- GlennyAT,PopeCG,WaddingtonH,WallaceV.The antigenic value of toxoid precipitated by potassium alum. receptors control activation of adaptive immune responses.J Pathol Bacteriol1926; 29:38–45.
- MaschmannE,KüsterE,FischerW.Über die Fähigkeit des Tonerde-Präparates B, Diphtherie-Toxin zu adsorbieren.Berichte der Deutschen Chemischen Gesellschaft1931; 64:2174–2178.
- EricssonH.Purification and adsorption of diphtheria toxoid.Nature1946; 158:350.
- CooperPD,McCombC,SteeleEJ.The adjuvanticity of Algammulin, a new vaccine adjuvant.Vaccine1991; 9:408–415.
- JankovicD,CasparP,ZweigMet al.Adsorption to aluminum hydroxide promotes the activity of IL-12 as an adjuvant for antibody as well as type 1 cytokine responses to HIV-1 gp120.J Immunol1997; 159:2409–2417.
- PollockKG,ConacherM,WeiXQet al.Interleukin-18 plays a role in both the alum-induced T helper 2 response and the T helper 1 response induced by alum-adsorbed interleukin-12.Immunology2003; 108:137–143.
- WhiteRG,CoonsAH,ConnollyJM.Studies on antibody production. III. The alum granuloma.J Exp Med1955; 102:73–82.
- HoltLB.Developments in Diphtheria Prophylaxis.London: Heinemann.1950.
- HutchisonS,BensonRA,GibsonVBet al.Antigen depot is not required for alum adjuvanticity.FASEB J2012; 26:1272–1279.
- MunksMW,McKeeAS,MacleodMKet al.Aluminum adjuvants elicit fibrin-dependent extracellular traps in vivo.Blood2010; 116:5191–5199.
- HansenB,BelfastM,SoungGet al.Effect of the strength of adsorption of hepatitis B surface antigen to aluminum hydroxide adjuvant on the immune response.Vaccine2009; 27:888–892.
- HansenB,SokolovskaA,HogenEschHet al.Relationship between the strength of antigen adsorption to an aluminum-containing adjuvant and the immune response.Vaccine2007; 25:6618–6624.
- Romero MendezIZ,ShiY,HogenEschHet al.Potentiation of the immune response to non-adsorbed antigens by aluminum-containing adjuvants.Vaccine2007; 25:825–833.
- WatkinsonA,SoliakovA,GanesanAet al.Increasing the potency of an alhydrogel-formulated anthrax vaccine by minimizing antigen-adjuvant interactions.Clin Vaccine Immunol2013; 20:1659–1668.
- JanewayC.Immunobiology: the Immune System in Health and Disease.New York: Garland Science.2005.
- SteinhagenF,KinjoT,BodeCet al.TLR-based immune adjuvants.Vaccine2011; 29:3341–3355.
- SchnareM,BartonGM,HoltACet al.Toll-like receptors control activation of adaptive immune responses.Nat Immunol2001; 2:947–950.
- GavinAL,HoebeK,DuongBet al.Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling.Science2006; 314:1936–1938.
- DavisBK,WenH,TingJP.The inflammasome NLRs in immunity, inflammation, and associated diseases.Annu Rev Immunol2011; 29:707–735.
- SutterwalaFS,HaaskenS,CasselSL.Mechanism of NLRP3 inflammasome activation.Ann NY Acad Sci2014; 1319:82–95.
- LiH,NookalaS,ReF.Aluminum hydroxide adjuvants activate caspase-1 and induce IL-1beta and IL-18 release.J Immunol2007; 178:5271–5276.
- DostertC,GuardaG,RomeroJFet al.Malarial hemozoin is a Nalp3 inflammasome activating danger signal.PLoS One2009; 4:e6510.
- HariA,ZhangY,TuZet al.Activation of NLRP3 inflammasome by crystalline structures via cell surface contact.Sci Rep2014; 4:7281.
- Muñoz-PlanilloR,KuffaP,Martínez-ColónGet al.K (+) efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter.Immunity2013; 38:1142–1153.
- Alfonso-LoechesS,Urena-PeraltaJR,Morillo-BarguesMJet al.Role of mitochondria ROS generation in ethanol-induced NLRP3 inflammasome activation and cell death in astroglial cells.Front Cell Neurosci2014; 8:216.
- ZhouR,YazdiAS,MenuPet al.A role for mitochondria in NLRP3 inflammasome activation.Nature2011; 469:221–225.
- MurakamiT,OckingerJ,YuJet al.Critical role for calcium mobilization in activation of the NLRP3 inflammasome.Proc Natl Acad Sci USA2012; 109:11282–11287.
- LeeGS,SubramanianN,KimAIet al.The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.Nature2012; 492:123–127.
- EisenbarthSC,OscarRC,WilliamOCet al.Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants.Nature2008; 453:1122–1126.
- AndreakosE,WilliamsRO,WalesJet al.Activation of NF-kappaB by the intracellular expression of NF-kappaB-inducing kinase acts as a powerful vaccine adjuvant.Proc Natl Acad Sci USA2006; 103:14459–14464.
- KawaiT,AkiraS.Signaling to NF-kappaB by Toll-like receptors.Trends Mol Med2007; 13:460–469.
- KoolM,PétrilliV,De SmedtTet al.Cutting edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome.J Immunol2008; 181:3755–3759.
- FranchiL,NunezG.The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1beta secretion but dispensable for adjuvant activity.Eur J Immunol2008; 38:2085–2089.
- McKeeAS,MunksMW,MacLeodMKet al.Alum Induces Innate Immune Responses through Macrophage and Mast Cell Sensors, But These Sensors Are Not Required for Alum to Act As an Adjuvant for Specific Immunity.J Immunol2009; 183:4403–4414.
- FlachTL,NgG,HariAet al.Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity.Nat Med2011; 17:479–487.
- MatzingerP.Tolerance, danger, and the extended family.Annu Rev Immunol1994; 12:991–1045.
- ShiY,EvansJE,RockKL.Molecular identification of a danger signal that alerts the immune system to dying cells.Nature2003; 425:516–521.
- RockKL.The ins and outs of cross-presentation.Nat Immunol2003; 4:941–943.
- LimaHJr,JacobsonLS,GoldbergMFet al.Role of lysosome rupture in controlling Nlrp3 signaling and necrotic cell death.Cell Cycle2013; 12:1868–1878.
- FinkSL,CooksonBT.Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells.Infect Immun2005; 73:1907–1916.
- McKeeAS,BurchillMA,MunksMWet al.Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells.Proc Natl Acad Sci USA2013; 110:31.
- MarichalT,OhataK,BedoretDet al.DNA released from dying host cells mediates aluminum adjuvant activity.Nat Med2011; 17:996–1002.
- RathinamVA,JiangZ,WaggonerSNet al.The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses.Nat Immunol2010; 11:395–402.
- HornungV,AblasserA,Charrel-DennisMet al.AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC.Nature2009; 458:514–518.
- BurdetteDL,MonroeKM,Sotelo-TrohaKet al.STING is a direct innate immune sensor of cyclic di-GMP.Nature2011; 478:515–518.
- GaoD,WuJ,WuYTet al.Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses.Science2013; 341:903–906.
- SunL,WuJ,DuF,ChenXet al.Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.Science2013; 339:786–791.
- McKeeAS,BurchillMA,MunksMWet al.Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells.Proc Natl Acad Sci USA2013; 110:E1122–E1131.
- KoolM,SoulliéT,van NimwegenMet al.Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells.J Exp Med2008; 205:869–882.
- ShiY,GalushaSA,RockKL.Cutting edge: elimination of an endogenous adjuvant reduces the activation of CD8 T lymphocytes to transplanted cells and in an autoimmune diabetes model.J Immunol2006; 176:3905–3908.
- HariA,GangulyA,MuLet al.Redirecting soluble antigen for MHC class I cross-presentation during phagocytosis.Eur J Immunol2015; 45:383–395.
- XuDZ,HuangKL,ZhaoKet al.Vaccination with recombinant HBsAg-HBIG complex in healthy adults.Vaccine2005; 23:2658–2664.
- XuDZ,ZhaoK,GuoLMet al.A randomized controlled phase IIb trial of antigen-antibody immunogenic complex therapeutic vaccine in chronic hepatitis B patients.PLoS One2008; 3:e2565.
- XuDZ,WangXY,ShenXLet al.Results of a phase III clinical trial with an HBsAg-HBIG immunogenic complex therapeutic vaccine for chronic hepatitis B patients: experiences and findings.J Hepatol2013; 59:450–456.
- WangXY,YaoX,WanYMet al.Responses to multiple injections with alum alone compared to injections with alum adsorbed to proteins in mice.Immunol Lett2013; 149:88–92.
- MeleroI,GaudernackG,GerritsenWet al.Therapeutic vaccines for cancer: an overview of clinical trials.Nat Rev Clin Oncol2014; 11:509–524.
- WangB,WangX,WenYet al.Suppression of established hepatocarcinoma in adjuvant only immunotherapy: alum triggers anti-tumor CD8(+) T cell response.Sci Rep2015; 5:17695.
- RimaniolAC,GrasG,VerdierFet al.Aluminum hydroxide adjuvant induces macrophage differentiation towards a specialized antigen-presenting cell type.Vaccine2004; 22:3127–3135.
- El SahlyH.MF59TM; as a vaccine adjuvant: a review of safety and immunogenicity.Expert Rev Vaccines2010; 9:1135–1141.
- Sánchez VallecilloMF,Minguito de la EscaleraMM,AguirreMVet al.A liquid crystal of ascorbyl palmitate, used as vaccine platform, provides sustained release of antigen and has intrinsic pro-inflammatory and adjuvant activities which are dependent on MyD88 adaptor protein.J Control Release2015; 214:12–22.
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Alum: an old dog with new tricks
Yumei WenKey Laboratory of Molecular Medical Virology, MOE/MOH, Shanghai Medical College, Fudan University, Shanghai200032, ChinaCorrespondence[email protected]
& Yan ShiDepartment of Basic Medical Sciences, Institute of Immunology, Center for Life Sciences, Tsinghua University, Beijing100084, China;Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, CalgaryT2N 4N1, Alberta, CanadaCorrespondence[email protected]
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Received 29 Nov 2015, Accepted 22 Dec 2015, Published online: 25 Jan 2019
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