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Research Article

Pathologic changes in the retinal pigment epithelium and Bruch’s membrane of fat-fed atherogenic mice

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Pages 8-16 | Published online: 02 Jul 2009

References

  • Hogan MJ. Role of the retinal pigment epithelium in ma-cular disease. Trans Am Acad Ophthalmol Otolaryngol. 1972;76:61–80.
  • Young RW. Pathophysiology of age-related macular degeneration. Surv Ophthalmol. 1987;31:291–306.
  • Liles MR, Newsome DA, Oliver PD. Antioxidant en-zymes in the aging human retinal pigment epithelium. Arch Ophthalmol. 1991;109:1285–1288.
  • Tate DJ Jr, Newsome DA, Oliver PD. Metallothionein shows an age-related decrease in human macular retinal pigment epithelium. Invest Ophthalmol Vis Sci. 1993; 34:2348–2351.
  • Newsome DA, Miceli MV, Tate DJ, Alcock NW, Oliver PD. Zinc content of human retinal pigment epithelium decreases with age and macular degeneration, but super-oxide dismutase increases. Trace Elem Exp Med. 1995;8: 193–199.
  • Blumenkranz MS, Russell SR, Robey MG, Kott-Blumen-kranz R, Penneys N. Risk factors in age-related macul-opathy complicated by choroidal neovascularization. Ophthalmology. 1986;96:552–558.
  • Hirveld H, Luukinen H, Läärä E, Laatikainen, L. Risk factors of age-related maculopathy in a population 70 years of age or older. Ophthalmology. 1996;103: 871–877.
  • Sarks SH. Ageing and degeneration in the macular re-gion: a clinico-pathological study. Brit J Ophthalmol. 1976;60:324–341.
  • Vidaurri JS, Pe'er J, Halfon ST, Halperin G, Zauberman H. Association between drusen and some of the risk factors for coronary artery disease. Ophthalmologica, Basel. 1984;188:243–247.
  • Ishibashi T, Patterson R, Ohnishi Y, Inomata H, Ryan SJ. Formation of drusen in the human eye. Am J Ophthal-mol. 1986;101:342–353.
  • Bressler NM, Silva JC, Bressler SB, Fine SL, Green WR. Clinicopathologic correlation of drusen and retinal pig-ment epithelial abnormalities in age-related macular degeneration. Retina. 1994;14:130–142.
  • Weiter JJ, Delori FC, Wing GL, Fitch KA. Relationship of senile macular degeneration to ocular pigmentation. Am J Ophthalmol. 1985;99:185–187.
  • Sandberg MA, Gaudio AR, Miller S, Weiner A. Iris pig-mentation and extent of disease in patients with neovas-cular age-related macular degeneration. Invest Ophthalmol Vis Sci. 1994;35:2734–2740.
  • Mitchell P, Smith W, Wang JJ. Iris color, skin sun sen-sitivity, and age-related maculopathy: The blue moun-tains eye study. Ophthalmol. 1998;105:1359–1363.
  • Cruickshanks KJ, Klein R, Klein BEK. Sunlight and age-related macular degeneration. The Beaver Dam Eye Study. Arch Ophthalmol. 1993;111:514–518.
  • Klein R, Klein BEK, Linton KLP, DeMets DL. The Beaver Dam Eye Study: The relation of age-related ma-culopathy to smoking. Am J Epidemiol. 1993;137:190–200.
  • Seddon JM, Willett WC, Speizer FE, Hankinson SE. A prospective study of cigarette smoking and age-related macular degeneration in women. JAMA. 1996;276:1141–1146.
  • Christen WG, Glynn RJ, Manson JE, Ajani UA, Buring JE. A prospective study of cigarette smoking and risk of age-related macular degeneration in men. JAMA. 1996; 276:1147–1151.
  • Kahn HA, Leibowitz HM, Ganley JP, Kimi MN, Colton T, Nickerson RS, Dawber TR. The Framingham Eye Study. II: association of ophthalmic pathology with single variables previously measured in the Framingham Heart Study. Am J Epidemiol. 1977;106:33–41.
  • Vingerling JR, Dielemams I, Bots ML, Hofman A, Grob-bee DE, de Jong PT. Age-related macular degeneration is associated with atherosclerosis: The Rotterdam study. Am J Epidemiology. 1996;142: 404–409.
  • Newsome DA, Swartz M, Leone NC, Elston RC, Miller ED. Oral zinc in macular degeneration. Arch Ophthalmol. 1988;106:192–198.
  • Seddon JM, Ajani UA, Sperduto RD, Hiller R, Blair N, Burton TC, Farber MD, Gragoudas ES, Haller J, Miller DT, Yannii77i LA, Willett MD. for the Eye Disease Case-Control Study Group Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degenera-tion. JAMA. 1994;272:1413–1420.
  • Mares-Perlman JA, Brady WE, Klein R, VandenLangen-berg GM, Klein BEK, Palta M. Dietary fat and age-re-lated maculopathy. Arch Ophthalmol. 1995;113:743–748.
  • Mares-Perlman JA, Klein BE, Greger JL, Brady WE, Palta M, Ritter LL. Association of zinc and antioxidant nutri-ents with age-related maculopathy. Arch Ophthalmol 1996;106:192–198.
  • The Eye Disease Case-Control Study Group. Risk fac-tors for neovascular age-related macular degeneration. Arch Ophthalmol. 1992;110:1701–1708.
  • Moss SE, Klein R, Klein BEK, Jensen SC, Meuer, SM. Alcohol consumption and the 5-year incidence of age-related maculopathy. Ophthalmol. 1998;105:789–794.
  • Olin KL, Morse LS, Murphy C, Paul-Murphy J, Line S, Bellhorne RW, Hjelmeland LM, Keen CL. Trace element status and free radical defense in elderly rhesus macaques (Macaca mulatta) with Macular Drusen. Proc Soc Exp Biol Med. 1995;208:370–377.
  • Nicolas MG, Fujiki K, Murayama K, Suzuki MT, Shindo N, Hotta Y, Iwata F, Fujimura T, Yoshikawa Y, Cho F, Kanai A. Studies on the mechanisms of early onset macu-lar degeneration in cynomolgus monkeys. II. Suppres-sion of metallothionein synthesis in the retina in oxida-tive stress. Exp Eye Res. 1996;62:399–408.
  • Paigen BA, Morrow PA, Holmes DM, Williams RA. Quantitative assessment of atherosclerotic lesions in mice. Atherosclerosis. 1987;68:231–240.
  • Paigen B, Morrow A, Brandon C, Michell D, Holmes P. Variation in susceptibility to atherosclerosis among inbred strains of mice. Atherosclerosis. 1985;57:65–73.
  • Sarphie TG, D'Souza NB, VanThiel DH, McClain CT, Deacicu IV. Dose- and time-dependent effects of etha-nol on structural and functional aspects of the liver si-nusoid in the Mouse. Alcoholism: Clin Exp Res. 1997;21: 1128–1136.
  • Sarphie TG, D'Souza NB, Spitzer JJ, Deacicu IV. Chronic ethanol feeding in liquid diet or in drinking water has similar effects on electron microscopic appearances of the hepatic sinusoid in the rat. Alcoholism: Clin Exp Res. 1996;20:973–979.
  • Sarphie TG, D'Souza NB, Deacicu IV. Kupffer cell in-activation prevents lipopolysaccharide-induced structural changes in the rat liver sinusoid: an electron microscope study. Hepatology. 1995;23:788–796.
  • Paigen B, Ishida B, Verstuyft J, Winters RB, Albee D. Atherosclerosis susceptibility differences among progeni-tors of recombinant inbred strains of mice. Arterioscle-rosis. 1990;10:316–323.
  • Wing GL, Blanchard GC, Weiter JJ. The topography and age relationship of lipofuscin concentration in the reti-nal pigment epithelium. Invest Ophthalmol Vis Sci. 1978; 17:601–607.
  • Feeney-Burns L, Berman ER, Rothman H. Lipofuscin of human retinal pigment epithelium. Am J Ophthalmol. 1980;90:783–791.
  • Katz ML, Shanker MJ. Development of lipofuscin-like fluorescence in the retinal pigment epithelium in response to protease inhibitor treatment. Mech Ageing Dev. 1989; 49:23–40.
  • Eldred GE, Lasky MR. Retinal age pigments generated by self-assembling lysosomotropic detergents. Nature. 1993;361:724–726.
  • Fan W, Lin N, Sheedlo HJ, Turner JE. Muller and RPE cell response to photoreceptor cell degeneration in ag-ing Fischer rats. Exp Eye Res. 1996;63:9–18.
  • Mishima H, Hasebe H. Some observations in the fine structure of age changes of the mouse retinal pigment epithelium. Graefe's Arch Clin Exp Ophthalmol. 1978; 209:1–9.
  • Ogata N, Ohkuma H, Kanai K, Nango K, Takada Y, Uyama M. Histological changes in the retinal pigment epithelium and Bruch's membrane in senescence accel-erated mouse. Acta Soc Ophthalmol Jpn. 1992;96:180–189.
  • Organisciak DT, Darrow RM, Noell WK, Blanks JC. Hyperthermia accelerates retinal light damage in rats. Invest Ophthalmol Vis Sci. 1995;36:997–1008.
  • Brunk UT, Dalen H, Roberg K, Hellquist HB. Photo-oxidative disruption of lysosomal membranes causes apoptosis of cultured human fibroblasts. Free Radic Biol Med. 1997;23:616–626.
  • Mishima H, Kondo K. Extrusion of lysosomal bodies from apical mouse retinal pigment epithelium. Graefe's Arch Klin Ophthalmol. 1981;216:209–217.
  • Binger K, Brunk UT. Cellular injury induced by oxi-dative stress is mediated through lysosomal damage. Free Radic Biol Med. 1995;5: 565–574.
  • Newsome DA, Huh W, Green WR. Bruch's membrane age-related changes vary by region. Curr Eye Res. 1987;6: 1211–1221.
  • Green WR, Enger C. Age-related macular degeneration histopathologic studies: The 1992 Lorenz E. Zimmerman Lecture. Ophthalmol. 1992;100:1519–1535.
  • Curcio CA, Millican CL. Basel linear deposit and large drusen are specific for early age-related maculopathy. Arch Ophthalmol. 1999;117:329–339.
  • Killingsworth MC. Angiogenesis in early choroidal neovascularization secondary to age-related macular degeneration. Graefe's Arch Clin Exp Ophthalmol. 1995; 233:313–323.
  • Archer DB, Gardiner TA. Electron microscopic features of experimental choroidal neovascularization. Am J Oph-thalmol. 1981;91:433–457.
  • Katz ML, Robison Jr WG. Evidence of cell loss from the rat retina during senescence. Exp Eye Res. 1996;42: 293–304.
  • Organisciak DT, Winkler BS. Retinal light damage: Prac-tical and theoretical considerations. Prog Retinal Eye Res. 1994;13:1–24.
  • Hafezi F, Marti A, Munz K, Reme CE. Light-induced apoptosis: Differential timing in the retina and pigment epithelium. Exp Eye Res. 1997;64:963–970.

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