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Emerging Microbes & Infections Volume 7, 2018 - Issue 1
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Original Articles

Substitution of D701N in the PB2 protein could enhance the viral replication and pathogenicity of Eurasian avian-like H1N1 swine influenza viruses

Suli LiuNational Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and PreventionKey Laboratory for Medical Virology, National Health and Family Planning Commission102206BeijingChina
,
Wenfei ZhuNational Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and PreventionKey Laboratory for Medical Virology, National Health and Family Planning Commission102206BeijingChina
,
Zhaomin FengNational Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and PreventionKey Laboratory for Medical Virology, National Health and Family Planning Commission102206BeijingChina
,
Rongbao GaoNational Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and PreventionKey Laboratory for Medical Virology, National Health and Family Planning Commission102206BeijingChina
,
Junfeng GuoNational Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and PreventionKey Laboratory for Medical Virology, National Health and Family Planning Commission102206BeijingChina
,
Xiyan LiNational Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and PreventionKey Laboratory for Medical Virology, National Health and Family Planning Commission102206BeijingChina
,
Jia LiuNational Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and PreventionKey Laboratory for Medical Virology, National Health and Family Planning Commission102206BeijingChina
,
Dayan WangNational Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and PreventionKey Laboratory for Medical Virology, National Health and Family Planning Commission102206BeijingChinaCorrespondence[email protected]
&
Yuelong ShuNational Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and PreventionKey Laboratory for Medical Virology, National Health and Family Planning Commission102206BeijingChina;School of Public Health (Shenzhen)Sun Yat-sen University510275GuangdongChinaCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0003-2415-6774
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Pages 1-10 | Received 02 Dec 2017, Accepted 21 Mar 2018, Published online: 02 May 2018

References

  • YangHPrevalence, genetics, and transmissibility in ferrets of Eurasian avian-like H1N1 swine influenza virusesProc. Natl Acad. Sci. USA2016113 392 39710.1073/pnas.1522643113
  • PensaertMOttisKVandeputteJKaplanMMBachmannPAEvidence for the natural transmission of influenza A virus from wild ducts to swine and its potential importance for manBull. World Health Organ.19815975782396022
  • de JongJCIsolation of swine-like influenza A(H1N1) viruses from man in Switzerland and The NetherlandsAnn. Inst. Pasteur Virol.198813942943710.1016/S0769-2617(88)80078-9
  • MyersKPOlsenCWGrayGCCases of swine influenza in humans: a review of the literatureClin. Infect. Dis.2007441084108810.1086/5128131973337
  • YangHHuman infection from avian-like influenza A (H1N1) viruses in pigs, ChinaEmerg. Infect. Dis.2012181144114610.3201/eid1807.1200093376805
  • WangDYHuman infection with Eurasian avian-like influenza A(H1N1) virus, ChinaEmerg. Infect. Dis.2013191709171110.3201/eid1910.1304203810748
  • ZuRVirological and serological study of human infection with swine influenza A H1N1 virus in ChinaVirology2013446495510.1016/j.virol.2013.07.022
  • QiXAntigenic and genetic characterization of a European avian-like H1N1 swine influenza virus from a boy in China in 2011Arch. Virol.2013158395310.1007/s00705-012-1423-7
  • ZhuWReassortant Eurasian Avian-Like Influenza A(H1N1) Virus from a Severely Ill Child, Hunan Province, China, 2015Emerg. Infect. Dis.2016221930193610.3201/eid2211.1601815088044
  • LycettSJEstimating reassortment rates in co-circulating Eurasian swine influenza virusesJ. Gen. Virol.2012932326233610.1099/vir.0.044503-03542128
  • CampbellPJResidue 41 of the Eurasian avian-like swine influenza a virus matrix protein modulates virion filament length and efficiency of contact transmissionJ. Virol.2014887569757710.1128/JVI.00119-144054412
  • AlmondJWA single gene determines the host range of influenza virusNature197727061761810.1038/270617a0
  • ScholtissekCMurphyBRHost range mutants of an influenza A virusArch. Virol.19785832333310.1007/BF01317824
  • MurphyBRReassortant virus derived from avian and human influenza A viruses is attenuated and immunogenic in monkeysScience19822181330133210.1126/science.6183749
  • ClementsMLUse of single-gene reassortant viruses to study the role of avian influenza A virus genes in attenuation of wild-type human influenza A virus for squirrel monkeys and adult human volunteersJ. Clin. Microbiol.199230655662265127
  • BrownEGLiuHKitLCBairdSNesrallahMPattern of mutation in the genome of influenza A virus on adaptation to increased virulence in the mouse lung: identification of functional themesProc. Natl Acad. Sci. USA2001986883688810.1073/pnas.11116579834447
  • LiZMolecular basis of replication of duck H5N1 influenza viruses in a mammalian mouse modelJ. Virol.200579120581206410.1128/JVI.79.18.12058-12064.20051212590
  • GabrielGThe viral polymerase mediates adaptation of an avian influenza virus to a mammalian hostProc. Natl Acad. Sci. USA2005102185901859510.1073/pnas.05074151021317936
  • Czudai-MatwichVOtteAMatrosovichMGabrielGKlenkHDPB2 mutations D701N and S714R promote adaptation of an influenza H5N1 virus to a mammalian hostJ. Virol.2014888735874210.1128/JVI.00422-144136279
  • ZhuWDual E627K and D701N mutations in the PB2 protein of A(H7N9) influenza virus increased its virulence in mammalian modelsSci. Rep.2015510.1038/srep141704585756
  • GabrielGHerwigAKlenkHDInteraction of polymerase subunit PB2 and NP with importin alpha1 is a determinant of host range of influenza A virusPLoS Pathog.20084e1110.1371/journal.ppat.00400112222953
  • GabrielGDifferential use of importin-alpha isoforms governs cell tropism and host adaptation of influenza virusNat. Commun.2011210.1038/ncomms11583105303
  • ZhuHNovel reassortment of Eurasian avian-like and pandemic/2009 influenza viruses in swine: infectious potential for humansJ. Virol.201185104321043910.1128/JVI.05352-113187487
  • QiaoCNovel triple reassortant H1N2 influenza viruses bearing six internal genes of the pandemic 2009/H1N1 influenza virus were detected in pigs in ChinaJ. Clin. Virol.20146152953410.1016/j.jcv.2014.10.014
  • KongWTransmission and pathogenicity of novel reassortants derived from Eurasian avian-like and 2009 pandemic H1N1 influenza viruses in mice and guinea pigsSci. Rep.2016610.1038/srep270674890009
  • HudjetzBGabrielGHuman-like PB2 627K influenza virus polymerase activity is regulated by importin-alpha1 and -alpha7PLoS Pathog.20128e100248810.1371/journal.ppat.10024883262014
  • Resa-InfantePImportin-alpha7 is required for enhanced influenza A virus replication in the alveolar epithelium and severe lung damage in miceJ. Virol.2014888166817910.1128/JVI.00270-144097772
  • Resa-InfantePTargeting importin-alpha7 as a therapeutic approach against pandemic influenza virusesJ. Virol.2015899010902010.1128/JVI.00583-154524051
  • BertramSH7N9 influenza A virus exhibits importin-alpha7-mediated replication in the mammalian respiratory tractAm. J. Pathol.201718783184010.1016/j.ajpath.2016.12.017
  • LiuSLZhuWFShuYLStudy of Importin-α7 on the growth properties of influenza viruses using CRISPR/Cas9Chin. J. Virol.201733829835
  • FodorERescue of influenza A virus from recombinant DNAJ. Virol.19997396799682113010
  • KarberG50% end point calculationArch. Exp. Pathol. Pharmakol.193116248048310.1007/BF01863914
  • ReedLJMuenchHA simple method of estimating fifty percent endpointsAm. J. Hyg.193827493497

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