Advanced search
Publication Cover
Emerging Microbes & Infections Volume 7, 2018 - Issue 1
Submit an article Journal homepage
1,920
Views
23
CrossRef citations to date
0
Altmetric
Original Articles

A novel SigB(Q225P) mutation in Staphylococcus aureus retains virulence but promotes biofilm formation

Hui LiuDepartment of Microbiology, College of Basic Medical SciencesThird Military Medical University400038ChongqingChina
,
Weilong ShangDepartment of Microbiology, College of Basic Medical SciencesThird Military Medical University400038ChongqingChina
,
Zhen HuDepartment of Microbiology, College of Basic Medical SciencesThird Military Medical University400038ChongqingChina
,
Ying ZhengDepartment of Microbiology, College of Basic Medical SciencesThird Military Medical University400038ChongqingChina
,
Jizhen YuanDepartment of Microbiology, College of Basic Medical SciencesThird Military Medical University400038ChongqingChina
,
Qiwen HuDepartment of Microbiology, College of Basic Medical SciencesThird Military Medical University400038ChongqingChina
,
Huagang PengDepartment of Microbiology, College of Basic Medical SciencesThird Military Medical University400038ChongqingChina
,
Xinyu CaiDepartment of Emergency, Xinqiao HospitalThird Military Medical University400037 ChongqingChina
,
Li TanDepartment of Microbiology, College of Basic Medical SciencesThird Military Medical University400038ChongqingChina
,
Shu LiDepartment of Microbiology, College of Basic Medical SciencesThird Military Medical University400038ChongqingChina
,
Junmin ZhuDepartment of Microbiology, College of Basic Medical SciencesThird Military Medical University400038ChongqingChina
,
Ming LiDepartment of Microbiology, College of Basic Medical SciencesThird Military Medical University400038ChongqingChina
,
Xiaomei HuDepartment of Microbiology, College of Basic Medical SciencesThird Military Medical University400038ChongqingChina
,
Renjie ZhouDepartment of Emergency, Xinqiao HospitalThird Military Medical University400037 ChongqingChina
,
Xiancai RaoDepartment of Microbiology, College of Basic Medical SciencesThird Military Medical University400038ChongqingChinaCorrespondence[email protected]
&
Yi YangDepartment of Microbiology, College of Basic Medical SciencesThird Military Medical University400038ChongqingChinaCorrespondence[email protected]
 show all
Pages 1-12 | Received 17 Dec 2017, Accepted 19 Mar 2018, Published online: 25 Apr 2018

References

  • DavidMZDaumRSCommunity-associated methicillin-resistant Staphylococcus aureus: epidemiology and clinical consequences of an emerging epidemicClin. Microbiol Rev.201023 616 68710.1128/CMR.00081-092901661
  • ReddyPNSriramaKDirisalaVRAn update on clinical burden, diagnostic tools, and therapeutic options of Staphylococcus aureusInfect. Dis.2017101179916117703999
  • LiuYXuZYangZSunJMaLCharacterization of community-associated Staphylococcus aureus from skin and soft-tissue infections: a multicenter study in ChinaEmerg. Microbes Infect.2016510.1038/emi.2016.1285180372
  • LeeBYThe economic burden of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA)Clin. Microbiol Infect.20131952853610.1111/j.1469-0691.2012.03914.x
  • VenkatesanNPerumalGDobleMBacterial resistance in biofilm-associated bacteriaFuture Microbiol2015101743175010.2217/fmb.15.69
  • BhattacharyaMWozniakDJStoodleyPHall-StoodleyLPrevention and treatment of Staphylococcus aureus biofilmsExpert Rev. Anti Infect. Ther.2015131499151610.1586/14787210.2015.11005335142822
  • OttoMBacterial evasion of antimicrobial peptides by biofilm formationCurr. Top. Microbiol Immunol.2006306251258
  • DonlanRMCostertonJWBiofilms: survival mechanisms of clinically relevant microorganismsClin. Microbiol Rev.20021516719310.1128/CMR.15.2.167-193.2002118068
  • CostertonJWStewartPSGreenbergEPBacterial biofilms: a common cause of persistent infectionsScience19992841318132210.1126/science.284.5418.1318
  • McConougheySJBiofilms in periprosthetic orthopedic infectionsFuture Microbiol.20149987100710.2217/fmb.14.644407677
  • Hall-StoodleyLCostertonJWStoodleyPBacterial biofilms: from the natural environment to infectious diseasesNat. Rev. Microbiol.200429510810.1038/nrmicro821
  • van SchaikWAbeeTThe role of sigmaB in the stress response of Gram-positive bacteria -- targets for food preservation and safetyCurr. Opin. Biotechnol.20051621822410.1016/j.copbio.2005.01.008
  • NicholasROIsolation and characterization of a sigB deletion mutant of Staphylococcus aureusInfect. Immun.19996736673669116562
  • MitchellGSigB is a dominant regulator of virulence in Staphylococcus aureus small-colony variantsPLoS One20138e6501810.1371/journal.pone.00650183660380
  • TuchscherrLLöfflerBStaphylococcus aureus dynamically adapts global regulators and virulence factor expression in the course from acute to chronic infectionCurr. Genet201662151710.1007/s00294-015-0503-0
  • CheungALChienYTBayerASHyperproduction of alpha-hemolysin in a sigB mutant is associated with elevated SarA expression in Staphylococcus aureusInfect. Immun.1999671331133796465
  • ArciolaCRCampocciaDSpezialePMontanaroLCostertonJWBiofilm formation in Staphylococcus implant infections. A review of molecular mechanisms and implications for biofilm-resistant materialsBiomaterials2012335967598210.1016/j.biomaterials.2012.05.031
  • ChenFSmall-molecule targeting of a diapophytoene desaturase inhibits S. aureus virulenceNat. Chem. Biol.20161217417910.1038/nchembio.2003
  • BischoffMMicroarray-based analysis of the Staphylococcus aureus sigmaB regulonJ. Bacteriol.20041864085409910.1128/JB.186.13.4085-4099.2004421609
  • LauderdaleKJBolesBRCheungALHorswillARInterconnections between Sigma B, agr, and proteolytic activity in Staphylococcus aureus biofilm maturationInfect. Immun.2009771623163510.1128/IAI.01036-082663138
  • KiedrowskiMRNuclease modulates biofilm formation in community-associated methicillin-resistant Staphylococcus aureusPLoS One20116e2671410.1371/journal.pone.00267143214024
  • KnoblochJKJägerSHorstkotteMARohdeHMackDRsbU-dependent regulation of Staphylococcus epidermidis biofilm formation is mediated via the alternative sigma factor sigmaB by repression of the negative regulator gene icaRInfect. Immun.2004723838384810.1128/IAI.72.7.3838-3848.2004427440
  • SavageVJChopraIO’NeillAJPopulation diversification in Staphylococcus aureus biofilms may promote dissemination and persistencePLoS ONE20138e6251310.1371/journal.pone.00625133640034
  • RaoQShangWZhouKZhouRRaoXFatal multiple organ failure in an adolescent due to community-acquired methicillin-susceptible Staphylococcus aureus ST121/agrIV lineage: case report and reviewRev. Med Microbiol20152616316710.1097/MRM.0000000000000050
  • LaneWJDarstSAThe structural basis for promoter -35 element recognition by the group IV sigma factorsPLoS Biol.20064e26910.1371/journal.pbio.00402691540707
  • LiuGYStaphylococcus aureus golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activityJ. Exp. Med.200520220921510.1084/jem.200508462213009
  • LiuCIA cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulenceScience20083191391139410.1126/science.11530182747771
  • LeKYOttoMQuorum-sensing regulation in staphylococci-an overviewFront. Microbiol.20156117410.3389/fmicb.2015.011744621875
  • GötzFStaphylococcus and biofilmsMol. Microbiol.2002431367137810.1046/j.1365-2958.2002.02827.x
  • TrotondaMPTamberSMemmiGCheungALMgrA represses biofilm formation in Staphylococcus aureusInfect. Immun.2008765645565410.1128/IAI.00735-082583562
  • O’NeillEHumphreysHO’GaraJPCarriage of both the fnbA and fnbB genes and growth at 37 degrees C promote FnBP-mediated biofilm development in meticillin-resistant Staphylococcus aureus clinical isolatesJ. Med. Microbiol.20095839940210.1099/jmm.0.005504-0
  • OlsonMEStaphylococcus aureus nuclease is an SaeRS-dependent virulence factorInfect. Immun.2013811316132410.1128/IAI.01242-123639593
  • RiceKCThecidA murein hydrolase regulator contributes to DNA release and biofilm development in Staphylococcus aureusProc. Natl Acad. Sci. USA20071048113811810.1073/pnas.06102261041876580
  • Pané-FarréJJonasBFörstnerKEngelmannSHeckerMThe sigmaB regulon in Staphylococcus aureus and its regulationInt. J. Med. Microbiol.200629623725810.1016/j.ijmm.2005.11.011
  • FigueiredoAMSFerreiraFABeltrameCOCôrtesMFThe role of biofilms in persistent infections and factors involved in ica-independent biofilm development and gene regulation in Staphylococcus aureusCrit. Rev. Microbiol.20174360262010.1080/1040841X.2017.1282941
  • HoustonPRoweSEPozziCWatersEMO’GaraJPEssential role for the major autolysin in the fibronectin-binding protein-mediated Staphylococcus aureus biofilm phenotypeInfect. Immun.2011791153116510.1128/IAI.00364-10
  • ListerJLHorswillARStaphylococcus aureus biofilms: recent developments in biofilm dispersalFront. Cell Infect. Microbiol.2014417810.3389/fcimb.2014.001784275032
  • TanXTranscriptome analysis of the biofilm formed by methicillin-susceptible Staphylococcus aureusSci. Rep.2015510.1038/srep119974493712
  • KiedrowskiMRStaphylococcus aureus Nuc2 is a functional, surface-attached extracellular nucleasePLoS ONE20149e9557410.1371/journal.pone.00955743994088
  • PeriasamySHow Staphylococcus aureus biofilms develop their characteristic structureProc. Natl Acad. Sci. USA20121091281128610.1073/pnas.11150061093268330
  • DubracSBonecaIGPoupelOMsadekTNew insights into the WalK/WalR (YycG/YycF) essential signal transduction pathway reveal a major role in controlling cell wall metabolism and biofilm formation in Staphylococcus aureusJ. Bacteriol.20071898257826910.1128/JB.00645-072168699
  • Sharma-KuinkelBKThe Staphylococcus aureus LytSR two-component regulatory system affects biofilm formationJ. Bacteriol.20091914767477510.1128/JB.00348-092715716
  • MashruwalaAAGriesCMScherrTDKielianTBoydJMSaeRS is responsive to cellular respiratory status and regulates fermentative biofilm formation in Staphylococcus aureusInfect. Immun.201785e0015710.1128/IAI.00157-175520442
  • MashruwalaAAGuchteAVBoydJMImpaired respiration elicits SrrAB-dependent programmed cell lysis and biofilm formation in Staphylococcus aureusElife20176e2384510.7554/eLife.238455380435
  • MootzJMRot is a key regulator of Staphylococcus aureus biofilm formationMol. Microbiol20159638840410.1111/mmi.129434467170
  • CrosbyHAThe Staphylococcus aureus global regulator MgrA modulates clumping and virulence by controlling surface protein expressionPLoS Pathog.201612e100560410.1371/journal.ppat.10056044856396
  • SchulthessBThe σB-dependent yabJ-spoVG operon is involved in the regulation of extracellular nuclease, lipase, and protease expression in Staphylococcus aureusJ. Bacteriol.20111934954496210.1128/JB.05362-113165683
  • LanLChengADunmanPMMissiakasDHeCGolden pigment production and virulence gene expression are affected by metabolisms in Staphylococcus aureusJ. Bacteriol.20101923068307710.1128/JB.00928-092901709
  • AndreyDOImpact of the regulators SigB, Rot, SarA and sarS on the toxic shock Tst promoter and TSST-1 expression in Staphylococcus aureusPLoS ONE201510e013557910.1371/journal.pone.01355794537247
  • BabaTBaeTSchneewindOTakeuchiFHiramatsuKGenome sequence of Staphylococcus aureus strain Newman and comparative analysis of staphylococcal genomes: polymorphism and evolution of two major pathogenicity islandsJ. Bacteriol.200819030031010.1128/JB.01000-07
  • PengHWalK(S221P), a naturally occurring mutation, confers vancomycin resistance in VISA strain XN108J. Antimicrob. Chemother.20177210061013
  • DengXExpression of multidrug resistance efflux pump gene norA is iron responsive in Staphylococcus aureusJ. Bacteriol.20121941753176210.1128/JB.06582-113302473

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.