2,294
Views
33
CrossRef citations to date
0
Altmetric
Original Articles

Propionibacterium acnes induces intervertebral disc degeneration by promoting nucleus pulposus cell apoptosis via the TLR2/JNK/mitochondrial-mediated pathway

, , , , , , ORCID Icon, & show all
Pages 1-8 | Received 08 Jul 2017, Accepted 31 Oct 2017, Published online: 10 Jan 2018

References

  • ModicMTRossJSLumbar degenerative disk diseaseRadiology2007245 43 6110.1148/radiol.2451051706
  • ChenZOverview: the role of Propionibacterium acnes in nonpyogenic intervertebral discsInt. Orthop.2016401291129810.1007/s00264-016-3115-5
  • CapoorMNPropionibacterium acnes biofilm is present in intervertebral discs of patients undergoing microdiscectomyPLoS ONE201712e017451810.1371/journal.pone.01745185378350
  • StirlingAWorthingtonTRafiqMLambertPAElliottTSAssociation between sciatica and Propionibacterium acnesLancet20013572024202510.1016/S0140-6736(00)05109-6
  • CosciaMFDenysGAWackMFPropionibacterium acnes, coagulase-negative Staphylococcus, and the “Biofilm-like” intervertebral discSpine2016411860186510.1097/BRS.00000000000019095158091
  • RaoPJDISC (Degenerate-disc Infection Study With Contaminant Control): pilot study of Australian cohort of patients without the contaminant controlSpine20164193593910.1097/BRS.0000000000001404
  • AlbertHBDoes nuclear tissue infected with bacteria following disc herniations lead to Modic changes in the adjacent vertebrae?Eur. Spine J.20132269069610.1007/s00586-013-2674-z3631023
  • Chen Z. et al. Modic changes and disc degeneration caused by inoculation of Propionibacterium acnes inside intervertebral discs of rabbits: a pilot study. Biomed. Res. Int.2016, 9612437 (2016).
  • ZhouZRelationship between annular tear and presence of Propionibacterium acnes in lumbar intervertebral discEur. Spine J.2015242496250210.1007/s00586-015-4180-y
  • DudliSPropionibacterium acnes infected intervertebral discs cause vertebral bone marrow lesions consistent with Modic changesJ. Orthop. Res.2016341447145510.1002/jor.23265
  • LiBAssociation between lumbar disc degeneration and Propionibacterium acnes infection: clinical research and preliminary exploration of animal experimentSpine201641E764E76910.1097/BRS.0000000000001383
  • PerryALambertPPropionibacterium acnes: infection beyond the skinExpert. Rev. Anti. Infect. Ther.201191149115610.1586/eri.11.137
  • YuanYHistological identification of Propionibacterium acnes in nonpyogenic degenerated intervertebral discsBiomed. Res Int2017201761929355376442
  • YamadaKCaspase 3 silencing inhibits biomechanical overload-induced intervertebral disk degenerationAm. J. Pathol.201418475376410.1016/j.ajpath.2013.11.010
  • DingFShaoZWXiongLMCell death in intervertebral disc degenerationApoptosis20131877778510.1007/s10495-013-0839-1
  • ZhaoCQJiangLSDaiLYProgrammed cell death in intervertebral disc degenerationApoptosis2006112079208810.1007/s10495-006-0290-7
  • DingFRole of mitochondrial pathway in compression-induced apoptosis of nucleus pulposus cellsApoptosis20121757959010.1007/s10495-012-0708-3
  • O’DonnellMJGlobal and regional effects of potentially modifiable risk factors associated with acute stroke in 32 countries (INTERSTROKE): a case-control studyLancet201638876177510.1016/S0140-6736(16)30506-2
  • FrobinWBrinckmannPKramerMHartwigEHeight of lumbar discs measured from radiographs compared with degeneration and height classified from MR imagesEur. Radiol.20011126326910.1007/s003300000556
  • SuQGrabowskiMWeindlGRecognition of Propionibacterium acnes by human TLR2 heterodimersInt. J. Med. Microbiol.201730710811210.1016/j.ijmm.2016.12.002
  • Alva-MurilloNOchoa-ZarzosaALopez-MezaJESodium octanoate modulates the innate immune response of bovine mammary epithelial cells through the TLR2/P38/JNK/ERK1/2 pathway: implications during Staphylococcus aureus internalizationFront. Cell Infect. Microbiol.201777810.3389/fcimb.2017.000785350129
  • ZhangSJAutophagy: a double-edged sword in intervertebral disk degenerationClin. Chim. Acta2016457273510.1016/j.cca.2016.03.016
  • SvenningSJohansenTSelective autophagyEssays Biochem.201355799210.1042/bse0550079
  • BauckmanKAOwusu-BoaiteyNMysorekarIUSelective autophagy: xenophagyMethods20157512012710.1016/j.ymeth.2014.12.005
  • SalminenAKaarnirantaKKauppinenABeclin 1 interactome controls the crosstalk between apoptosis, autophagy and inflammasome activation: impact on the aging processAgeing Res. Rev.20131252053410.1016/j.arr.2012.11.004
  • AgarwalVGolishSRAlaminTFBacteriologic culture of excised intervertebral disc from immunocompetent patients undergoing single level primary lumbar microdiscectomyJ. Spinal Disord. Tech.20112439740010.1097/BSD.0b013e3182019f3a
  • McLorinanGCGlennJVMcMullanMGPatrickSPropionibacterium acnes wound contamination at the time of spinal surgeryClin. Orthop. Relat. Res.2005437677310.1097/00003086-200508000-00012
  • CapoorMNPrevalence of Propionibacterium acnes in intervertebral discs of patients undergoing lumbar microdiscectomy: a prospective cross-sectional studyPLoS ONE201611e016167610.1371/journal.pone.01616764990245
  • LeeWRProtective effect of melittin against inflammation and apoptosis on Propionibacterium acnes-induced human THP-1 monocytic cellEur. J. Pharmacol.201474021822610.1016/j.ejphar.2014.06.058
  • UchidaTInvolvement of CD14 in lipopolysaccharide- induced liver injury in mice pretreated with Propionibacterium acnesPathobiology20047124625210.1159/000080058
  • JiangLApoptosis, senescence, and autophagy in rat nucleus pulposus cells: Implications for diabetic intervertebral disc degenerationJ. Orthop. Res.20133169270210.1002/jor.22289
  • LeckieSKInjection of AAV2-BMP2 and AAV2-TIMP1 into the nucleus pulposus slows the course of intervertebral disc degeneration in an in vivo rabbit modelSpine J.20121272010.1016/j.spinee.2011.09.011
  • YangRBToll-like receptor-2 mediates lipopolysaccharide-induced cellular signallingNature199839528428810.1038/26239
  • YoshimuraACutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2J. Immunol.199916315
  • KimJActivation of toll-like receptor 2 in acne triggers inflammatory cytokine responsesJ. Immunol.20021691535154110.4049/jimmunol.169.3.15354636337
  • QueroLHyaluronic acid fragments enhance the inflammatory and catabolic response in human intervertebral disc cells through modulation of toll-like receptor 2 signalling pathwaysArthritis Res. Ther.201315R9410.1186/ar42743978638
  • KimTSKimYSYooHParkYKJoEKMycobacterium massiliense induces inflammatory responses in macrophages through Toll-like receptor 2 and c-Jun N-terminal kinaseJ. Clin. Immunol.20143421222310.1007/s10875-013-9978-y3937545
  • KawaiTAkiraSTLR signalingCell Death Differ.20061381682510.1038/sj.cdd.4401850
  • WagnerEFNebredaARSignal integration by JNK and p38 MAPK pathways in cancer developmentNat. Rev. Cancer2009953754910.1038/nrc2694
  • JanssensSBurnsKVercammenETschoppJBeyaertRMyD88S, a splice variant of MyD88, differentially modulates NF-kappaB- and AP-1-dependent gene expressionFEBS Lett.200354810310710.1016/S0014-5793(03)00747-6
  • DhanasekaranDNReddyEPJNK signaling in apoptosisOncogene2008276245665110.1038/onc.2008.3013063296
  • KuoYJMechanical stress-induced apoptosis of nucleus pulposus cells: an in vitro and in vivo rat modelJ. Orthop. Sci.20141931332210.1007/s00776-013-0510-2
  • WeiMCProapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and deathScience200129272773010.1126/science.10591083049805
  • MadeshMAntonssonBSrinivasulaSMAlnemriESHajnoczkyGRapid kinetics of tBid-induced cytochrome c and Smac/DIABLO release and mitochondrial depolarizationJ. Biol. Chem.20022775651565910.1074/jbc.M108171200
  • GreenDRReedJCMitochondria and apoptosisScience19982811309131210.1126/science.281.5381.1309
  • NakamuraTAutophagy induced by intracellular infection of Propionibacterium acnesPLoS. One.201611e015629810.1371/journal.pone.01562984878785
  • GomesLCDikicIAutophagy in antimicrobial immunityMol. Cell20145422423310.1016/j.molcel.2014.03.009
  • JiangWSIRT1 protects against apoptosis by promoting autophagy in degenerative human disc nucleus pulposus cellsSci. Rep.2014410.1038/srep074564264007
  • ChenJWThe responses of autophagy and apoptosis to oxidative stress in nucleus pulposus cells: implications for disc degenerationCell Physiol. Biochem.2014341175118910.1159/000366330
  • LevineBSinhaSCKroemerGBcl-2 family members: dual regulators of apoptosis and autophagyAutophagy2008460060610.4161/auto.62602749577
  • FreemontAJThe cellular pathobiology of the degenerate intervertebral disc and discogenic back painRheumatology20094851010.1093/rheumatology/ken396