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Review Article

Advances in the diagnosis and treatment of Clostridium difficile infections

Zhong PengState Key Laboratory of Agricultural Microbiology, College of Veterinary MedicineHuazhong Agricultural University430070WuhanHubeiChina

http://orcid.org/0000-0001-5249-328X

Lifen LingThe Eighth Affiliated Hospital of Sun Yat-sen University518000ShenzhenGuangdongChina;Department of Laboratory MedicineMemorial Sloan Kettering Cancer Center10065New YorkNYUSA

Charles W. StrattonDepartment of Pathology, Microbiology and ImmunologyVanderbilt University Medical Center37232NashvilleTNUSA

Chunhui LiInfection Control CenterXiangya Hospital of Central South University410008ChangshaHunanChina

Christopher R. PolageDepartments of Pathology and Laboratory Medicine and Internal MedicineUniversity of California Davis School of Medicine95817SacramentoCAUSA

Bin WuState Key Laboratory of Agricultural Microbiology, College of Veterinary MedicineHuazhong Agricultural University430070WuhanHubeiChina

Yi-Wei TangDepartment of Laboratory MedicineMemorial Sloan Kettering Cancer Center10065New YorkNYUSA;Department of Pathology and Laboratory MedicineWeill Medical College of Cornell University10065New YorkNYUSACorrespondence[email protected]

http://orcid.org/0000-0003-4888-6771

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Pages 1-13 | Received 06 Nov 2017, Accepted 27 Dec 2017, Published online: 07 Feb 2018

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https://doi.org/10.1038/s41426-017-0019-4
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References

LefflerDALamontJTClostridium difficile infectionN. Engl. J. Med.2015372 1539 154810.1056/NEJMra1403772
PubMed Web of Science ®Google Scholar
NapolitanoLMEdmistonCEJr.Clostridium difficile disease: diagnosis, pathogenesis, and treatment updateSurgery201716232534810.1016/j.surg.2017.01.018
PubMed Web of Science ®Google Scholar
Shin, J. H., Chaves-Olarte, E. & Warren, C. A. Clostridium difficile infection. Microbiol. Spectr.4, 10.1128/microbiolspec.EI10-0007-2015 (2016).
Google Scholar
LessaFCGouldCVMcDonaldLCCurrent status of Clostridium difficile infection epidemiologyClin. Infect. Dis.201255Suppl. 2S65S7010.1093/cid/cis3193388017
PubMed Web of Science ®Google Scholar
CohenSHClinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the society for healthcare epidemiology of America (SHEA) and the infectious diseases society of America (IDSA)Infect. Control Hosp. Epidemiol.20103143145510.1086/651706
PubMed Web of Science ®Google Scholar
BauerMPKuijperEJvan DisselJTEuropean Society of Clinical Microbiology and Infectious Diseases (ESCMID): treatment guidance document for Clostridium difficile infection (CDI)Clin. Microbiol. Infect.2009151067107910.1111/j.1469-0691.2009.03099.x
PubMed Web of Science ®Google Scholar
DebastSBBauerMPKuijperEJEuropean Society of Clinical Microbiology and Infectious Diseases: update of the treatment guidance document for Clostridium difficile infectionClin. Microbiol. Infect.201420Suppl. 212610.1111/1469-0691.12418
PubMed Web of Science ®Google Scholar
SpigagliaPRecent advances in the understanding of antibiotic resistance in Clostridium difficile infectionTher. Adv. Infect. Dis.20163234210.1177/20499361156228914735502
PubMed Web of Science ®Google Scholar
PengZUpdate on antimicrobial resistance in Clostridium difficile: resistance mechanisms and antimicrobial susceptibility testingJ. Clin. Microbiol.2017551998200810.1128/JCM.02250-165483901
PubMed Web of Science ®Google Scholar
CrobachMJEuropean Society of Clinical Microbiology and Infectious Diseases: update of the diagnostic guidance document for Clostridium difficile infectionClin. Microbiol. Infect.201622Suppl. 4S63S8110.1016/j.cmi.2016.03.010
PubMed Web of Science ®Google Scholar
GerdingDNFileTMJrMcDonaldLCDiagnosis and treatment of Clostridium difficile infectionInfect. Dis. Clin. Pract.20162431010.1097/IPC.0000000000000350
PubMed Web of Science ®Google Scholar
CarrollKCBartlettJGBiology of Clostridium difficile: implications for epidemiology and diagnosisAnnu. Rev. Microbiol.20116550152110.1146/annurev-micro-090110-102824
PubMed Web of Science ®Google Scholar
HuangBReal-time cellular analysis coupled with a specimen enrichment accurately detects and quantifies Clostridium difficile toxins in stoolJ. Clin. Microbiol.2014521105111110.1128/JCM.02601-133993479
PubMed Web of Science ®Google Scholar
Jin, D. et al. Molecular epidemiology of Clostridium difficile infection in hospitalized patients in Eastern China. J. Clin. Microbiol.55, 801–810 (2017).
Google Scholar
ChowWHApplication of isothermal helicase-dependent amplification with a disposable detection device in a simple sensitive stool test for toxigenic Clostridium difficile J. Mol. Diagn.20081045245810.2353/jmoldx.2008.0800082518740
PubMed Web of Science ®Google Scholar
RyderABAssessment of Clostridium difficile infections by quantitative detection of tcdB toxin by use of a real-time cell analysis systemJ. Clin. Microbiol.2010484129413410.1128/JCM.01104-103020809
PubMed Web of Science ®Google Scholar
Murad, Y. M. et al. False negative results in Clostridium difficile testing. BMC Infect. Dis.16, 430 (2016).
Google Scholar
MerzCSComparison of four commercially available rapid enzyme immunoassays with cytotoxin assay for detection of Clostridium difficile toxin(s) from stool specimensJ. Clin. Microbiol.19943211421147263625
PubMed Web of Science ®Google Scholar
KociolekLKStrategies for optimizing the diagnostic predictive value of Clostridium difficile molecular diagnosticsJ. Clin. Microbiol.2017551244124810.1128/JCM.00147-175405242
PubMed Web of Science ®Google Scholar
PlancheTWilcoxMHDiagnostic pitfalls in Clostridium difficile infectionInfect. Dis. Clin. North Am.201529638210.1016/j.idc.2014.11.008
PubMed Web of Science ®Google Scholar
BarbutFDoes a rapid diagnosis of Clostridium difficile infection impact on quality of patient management?Clin. Microbiol. Infect.20142013614410.1111/1469-0691.12221
PubMed Web of Science ®Google Scholar
Dunwoody, R., Steel, A., Landy, J. & Simmonds, N. Clostridium difficile and cystic fibrosis: management strategies and the role of faecal transplantation. Paediatr. Respir. Rev. doi:10.1016/j.prrv.2017.03.003 (2017).
Google Scholar
BurnhamCACarrollKCDiagnosis of Clostridium difficile infection: an ongoing conundrum for clinicians and for clinical laboratoriesClin. Microbiol. Rev.20132660463010.1128/CMR.00016-133719497
PubMed Web of Science ®Google Scholar
SurawiczCMGuidelines for diagnosis, treatment, and prevention of Clostridium difficile infectionsAm. J. Gastroenterol.201310847849810.1038/ajg.2013.4
PubMed Web of Science ®Google Scholar
SchroederLFRobilottiEPetersonLRBanaeiNDowdyDWEconomic evaluation of laboratory testing strategies for hospital-associated Clostridium difficile infectionJ. Clin. Microbiol.20145248949610.1128/JCM.02777-133911327
PubMed Web of Science ®Google Scholar
ChenSGuHSunCWangHWangJRapid detection of Clostridium difficile toxins and laboratory diagnosis of Clostridium difficile infectionsInfection20174525526210.1007/s15010-016-0940-9
PubMed Web of Science ®Google Scholar
GerdingDNJohnsonSRupnikMAktoriesKClostridium difficile binary toxin CDT: mechanism, epidemiology, and potential clinical importanceGut Microbes20145152710.4161/gmic.26854
PubMed Web of Science ®Google Scholar
GilliganPHOptimizing the laboratory diagnosis of Clostridium difficile infectionClin. Lab. Med.20153529931210.1016/j.cll.2015.02.003
PubMed Web of Science ®Google Scholar
SmitsWKLyrasDLacyDBWilcoxMHKuijperEJClostridium difficile infectionNat. Rev. Dis. Primers201621602010.1038/nrdp.2016.205453186
PubMed Web of Science ®Google Scholar
Martinez-MelendezACurrent knowledge on the laboratory diagnosis of Clostridium difficile infectionWorld J. Gastroenterol.2017231552156710.3748/wjg.v23.i9.15525340807
PubMed Web of Science ®Google Scholar
DeshpandeADiagnostic accuracy of real-time polymerase chain reaction in detection of Clostridium difficile in the stool samples of patients with suspected Clostridium difficile Infection: a meta-analysisClin. Infect. Dis.201153e81e9010.1093/cid/cir505
PubMed Web of Science ®Google Scholar
StockmannCHow well does physician selection of microbiologic tests identify Clostridium difficile and other pathogens in paediatric diarrhoea? Insights using multiplex PCR-based detectionClin. Microbiol. Infect.201521179.e17911510.1016/j.cmi.2014.07.011
Web of Science ®Google Scholar
BeckmannCHeiningerUMartiHHirschHHGastrointestinal pathogens detected by multiplex nucleic acid amplification testing in stools of pediatric patients and patients returning from the tropicsInfection20144296197010.1007/s15010-014-0656-7
PubMed Web of Science ®Google Scholar
PolageCROutcomes in patients tested for Clostridium difficile toxinsDiagn. Microbiol. Infect. Dis.20127436937310.1016/j.diagmicrobio.2012.08.0193496840
PubMed Web of Science ®Google Scholar
PolageCROverdiagnosis of Clostridium difficile infection in the molecular test eraJAMA Intern. Med.20151751792180110.1001/jamainternmed.2015.41144948649
PubMed Web of Science ®Google Scholar
KociolekLKImpact of a healthcare provider educational intervention on frequency of Clostridium difficile polymerase chain reaction testing in children: a segmented regression analysisJ. Pediatr. Infect. Dis. Soc.20176142148
PubMed Web of Science ®Google Scholar
LeslieJLCohenSHSolnickJVPolageCRRole of fecal Clostridium difficile load in discrepancies between toxin tests and PCR: is quantitation the next step in C. difficile testing?Eur. J. Clin. Microbiol. Infect. Dis.2012313295329910.1007/s10096-012-1695-63753214
PubMed Web of Science ®Google Scholar
TruongCYReal-time electronic tracking of diarrheal episodes and laxative therapy enables verification of Clostridium difficile clinical testing criteria and reduction of Clostridium difficile infection ratesJ. Clin. Microbiol.2017551276128410.1128/JCM.02319-165405247
PubMed Web of Science ®Google Scholar
SenchynaFClostridium difficile PCR cycle threshold predicts free toxinJ. Clin. Microbiol.2017552651266010.1128/JCM.00563-17
PubMed Web of Science ®Google Scholar
Avila, M. B., Avila, N. P. & Dupont, A. W. Recent advances in the diagnosis and treatment of Clostridium difficile infection. F1000Research5, 10.12688/f1000research.7109.1 (2016).
Google Scholar
ManzoorSEExtended multilocus variable-number tandem-repeat analysis of Clostridium difficile correlates exactly with ribotyping and enables identification of hospital transmissionJ. Clin. Microbiol.2011493523353010.1128/JCM.00546-113187294
PubMed Web of Science ®Google Scholar
KillgoreGComparison of seven techniques for typing international epidemic strains of Clostridium difficile: restriction endonuclease analysis, pulsed-field gel electrophoresis, PCR-ribotyping, multilocus sequence typing, multilocus variable-number tandem-repeat analysis, amplified fragment length polymorphism, and surface layer protein A gene sequence typingJ. Clin. Microbiol.20084643143710.1128/JCM.01484-07
PubMed Web of Science ®Google Scholar
LemeeLMultilocus sequence analysis and comparative evolution of virulence-associated genes and housekeeping genes of Clostridium difficileMicrobiology20051513171318010.1099/mic.0.28155-0
PubMed Web of Science ®Google Scholar
LemeeLDhalluinAPestel-CaronMLemelandJFPonsJLMultilocus sequence typing analysis of human and animal Clostridium difficile isolates of various toxigenic typesJ. Clin. Microbiol.2004422609261710.1128/JCM.42.6.2609-2617.2004427854
PubMed Web of Science ®Google Scholar
van den BergRJSchaapITempletonKEKlaassenCHKuijperEJTyping and subtyping of Clostridium difficile isolates by using multiple-locus variable-number tandem-repeat analysisJ. Clin. Microbiol.2007451024102810.1128/JCM.02023-06
PubMed Web of Science ®Google Scholar
FranzosaEASequencing and beyond: integrating molecular ‘omics’ for microbial community profilingNat. Rev. Microbiol.20151336037210.1038/nrmicro34514800835
PubMed Web of Science ®Google Scholar
DidelotXMicroevolutionary analysis of Clostridium difficile genomes to investigate transmissionGenome Biol.201213R11810.1186/gb-2012-13-12-r1184056369
PubMed Web of Science ®Google Scholar
HeMEmergence and global spread of epidemic healthcare-associated Clostridium difficileNat. Genet.20134510911310.1038/ng.2478
PubMed Web of Science ®Google Scholar
EyreDWDiverse sources of C. difficile infection identified on whole-genome sequencingN. Engl. J. Med.20133691195120510.1056/NEJMoa1216064
PubMed Web of Science ®Google Scholar
KumarNGenome-based infection tracking reveals dynamics of Clostridium difficile transmission and disease recurrenceClin. Infect. Dis.20166274675210.1093/cid/civ1031
PubMed Web of Science ®Google Scholar
EyreDWComparison of control of Clostridium difficile infection in six english hospitals using whole-genome sequencingClin. Infect. Dis.20176543344110.1093/cid/cix338
PubMed Web of Science ®Google Scholar
FeherCSorianoAMensaJA review of experimental and off-label therapies for Clostridium difficile infectionInfect. Dis. Ther.2017613510.1007/s40121-016-0140-z
PubMed Web of Science ®Google Scholar
KaliACharlesMVSrirangarajSCadazolid: a new hope in the treatment of Clostridium difficile infection Australas. Med. J.2015825326210.4066/AMJ.2015.24414560895
PubMed Web of Science ®Google Scholar
LocherHHIn vitro and in vivo antibacterial evaluation of cadazolid, a new antibiotic for treatment of Clostridium difficile infectionsAntimicrob. Agents Chemother.20145889290010.1128/AAC.01830-133910819
PubMed Web of Science ®Google Scholar
ChiltonCHIn vitro activity of cadazolid against clinically relevant Clostridium difficile isolates and in an in vitro gut model of C. difficile infectionJ. Antimicrob. Chemother.20146969770510.1093/jac/dkt411
PubMed Web of Science ®Google Scholar
GerdingDNSusceptibility of Clostridium difficile isolates from a Phase 2 clinical trial of cadazolid and vancomycin in C. difficile infectionJ. Antimicrob. Chemother.20167121321910.1093/jac/dkv300
PubMed Web of Science ®Google Scholar
Knight-ConnoniVMascioCChesnelLSilvermanJDiscovery and development of surotomycin for the treatment of Clostridium difficileJ. Ind. Microbiol. Biotechnol.20164319520410.1007/s10295-015-1714-6
PubMed Web of Science ®Google Scholar
ChiltonCHEfficacy of surotomycin in an in vitro gut model of Clostridium difficile infectionJ. Antimicrob. Chemother.2014692426243310.1093/jac/dku141
PubMed Web of Science ®Google Scholar
LeeCHSurotomycin versus vancomycin for Clostridium difficile infection: phase 2, randomized, controlled, double-blind, non-inferiority, multicentre trialJ. Antimicrob. Chemother.2016712964297110.1093/jac/dkw246
PubMed Web of Science ®Google Scholar
BoixVPrimary outcomes from a phase 3, randomized, double-blind, active-controlled trial of surotomycin in subjects with Clostridium difficile infectionOpen Forum Infect. Dis.20174ofw27510.1093/ofid/ofw2755414029
PubMed Web of Science ®Google Scholar
LeedsJASachdevaMMullinSDzink-FoxJLamarcheMJMechanism of action of and mechanism of reduced susceptibility to the novel anti-Clostridium difficile compound LFF571Antimicrob. Agents Chemother.2012564463446510.1128/AAC.06354-113421628
PubMed Web of Science ®Google Scholar
SachdevaMLeedsJASubinhibitory concentrations of LFF571 reduce toxin production by Clostridium difficileAntimicrob. Agents Chemother.2015591252125710.1128/AAC.04436-144335859
PubMed Web of Science ®Google Scholar
CitronDMTyrrellKLMerriamCVGoldsteinEJComparative in vitro activities of LFF571 against Clostridium difficile and 630 other intestinal strains of aerobic and anaerobic bacteriaAntimicrob. Agents Chemother.2012562493250310.1128/AAC.06305-113346664
PubMed Web of Science ®Google Scholar
TrzaskoALeedsJAPraestgaardJLamarcheMJMcKenneyDEfficacy of LFF571 in a hamster model of Clostridium difficile infectionAntimicrob. Agents Chemother.2012564459446210.1128/AAC.06355-113421564
PubMed Web of Science ®Google Scholar
TingLSA first-in-human, randomized, double-blind, placebo-controlled, single- and multiple-ascending oral dose study to assess the safety and tolerability of LFF571 in healthy volunteersAntimicrob. Agents Chemother.2012565946595110.1128/AAC.00867-123486596
PubMed Web of Science ®Google Scholar
MullaneKMulticenter, randomized clinical trial to compare the safety and efficacy of LFF571 and vancomycin for Clostridium difficile infectionsAntimicrob. Agents Chemother.2015591435144010.1128/AAC.04251-144325808
PubMed Web of Science ®Google Scholar
BasseresEImpact on toxin production and cell morphology in Clostridium difficile by ridinilazole (SMT19969), a novel treatment for C. difficile infectionJ. Antimicrob. Chemother.2016711245125110.1093/jac/dkv4984830417
PubMed Web of Science ®Google Scholar
VickersRJRidinilazole: a novel therapy for Clostridium difficile infectionInt. J. Antimicrob. Agents20164813714310.1016/j.ijantimicag.2016.04.026
PubMed Web of Science ®Google Scholar
GoldsteinEJCitronDMTyrrellKLComparative in vitro activities of SMT19969, a new antimicrobial agent, against 162 strains from 35 less frequently recovered intestinal Clostridium species: implications for Clostridium difficile recurrenceAntimicrob. Agents Chemother.2014581187119110.1128/AAC.02184-133910813
PubMed Web of Science ®Google Scholar
VickersRJEfficacy and safety of ridinilazole compared with vancomycin for the treatment of Clostridium difficile infection: a phase 2, randomised, double-blind, active-controlled, non-inferiority studyLancet Infect. Dis.20171773574410.1016/S1473-3099(17)30235-95483507
PubMed Web of Science ®Google Scholar
GoldbergEJClostridium difficile infection: a brief update on emerging therapiesAm. J. Health Syst. Pharm.2015721007101210.2146/ajhp140645
PubMed Web of Science ®Google Scholar
OfosuAClostridium difficile infection: a review of current and emerging therapiesAnn. Gastroenterol.20162914715410.20524/aog.2016.00064805733
PubMed Web of Science ®Google Scholar
DieterleMGYoungVBReducing recurrence of C. difficile infectionCell201716937510.1016/j.cell.2017.03.039
PubMed Web of Science ®Google Scholar
BartlettJGBezlotoxumab - a new agent for Clostridium difficile infectionN. Engl. J. Med.201737638138210.1056/NEJMe1614726
PubMed Web of Science ®Google Scholar
Wilcox, M. et al. Bezlotoxumab alone and with actoxumab for prevention of recurrent Clostridium difficile infection in patients on standard of care antibiotics: integrated results of 2 phase 3 studies (MODIFY I and MODIFY II). Open Forum Infect. Dis.2, 67 (2015).
Google Scholar
MathurHReaMCCotterPDRossRPHillCThe potential for emerging therapeutic options for Clostridium difficile infectionGut Microbes2014569671010.4161/19490976.2014.983768
PubMed Web of Science ®Google Scholar
LiubakkaAVaughnBPClostridium difficile infection and fecal microbiota transplantAACN Adv. Crit. Care20162732433710.4037/aacnacc20167035666691
PubMed Web of Science ®Google Scholar
KassamZLeeCHYuanYHuntRHFecal microbiota transplantation for Clostridium difficile infection: systematic review and meta-analysisAm. J. Gastroenterol.201310850050810.1038/ajg.2013.59
PubMed Web of Science ®Google Scholar
YoungsterIOral, capsulized, frozen fecal microbiota transplantation for relapsing Clostridium difficile infectionJAMA20143121772177810.1001/jama.2014.13875
PubMed Web of Science ®Google Scholar
CohenNAA retrospective comparison of fecal microbial transplantation methods for recurrent Clostridium difficile infection Isr. Med. Assoc. J.201618594599
PubMed Web of Science ®Google Scholar
OrensteinRSafety and durability of RBX2660 (microbiota suspension) for recurrent Clostridium difficile infection: results of the PUNCH CD studyClin. Infect. Dis.20166259660210.1093/cid/civ938
PubMed Web of Science ®Google Scholar
MartinJWilcoxMNew and emerging therapies for Clostridium difficile infectionCurr. Opin. Infect. Dis.20162954655410.1097/QCO.0000000000000320
PubMed Web of Science ®Google Scholar
GaoXWMubasherMFangCYReiferCMillerLEDose-response efficacy of a proprietary probiotic formula of Lactobacillus acidophilus CL1285 and Lactobacillus casei LBC80R for antibiotic-associated diarrhea and Clostridium difficile-associated diarrhea prophylaxis in adult patientsAm. J. Gastroenterol.20101051636164110.1038/ajg.2010.11
PubMed Web of Science ®Google Scholar
MaziadePJPereiraPGoldsteinEJA decade of experience in primary prevention of Clostridium difficile infection at a community hospital using the probiotic combination Lactobacillus acidophilus CL1285, Lactobacillus casei LBC80R, and Lactobacillus rhamnosus CLR2 (Bio-K+)Clin. Infect. Dis.201560Suppl. 2S144S14710.1093/cid/civ178
PubMed Web of Science ®Google Scholar
Maziade, P. J., Pereira, P. & Goldstein, E. J. A decade of experience in primary prevention of Clostridium difficileinfection at a community hospital using the probiotic combination Lactobacillus acidophilus CL1285, Lactobacillus casei LBC80R, and Lactobacillus rhamnosus CLR2 (Bio-K+). Clin. Infect. Dis. 60(Suppl. 2), S144–S147 (2015).
Google Scholar
JohnstonBCProbiotics for the prevention of Clostridium difficile-associated diarrhea: a systematic review and meta-analysisAnn. Intern. Med.201215787888810.7326/0003-4819-157-12-201212180-00563
PubMed Web of Science ®Google Scholar
RatsepMA combination of the probiotic and prebiotic product can prevent the germination of Clostridium difficile spores and infectionAnaerobe2017479410310.1016/j.anaerobe.2017.03.019
PubMed Web of Science ®Google Scholar
WulltMHagslattMLOdenholtILactobacillus plantarum 299v for the treatment of recurrent Clostridium difficile-associated diarrhoea: a double-blind, placebo-controlled trialScand. J. Infect. Dis.20033536536710.1080/00365540310010985
PubMed Web of Science ®Google Scholar
PochapinMThe effect of probiotics on Clostridium difficile diarrheaAm. J. Gastroenterol.200095S11S1310.1016/S0002-9270(99)00809-6
PubMed Web of Science ®Google Scholar
AllenSJA high-dose preparation of lactobacilli and bifidobacteria in the prevention of antibiotic-associated and Clostridium difficile diarrhoea in older people admitted to hospital: a multicentre, randomised, double-blind, placebo-controlled, parallel arm trial (PLACIDE)Health Technol. Assess.201317114010.3310/hta17570
Web of Science ®Google Scholar
AllenSJLactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhoea and Clostridium difficile diarrhoea in older inpatients (PLACIDE): a randomised, double-blind, placebo-controlled, multicentre trialLancet20133821249125710.1016/S0140-6736(13)61218-0
PubMed Web of Science ®Google Scholar
VillanoSASeiberlingMTatarowiczWMonnot-ChaseEGerdingDNEvaluation of an oral suspension of VP20621, spores of nontoxigenic Clostridium difficile strain M3, in healthy subjectsAntimicrob. Agents Chemother.2012565224522910.1128/AAC.00913-123457387
PubMed Web of Science ®Google Scholar
NagaroKJNontoxigenic Clostridium difficile protects hamsters against challenge with historic and epidemic strains of toxigenic BI/NAP1/027 C. difficileAntimicrob. Agents Chemother.2013575266527010.1128/AAC.00580-133811292
PubMed Web of Science ®Google Scholar
ZhangKThe non-toxigenic Clostridium difficile CD37 protects mice against infection with a BI/NAP1/027 type of C. difficile strainAnaerobe201536495210.1016/j.anaerobe.2015.09.0094663165
PubMed Web of Science ®Google Scholar
GerdingDNAdministration of spores of nontoxigenic Clostridium difficile strain M3 for prevention of recurrent C. difficile infection: a randomized clinical trialJAMA20153131719172710.1001/jama.2015.3725
PubMed Web of Science ®Google Scholar
IvarssonMELerouxJCCastagnerBInvestigational new treatments for Clostridium difficile infectionDrug Discov. Today20152060260810.1016/j.drudis.2014.12.003
PubMed Web of Science ®Google Scholar
WangQEulerCWDelauneAFischettiVAUsing a novel lysin to help control Clostridium difficile infectionsAntimicrob. Agents Chemother.2015597447745710.1128/AAC.01357-154649177
PubMed Web of Science ®Google Scholar
GiesemannTGuttenbergGAktoriesKHuman alpha-defensins inhibit Clostridium difficile toxin BGastroenterology20081342049205810.1053/j.gastro.2008.03.008
PubMed Web of Science ®Google Scholar
FurciLNew role for human alpha-defensin 5 in the fight against hypervirulent Clostridium difficile strainsInfect. Immun.20158398699510.1128/IAI.02955-144333456
PubMed Web of Science ®Google Scholar
BenderKOA small-molecule antivirulence agent for treating Clostridium difficile infectionSci. Transl. Med.20157306ra14810.1126/scitranslmed.aac9103
PubMed Web of Science ®Google Scholar
JohnsonSVancomycin, metronidazole, or tolevamer for Clostridium difficile infection: results from two multinational, randomized, controlled trialsClin. Infect. Dis.20145934535410.1093/cid/ciu313
PubMed Web of Science ®Google Scholar
RodriguezCTaminiauBVan BroeckJDelmeeMDaubeGClostridium difficile in food and animals: a comprehensive reviewAdv. Exp. Med. Biol.2016932659210.1007/5584_2016_27
PubMed Web of Science ®Google Scholar
GoorhuisAClostridium difficile PCR ribotype 078: an emerging strain in humans and in pigs?J. Clin. Microbiol.200846115710.1128/JCM.01536-072268365
PubMed Web of Science ®Google Scholar
JanezicSInternational Clostridium difficile animal strain collection and large diversity of animal associated strainsBMC Microbiol.20141417310.1186/1471-2180-14-1734100527
PubMed Web of Science ®Google Scholar
Goorhuis, A. et al Clostridium difficile PCR ribotype 078: an emerging strain in humans and in pigs? J. Clin. Microbiol.46, 1157 (2008).
Google Scholar
KnetschCWWhole genome sequencing reveals potential spread of Clostridium difficile between humans and farm animals in the Netherlands, 2002 to 2011Eur. Surveill.2014192095410.2807/1560-7917.ES2014.19.45.20954
PubMedGoogle Scholar
Mc GovernAMHuman Clostridium difficile infection caused by a livestock-associated PCR ribotype 237 strain in Western AustraliaJMM Case Rep.20163e00506210.1099/jmmcr.0.005062
PubMedGoogle Scholar
Knetsch, C. W. et al. Whole genome sequencing reveals potential spread of Clostridium difficile between humans and farm animals in the Netherlands, 2002 to 2011. Eur. Surveill.19, 20954 (2014).
Google Scholar
Mc Govern, A. M. et al. Human Clostridium difficile infection caused by a livestock-associated PCR ribotype 237 strain in Western Australia. JMM Case Rep.3, e005062 (2016).
Google Scholar

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Advances in the diagnosis and treatment of Clostridium difficile infections

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Advances in the diagnosis and treatment of Clostridium difficile infections

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