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Original Articles

Overexpression of OqxAB and MacAB efflux pumps contributes to eravacycline resistance and heteroresistance in clinical isolates of Klebsiella pneumoniae

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Pages 1-11 | Received 24 Mar 2018, Accepted 03 Jul 2018, Published online: 01 Aug 2018

References

  • PaczosaMKMecsasJKlebsiella pneumoniae: going on the offense with a strong defenseMicrobiol. Mol. Biol. Rev.201680 629 66110.1128/MMBR.00078-154981674
  • ThadenJTPogueJMKayeKSRole of newer and re-emerging older agents in the treatment of infections caused by carbapenem-resistant EnterobacteriaceaeVirulence2017840341610.1080/21505594.2016.1207834
  • ZhengBMolecular epidemiology and risk factors of carbapenem-resistant Klebsiella pneumoniae infections in Eastern ChinaFront. Microbiol.20178106110.3389/fmicb.2017.010615468447
  • RoySDattaSViswanathanRSinghAKBasuSTigecycline susceptibility in Klebsiella pneumoniae and Escherichia coli causing neonatal septicaemia (2007-10) and role of an efflux pump in tigecycline non-susceptibilityJ. Antimicrob. Chemother.2013681036104210.1093/jac/dks535
  • Rodriguez-AvialCRodriguez-AvialIMerinoPPicazoJJKlebsiella pneumoniae: development of a mixed population of carbapenem and tigecycline resistance during antimicrobial therapy in a kidney transplant patientClin. Microbiol. Infect.201318616610.1111/j.1469-0691.2011.03482.x
  • TsaiHYEmergence of tigecycline-resistant Klebsiella pneumoniae after tigecycline therapy for complicated urinary tract infection caused by carbapenem-resistant Escherichia coliJ. Infect.20126558458610.1016/j.jinf.2012.09.007
  • SpanuTIn vivo emergence of tigecycline resistance in multidrug-resistant Klebsiella pneumoniae and Escherichia coliAntimicrob. Agents Chemother.2012564516451810.1128/AAC.00234-123421558
  • ZhongXFirst emergence of acrAB and oqxAB mediated tigecycline resistance in clinical isolates of Klebsiella pneumoniae pre-dating the use of tigecycline in a Chinese HospitalPLoS ONE20149e11518510.1371/journal.pone.01151854264890
  • LiRLTigecycline susceptibility and molecular resistance mechanisms among clinical Klebsiella pneumoniae strains isolated during non- tigecycline treatmentMicrob. Drug Resist.20172313914610.1089/mdr.2015.0258
  • ShengZKEmergence of tigecycline-and carbapenem-nonsusceptible Klebsiella pneumoniae ST11 clone in patients without exposure to tigecyclineJ. Microbiol. Immunol. Infect.20164996296810.1016/j.jmii.2015.10.014
  • Bialek-DavenetSDifferential contribution of AcrAB and OqxAB efflux pumps to multidrug resistance and virulence in Klebsiella pneumoniaeJ. Antimicrob. Chemother.201570818810.1093/jac/dku340
  • FangLStep-wise increase in tigecycline resistance in Klebsiella pneumoniae associated with mutations in ramR, lon and rpsJPLoS ONE201611e016501910.1371/journal.pone.01650195072711
  • ZhanelGGReview of eravacycline, a novel fluorocycline antibacterial agentDrugs20167656758810.1007/s40265-016-0545-8
  • BassettiMRighiEEravacycline for the treatment of intra-abdominal infectionsExpert. Opin. Investig. Drugs2014231575158410.1517/13543784.2014.965253
  • GrossmanTHTarget-and resistance-based mechanistic studies with TP-434, a novel fluorocycline antibioticAntimicrob. Agents Chemother.2012562559256410.1128/AAC.06187-113346605
  • SutcliffeJAO’BrienWFyfeCGrossmanTHAntibacterial activity of eravacycline (TP-434), a novel fluorocycline, against hospital and community pathogensAntimicrob. Agents Chemother.2013575548555810.1128/AAC.01288-133811277
  • AbdallahMActivity of eravacycline against Enterobacteriaceae and Acinetobacter baumannii, including multidrug-resistant isolates, from New York CityAntimicrob. Agents Chemother.2015591802180510.1128/AAC.04809-144325809
  • NodariCSRibeiroVBBarthALImipenem heteroresistance: high prevalence among Enterobacteriaceae Klebsiella pneumoniae carbapenemase producersJ. Med. Microbiol.20156412412610.1099/jmm.0.081869-0
  • PournarasSCharacteristics of meropenem heteroresistance in Klebsiella pneumoniae carbapenemase (KPC)-producing clinical isolates of K. PneumoniaeJ. Clin. Microbiol.2010482601260410.1128/JCM.02134-092897536
  • MeletisGTzampazESianouETzavarasISofianouDColistin heteroresistance in carbapenemase-producing Klebsiella pneumoniaeJ. Antimicrob. Chemother.20116694694710.1093/jac/dkr007
  • BardetLDeciphering heteroresistance to colistin in a Klebsiella pneumoniae isolate from Marseille, FranceAntimicrob. Agents Chemother.201761e003561710.1128/AAC.00356-175444162
  • BratuSLandmanDGeorgeASalvaniJQualeJCorrelation of the expression of acrB and the regulatory genes marA, soxS and ramA with antimicrobial resistance in clinical isolates of Klebsiella pneumoniae endemic to New York CityJ. Antimicrob. Chemother.20096427828310.1093/jac/dkp1862707265
  • PerezAEffect of transcriptional activators SoxS, RobA, and RamA on expression of multidrug efflux pump AcrAB-TolC in Enterobacter cloacaeAntimicrob. Agents Chemother.2012566256626610.1128/AAC.01085-123497196
  • OlliverAValléMChaslus-DanclaECloeckaertAOverexpression of the multidrug efflux operon acrEF by insertional activation with IS1 or IS10 elements in Salmonella enterica serovar Typhimurium DT204 acrB mutants selected with fluoroquinolonesAntimicrob. Agents Chemother.20054928930110.1128/AAC.49.1.289-301.2005538886
  • ZhangCZUpregulation of AcrEF in quinolone resistance development in Escherichia coli when AcrAB-TolC function is impairedMicrob. Drug Resist.201724182310.1089/mdr.2016.0207
  • KobayashiNNishinoKYamaguchiANovel macrolide-specific ABC-type efflux transporter in Escherichia coliJ. Bacteriol.20011835639564410.1128/JB.183.19.5639-5644.200195455
  • FitzpatrickAWPStructure of the MacAB-TolC ABC-type tripartite multidrug efflux pumpNat. Microbiol.201721707010.1038/nmicrobiol.2017.705447821
  • LinYTIn vivo evolution of tigecycline-non-susceptible Klebsiella pneumonia strains in patients: relationship between virulence and resistanceInt. J. Antimicrob. Agents20164848549110.1016/j.ijantimicag.2016.07.008
  • ChiuSKRoles of ramR and tet(A) mutations in conferring tigecycline resistance in carbapenem-resistant Klebsiella pneumoniae clinical isolatesAntimicrob. Agents Chemother.201761e003911710.1128/AAC.00391-175527587
  • HalabyTGenomic characterization of colistin heteroresistance in Klebsiella pneumoniae during a nosocomial outbreakAntimicrob. Agents Chemother.2016606837684310.1128/AAC.01344-165075093
  • MarchaimDMajor variation in MICs of tigecycline in Gram-negative bacilli as a function of testing methodJ. Clin. Microbiol.2014521617162110.1128/JCM.00001-143993642