al.Production and characterization of monoclonal antibodies against the hemagglutinin of H5N1 and antigenic investigation of avian influenza H5N1 viruses isolated from China.Can J Microbiol2011; 57:42–48.
  • TanGS,KrammerF,EgginkDet al.A pan-H1 anti-hemagglutinin monoclonal antibody with potent broad-spectrum efficacy in vivo.J Virol2012; 86:6179–6188.
  • VelikovskyCA,CassataroJ,SanchezMet al.Single-shot plasmid DNA intrasplenic immunization for the production of monoclonal antibodies. Persistent expression of DNA.J Immunol Methods2000; 244:1–7.
  • Al-QaoudKM,Al-OmariMM,Al-AghbarMet al.Production of monoclonal antibodies against the 8 kDa subunit of Echinococcus granulosus Antigen B (EgAgB8/2) using DNA immunization.Hybridoma (Larchmt)2008; 27:431–438.
  • OynebratenI,LovasTO,ThompsonKet al.Generation of antibody-producing hybridomas following one single immunization with a targeted DNA vaccine.Scand J Immunol2012; 75:379–388.
  • KilpatrickKE,DangerDP,Hull-RydeEAet al.High-affinity monoclonal antibodies to PED/PEA-15 generated using 5 microg of DNA.Hybridoma2000; 19:297–302.
  • KilpatrickKE,KernerS,DixonEPet al.In vivo expression of a GST-fusion protein mediates the rapid generation of affinity matured monoclonal antibodies using DNA-based immunizations.Hybrid Hybridomics2002; 21:237–243.
  • WangS,Farfan-ArribasDJ,ShenSet al.Relative contributions of codon usage, promoter efficiency and leader sequence to the antigen expression and immunogenicity of HIV-1 Env DNA vaccine.Vaccine2006; 24:4531–4540.
  • GroismanA,SimonnetC,RinbergDPneumatic capillary gun for ballistic delivery of microscopic particles into tissue. US Patent 7892836 B2, February 22, 2011.
  • RobinsonHL,TorresCA.DNA vaccines.Semin Immunol1997; 9:271–283.
  • WangS,JoshiS,LuS.Delivery of DNA to skin by particle bombardment.Methods Mol Biol2004; 245:185–196.
  • AlexandrenneC,WijkhuisenA,DkhissiFet al.Generating antibodies against the native form of the human prion protein (hPrP) in wild-type animals: a comparison between DNA and protein immunizations.J Immunol Methods2009; 341:41–49.
  • WangS,ZhangC,ZhangLet al.The relative immunogenicity of DNA vaccines delivered by the intramuscular needle injection, electroporation and gene gun methods.Vaccine2008; 26:2100–2010.
  • FujimotoA,KosakaN,HasegawaHet al.Enhancement of antibody responses to native G protein-coupled receptors using E. coli GroEL as a molecular adjuvant in DNA immunization.J Immunol Methods2012; 375:243–251.
  • LiW,WangS,LuSPilot Study on the Use of DNA Priming Immunization to Enhance Y. pestis LcrV-Specific B Cell Responses Elicited by a Recombinant LcrV Protein VaccineVaccines (Basel)2013; 2:36–48.
  • PanR,ChenY,VaineMet al.Structural analysis of a novel rabbit monoclonal antibody R53 targeting an epitope in HIV-1 gp120 C4 region critical for receptor and co-receptor binding.Emerg Microbes Infect2015; 4:e44.