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Emerging Microbes & Infections Volume 7, 2018 - Issue 1

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Original Articles

Small molecules targeting coxsackievirus A16 capsid inactivate viral particles and prevent viral binding

Chien-Ju LinSchool of Pharmacy, College of PharmacyKaohsiung Medical University80708KaohsiungTaiwan

Ching-Hsuan LiuGraduate Institute of Medical Sciences, College of MedicineTaipei Medical University11031TaipeiTaiwan;Department of Microbiology and ImmunologyDalhousie UniversityB3H 4R2HalifaxNova ScotiaCanada

Jonathan Y. WangDepartment of Molecular BiosciencesThe University of Texas at Austin78712AustinTXUSA

http://orcid.org/0000-0002-5088-9026

Chun-Ching LinSchool of Pharmacy, College of PharmacyKaohsiung Medical University80708KaohsiungTaiwan;Graduate Institute of Natural Products, College of PharmacyKaohsiung Medical University80708KaohsiungTaiwan

Yi-Fang LiGraduate Institute of Natural Products, College of PharmacyKaohsiung Medical University80708KaohsiungTaiwan

Christopher D. RichardsonDepartment of Microbiology and ImmunologyDalhousie UniversityB3H 4R2HalifaxNova ScotiaCanada;Department of Pediatrics and Canadian Center for VaccinologyIzaak Walton Killam Health CentreB3K 6R8HalifaxNova ScotiaCanada

Liang-Tzung LinGraduate Institute of Medical Sciences, College of MedicineTaipei Medical University11031TaipeiTaiwan;Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University11031TaipeiTaiwanCorrespondence[email protected]

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Pages 1-11 | Received 31 Mar 2018, Accepted 29 Aug 2018, Published online: 26 Sep 2018

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https://doi.org/10.1038/s41426-018-0165-3
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OoiMHWongSCLewthwaitePCardosaMJSolomonTClinical features, diagnosis, and management of enterovirus 71Lancet Neurol.20109 1097 110510.1016/S1474-4422(10)70209-X
PubMed Web of Science ®Google Scholar
HuangWCHuangLMLuCYChengALChangLYAtypical hand-foot-mouth disease in children: a hospital-based prospective cohort studyVirol. J.20131020910.1186/1743-422X-10-209
PubMed Web of Science ®Google Scholar
LaiCCJiangDSWuHMChenHHA dynamic model for the outbreaks of hand, foot, and mouth disease in TaiwanEpidemiol. Infect.201516112
Google Scholar
AngLWEpidemiology and control of hand, foot and mouth disease in Singapore, 2001-2007Ann. Acad. Med.200938106112
PubMed Web of Science ®Google Scholar
MaoQCoxsackievirus A16: epidemiology, diagnosis, and vaccineHum. Vaccin. Immunother.20141036036710.4161/hv.27087
PubMed Web of Science ®Google Scholar
ZhuangZCEpidemiological research on hand, foot, and mouth disease in mainland ChinaViruses201576400641110.3390/v7122947
PubMed Web of Science ®Google Scholar
ChangLYComparison of enterovirus 71 and coxsackie-virus A16 clinical illnesses during the Taiwan enterovirus epidemic, 1998Pediatr. Infect. Dis. J.1999181092109610.1097/00006454-199912000-00013
PubMed Web of Science ®Google Scholar
LegayFFatal coxsackievirus A-16 pneumonitis in adultEmerg. Infect. Dis.2007131084108610.3201/eid1307.070295
PubMed Web of Science ®Google Scholar
WangCYLiLuFWuMHLeeCYHuangLMFatal coxsackievirus A16 infectionPediatr. Infect. Dis. J.20042327527610.1097/01.inf.0000115950.63906.78
PubMed Web of Science ®Google Scholar
RenJStructures of coxsackievirus A16 capsids with native antigenicity: implications for particle expansion, receptor binding, and immunogenicityJ. Virol.201589105001051110.1128/JVI.01102-15
PubMed Web of Science ®Google Scholar
NishimuraYHuman P-selectin glycoprotein ligand-1 is a functional receptor for enterovirus 71Nat. Med.20091579479710.1038/nm.1961
PubMed Web of Science ®Google Scholar
YamayoshiSScavenger receptor B2 is a cellular receptor for enterovirus 71Nat. Med.20091579880110.1038/nm.1992
PubMed Web of Science ®Google Scholar
YamayoshiSHuman SCARB2-dependent infection by coxsackievirus A7, A14, and A16 and enterovirus 71J. Virol.2012865686569610.1128/JVI.00020-12
PubMed Web of Science ®Google Scholar
LinLTHsuWCLinCCAntiviral natural products and herbal medicinesJ. Tradit. Complement. Med.20144243510.4103/2225-4110.124335
PubMedGoogle Scholar
HsuWCLimonium sinense and gallic acid suppress hepatitis C virus infection by blocking early viral entryAntivir. Res.201511813914710.1016/j.antiviral.2015.04.003
PubMed Web of Science ®Google Scholar
CarneiroBMBatistaMNBragaACNogueiraMLRahalPThe green tea molecule EGCG inhibits Zika virus entryVirology201649621521810.1016/j.virol.2016.06.012
PubMed Web of Science ®Google Scholar
ZhangWAntiviral effects of two Ganoderma lucidum triterpenoids against enterovirus 71 infectionBiochem. Biophys. Res. Commun.201444930731210.1016/j.bbrc.2014.05.019
PubMed Web of Science ®Google Scholar
LinLTHydrolyzable tannins (chebulagic acid and punicalagin) target viral glycoprotein-glycosaminoglycan interactions to inhibit herpes simplex virus 1 entry and cell-to-cell spreadJ. Virol.2011854386439810.1128/JVI.01492-10
PubMed Web of Science ®Google Scholar
LinLTBroad-spectrum antiviral activity of chebulagic acid and punicalagin against viruses that use glycosaminoglycans for entryBMC Microbiol.20131318710.1186/1471-2180-13-187
PubMed Web of Science ®Google Scholar
WangSMEnterovirus 71 infection of monocytes with antibody-dependent enhancementClin. Vaccin. Immunol.2010171517152310.1128/CVI.00108-10
PubMed Web of Science ®Google Scholar
ZhangXCoxsackievirus A16 utilizes cell surface heparan sulfate glycosaminoglycans as its attachment receptorEmerg. Microbes Infect.2017610.1038/emi.2017.55
Web of Science ®Google Scholar
Tai, C. J., Li, C. L., Tai, C. J., Wang, C. K. & Lin, L. T. Early viral entry assays for the identification and evaluation of antiviral compounds. J. Vis. Exp., e53124 (2015).
Google Scholar
ShiJHuangXLiuQHuangZIdentification of conserved neutralizing linear epitopes within the VP1 protein of coxsackievirus A16Vaccine2013312130213610.1016/j.vaccine.2013.02.051
PubMed Web of Science ®Google Scholar
DangMMolecular mechanism of SCARB2-mediated attachment and uncoating of EV71Protein Cell2014569270310.1007/s13238-014-0087-3
PubMed Web of Science ®Google Scholar
RenJPicornavirus uncoating intermediate captured in atomic detailNat. Commun.2013410.1038/ncomms2889
Web of Science ®Google Scholar
WangXA sensor-adaptor mechanism for enterovirus uncoating from structures of EV71Nat. Struct. Mol. Biol.20121942442910.1038/nsmb.2255
PubMed Web of Science ®Google Scholar
ZhangGIn vitro and in vivo evaluation of ribavirin and pleconaril antiviral activity against enterovirus 71 infectionArch. Virol.201215766967910.1007/s00705-011-1222-6
PubMed Web of Science ®Google Scholar
AritaMWakitaTShimizuHCharacterization of pharmacologically active compounds that inhibit poliovirus and enterovirus 71 infectivityJ. Gen. Virol.2008892518253010.1099/vir.0.2008/002915-0
PubMed Web of Science ®Google Scholar
ChongPImmunological and biochemical characterization of coxsackie virus A16 viral particlesPLoS One20127e4997310.1371/journal.pone.0049973
PubMed Web of Science ®Google Scholar
ChongPLiuCCChowYHChouAHKleinMReview of enterovirus 71 vaccinesClin. Infect. Dis.20156079780310.1093/cid/ciu852
PubMed Web of Science ®Google Scholar
LiuQA virus-like particle vaccine for coxsackievirus A16 potently elicits neutralizing antibodies that protect mice against lethal challengeVaccine2012306642664810.1016/j.vaccine.2012.08.071
PubMed Web of Science ®Google Scholar
CaiYActive immunization with a coxsackievirus A16 experimental inactivated vaccine induces neutralizing antibodies and protects mice against lethal infectionVaccine2013312215222110.1016/j.vaccine.2013.03.007
PubMed Web of Science ®Google Scholar
LiCWangHShihSRChenTCLiMLThe efficacy of viral capsid inhibitors in human enterovirus infection and associated diseasesCurr. Med. Chem.20071484785610.2174/092986707780363032
PubMed Web of Science ®Google Scholar
De ColibusLStructure elucidation of coxsackievirus A16 in complex with GPP3 informs a systematic review of highly potent capsid binders to enterovirusesPLoS Pathog.201511e100516510.1371/journal.ppat.1005165
PubMed Web of Science ®Google Scholar
De ColibusLMore-powerful virus inhibitors from structure-based analysis of HEV71 capsid-binding moleculesNat. Struct. Mol. Biol.20142128228810.1038/nsmb.2769
PubMed Web of Science ®Google Scholar
KhanbabaeeKvan ReeTTannins: classification and definitionNat. Prod. Rep.20011864164910.1039/b101061l
PubMed Web of Science ®Google Scholar
YoshidaTAmakuraYYoshimuraMStructural features and biological properties of ellagitannins in some plant families of the order MyrtalesInt. J. Mol. Sci.2010117910610.3390/ijms11010079
PubMed Web of Science ®Google Scholar
PourianfarHRKirkKGrolloLInitial evidence on differences among enterovirus 71, coxsackievirus A16 and coxsackievirus B4 in binding to cell surface heparan sulphateVirusdisease20142527728410.1007/s13337-013-0172-x
PubMedGoogle Scholar
TanCWPohCLSamICChanYFEnterovirus 71 uses cell surface heparan sulfate glycosaminoglycan as an attachment receptorJ. Virol.20138761162010.1128/JVI.02226-12
PubMed Web of Science ®Google Scholar
SATTJGSModern Mass Spectrometry. Topics in Current Chemistry2003Schalley CASpringer
Google Scholar
KumarPenmetcha K.R.Systematic screening of viral entry inhibitors using surface plasmon resonanceReviews in Medical Virology2017276e195210.1002/rmv.1952
Web of Science ®Google Scholar
VeluABBPR-3P0128 inhibits RNA-dependent RNA polymerase elongation and VPg uridylylation activities of Enterovirus 71Antivir. Res.2014112182510.1016/j.antiviral.2014.10.003
PubMed Web of Science ®Google Scholar
LinTCChienSCChenHFHsuFLTannins and related compounds from Combretaceae plantsChin. Pharm. J.20005212610.1211/0022357001773616
Google Scholar
LinTCNonakaGNishiokaIHoFCTannins and related compounds. CII. Structures of terchebulin, an ellagitannin having a novel tetraphenylcarboxylic acid (terchebulic acid) moiety, and biogenetically related tannins from Terminalia chebula RetzChem. Pharm. Bull.1990383004300810.1248/cpb.38.3004
Web of Science ®Google Scholar
LinTCStudy on the tannins and related compounds in the fruit of Terminalia catappa LJ. Chin. Med Pharm. Res199214165174
Google Scholar
JuangLJSheuSJChemical identification of the sources of commercial Fructus ChebulaePhytochem. Anal.20051624625110.1002/pca.823
PubMed Web of Science ®Google Scholar
JuangLJSheuSJLinTCDetermination of hydrolyzable tannins in the fruit of Terminalia chebula Retz. by high-performance liquid chromatography and capillary electrophoresisJ. Sep. Sci.20042771872410.1002/jssc.200401741
PubMed Web of Science ®Google Scholar
RenJStructures of coxsackievirus A16 capsids with native antigenicity: implications for particle expansion, receptor binding, and immunogenicityJ. Virol.201589105001051110.1128/JVI.01102-15
PubMed Web of Science ®Google Scholar
PettersenEFUCSF Chimera--a visualization system for exploratory research and analysisJ. Comput. Chem.2004251605161210.1002/jcc.20084
PubMed Web of Science ®Google Scholar
LangPTDOCK 6: combining techniques to model RNA-small molecule complexesRNA2009151219123010.1261/rna.1563609
PubMed Web of Science ®Google Scholar
TrottOOlsonAJAutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreadingJ. Comput. Chem.20103145546119499576
PubMed Web of Science ®Google Scholar

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