Clinical features and viral quasispecies characteristics associated with infection by the hepatitis B virus G145R immune escape mutant

References

• Galati G, De Vincentis A, Vespasiani-Gentilucci Uet al.Coexistence of HBsAg and HBsAb in a difficult-to-treat chronic hepatitis B: loss of HBsAg with entecavir plus tenofovir combination. BMC Gastroenterol 2014;14: 94.
   PubMed Web of Science ®Google Scholar
• Lada O, Benhamou Y, Poynard Tet al.Coexistence of hepatitis B surface antigen (HBs Ag) and anti-HBs antibodies in chronic hepatitis B virus carriers: influence of 'a' determinant variants. J Virol 2006;80: 2968–2975.
   PubMed Web of Science ®Google Scholar
• Zhang JM, Xu Y, Wang XYet al.Coexistence of hepatitis B surface antigen (HBsAg) and heterologous subtype-specific antibodies to HBsAg among patients with chronic hepatitis B virus infection. Clin Infect Dis 2007;44: 1161–1169.
   PubMed Web of Science ®Google Scholar
• Yu DM, Li XH, Mom Vet al.N-glycosylation mutations within hepatitis B virus surface major hydrophilic region contribute mostly to immune escape. J Hepatol 2014;60: 515–522.
   PubMed Web of Science ®Google Scholar
• Liu W, Hu T, Wang Xet al.Coexistence of hepatitis B surface antigen and anti-HBs in Chinese chronic hepatitis B virus patients relating to genotype C and mutations in the S and P gene reverse transcriptase region. Arch Virol 2012;157: 627–634.
   PubMed Web of Science ®Google Scholar
• Bian T, Yan H, Shen Let al.Change in hepatitis B virus large surface antigen variant prevalence 13 years after implementation of a universal vaccination program in China. J Virol 2013;87: 12196–12206.
   PubMed Web of Science ®Google Scholar
• Thakur V, Kazim SN, Guptan RCet al.Transmission of G145R mutant of HBV to an unrelated contact. J Med Virol 2005;76: 40–46.
   PubMed Web of Science ®Google Scholar
• Turner FS.Assessment of insert sizes and adapter content in fastq data from NexteraXT libraries. Front Genet 2014;5: 5.
   PubMed Web of Science ®Google Scholar
• Langmead B, Salzberg SL.Fast gapped-read alignment with Bowtie 2. Nat Methods 2012;9: 357–359.
   PubMed Web of Science ®Google Scholar
• Li H, Handsaker B, Wysoker Aet al.The Sequence alignment/Map format and SAMtools. Bioinformatics 2009;25: 2078–2079.
   PubMed Web of Science ®Google Scholar
• Zagordi O, Klein R, Daumer Met al.Error correction of next-generation sequencing data and reliable estimation of HIV quasispecies. Nucleic Acids Res 2010;38: 7400–7409.
   PubMed Web of Science ®Google Scholar
• Liu F, Chen L, Yu DMet al.Evolutionary patterns of hepatitis B virus quasispecies under different selective pressures: correlation with antiviral efficacy. Gut 2011;60: 1269–1277.
   PubMed Web of Science ®Google Scholar
• Chen L, Zhang Q, Yu DMet al.Early changes of hepatitis B virus quasispecies during lamivudine treatment and the correlation with antiviral efficacy. J Hepatol 2009;50: 895–905.
   PubMed Web of Science ®Google Scholar
• Tamura K, Stecher G, Peterson Det al.MEGA6: molecular evolutionary genetics analysis version 6.0. Mol Biol Evol 2013;30: 2725–2729.
   PubMed Web of Science ®Google Scholar
• Yamani LN, Yano Y, Utsumi Tet al.Ultradeep sequencing for detection of quasispecies variants in the major hydrophilic region of hepatitis B virus in Indonesian patients. J Clin Microbiol 2015;53: 3165–3175.
   PubMed Web of Science ®Google Scholar
• Khedive A, Norouzi M, Ramezani Fet al.Hepatitis B virus surface protein mutations clustered mainly in CTL immune epitopes in chronic carriers: results of an Iranian nationwide study. J Viral Hepat 2013;20: 494–501.
   PubMed Web of Science ®Google Scholar
• Honorati MC, Dolzani P, Mariani Eet al.Epitope specificity of Th0/Th2 CD4+ T-lymphocyte clones induced by vaccination with rHBsAg vaccine. Gastroenterology 1997;112: 2017–2027.
   PubMed Web of Science ®Google Scholar
• Pancher M, Desire N, Ngo Yet al.Coexistence of circulating HBsAg and anti-HBs antibodies in chronic hepatitis B carriers is not a simple analytical artifact and does not influence HBsAg quantification. J Clin Virol 2015;62: 32–37.
   PubMed Web of Science ®Google Scholar
• Pu Z, Li D, Wang Aet al.Epidemiological characteristics of the carriers with coexistence of HBsAg and anti-HBs based on a community cohort study. J Viral Hepat 2016;23: 286–293.
   PubMed Web of Science ®Google Scholar
• Seo SI, Choi HS, Choi BYet al.Coexistence of hepatitis B surface antigen and antibody to hepatitis B surface may increase the risk of hepatocellular carcinoma in chronic hepatitis B virus infection: a retrospective cohort study. J Med Virol 2014;86: 124–130.
   PubMed Web of Science ®Google Scholar
• Wu C, Deng W, Deng Let al.Amino acid substitutions at positions 122 and 145 of hepatitis B virus surface antigen (HBsAg) determine the antigenicity and immunogenicity of HBsAg and influence in vivo HBsAg clearance. J Virol 2012;86: 4658–4669.
   PubMed Web of Science ®Google Scholar
• Ye Q, Shang SQ, Li W.A new vaccine escape mutant of hepatitis B virus causes occult infection. Hum Vaccin Immunother 2015;11: 407–410.
   PubMed Web of Science ®Google Scholar
• Ding F, Yu HG, Li YXet al.Sequence analysis of the HBV S protein in Chinese patients with coexisting HBsAg and anti-HBs antibodies. J Med Virol 2015;87: 2067–2073.
   PubMed Web of Science ®Google Scholar
• Han Y, Gong L, Sheng Jet al.Prediction of virological response by pretreatment hepatitis B virus reverse transcriptase quasispecies heterogeneity: the advantage of using next-generation sequencing. Clin Microbiol Infect 2015;21: e791–e798.
   PubMed Web of Science ®Google Scholar
• Lavocat F, Deny P, Pichoud Cet al.Similar evolution of hepatitis B virus quasispecies in patients with incomplete adefovir response receiving tenofovir/emtricitabine combination or tenofovir monotherapy. J Hepatol 2013;59: 684–695.
   PubMed Web of Science ®Google Scholar
• Zhou B, Dong H, He Yet al.Composition and interactions of hepatitis B virus quasispecies defined the virological response during telbivudine therapy. Sci Rep 2015;5: 17123.
   PubMed Web of Science ®Google Scholar
• Vignuzzi M, Stone JK, Arnold JJet al.Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population. Nature 2006;439: 344–348.
   PubMed Web of Science ®Google Scholar
• Amini-Bavil-Olyaee S, Vucur M, Luedde Tet al.Differential impact of immune escape mutations G145R and P120T on the replication of lamivudine-resistant hepatitis B virus e antigen-positive and -negative strains. J Virol 2010;84: 1026–1033.
   PubMed Web of Science ®Google Scholar