79
Views
67
CrossRef citations to date
0
Altmetric
Research Article

Aqueous humor induces transforming growth factor-ß (TGF-ß)-producing regulatory T-cells

, , &
Pages 900-908 | Published online: 02 Jul 2009

References

  • Medawar, P. (1948) Immunity to homologous grafted skin: III. the fate of skin homografts transplanted to the brain to subcutaneous tissue, and to the anterior chamber of the eye. Brit. J. Exp. Path. 29, 58–69.
  • Barker, C. F. and Billingham, R. E. (1977) Immunologi-cally privileged sites. Adv. ImmunoL 25, 1–54.
  • Kaplan, H. J. and Streilein, J. W. (1977) Immune response to immunization via the anterior chamber of the eye: I. Fl lymphocyte-induced-immune deviation. J. ImmunoL 118, 809–814.
  • Streilein, J. W. (1995) Ocular immune privilege in the immunosuppressive intraocular microenvironment. OcuL ImmunoL Inflamm. 3, 139–143.
  • Taylor, A. W. (1994) Immunoregulation of the ocular effector responses by soluble factors in aqueous humor. Reg. ImmunoL 6, 52–57.
  • Kaiser, C., Ksander, B. and Streilein, J. (1989) Inhibition of lymphocyte proliferation by aqueous humor. Reg. ImmunoL 2,42–49.
  • Streilein, J. W., Wilbanks, G. A., Taylor, A. W. and Cousins, S. (1992) Eye-derived cytokines and the immunosuppres-sive intraocular microenvironment: a review. Curr Eye Res. 11 (Suppl.), 41–47.
  • Cousins, S. W., McCabe, M. M., Danielpour, D. and Streilein, J. W. (1991) Identification of transforming growth factor-beta as an immunosuppressive factor in aqueous humor. Invest. Ophthalmol. Vis. Sci. 32, 33–43.
  • Jampel, H. D., Roche, N., Stark, W. J. and Roberts, A. B. (1990) Transforming growth factor-13 in human aqueous humor. Curr Eye Res. 9, 963–969.
  • Granstein, R., Staszewski, R., Knisely, T. L., Zeira, E., Nazareno, R., Latina, M. and Albert, D. M. (1990) Aque-ous humor contains transforming growth factor-I3 and a small (3500 daltons) inhibitor of thymocyte proliferation. I ImmunoL 144, 3021–3026.
  • Taylor, A. W., Streilein, J. W. and Cousins, S. W. (1994) a-Melanocyte-stimulating hormone (a-MSH) suppresses immune-mediated inflammation. Neuroimmunomodula-tion, 1, 188–194.
  • Taylor, A. W., Streilein, J. W. and Cousins, S. W. (1994) Vasoactive intestinal peptide (VIP) contributes to the immunosuppressive activity of normal aqueous humor. I ImmunoL 153, 1080–1086.
  • Geppetti, P., Del Bianco, E., Cecconi, R., Tramontana, M., Romani, A. and Theodorsson, E. (1992) Capsaicin releases calcitonin gene-related peptide from the human iris and ciliary body in vitro. ReguL PepL 41, 83–92.
  • Knisely, T. L., Hosoi, J., Nazareno, R. and Grandstein, R. D. (1994) The presence of biologically significant concentra-tions of glucocorticoids but little or no cortisol binding globulin with aqueous humor: relavance to immune privi-lege in the anterior chamber of the eye. Invest. Ophthal-mol. Vis. Sci. 35, 3711–3723.
  • Knisely, T. L., Bleicher, P. A., Vibbard, C. A. and Granstein, R. D. (1991) Production of latent transforming growth factor-beta and other inhibitory factors by cultured murine iris and ciliary body cells. Curr. Eye Res. 10, 761–771.
  • Uddman, R., Alumets, J., Ehinger, B., Hdkanson, R., Loren, I. and Sundler, F. (1980) Vasoactive intestinal pep-tide nerves in ocular and orbital structures of the cat. Invest. Ophthalmol. Vis. Sci. 19, 878–885.
  • Drager, U. C., Edwards, D. L. and Kleinschmidt, J. (1983) Neurofilaments contain a-melanocyte-stimulating hormone (a-MSH)-like immunoreactivity. Proc. Natl. Acad. Sci. USA, 80, 64086/112.
  • Tinsely, P. W., Fridland, G. H., Killmar, J. T. and Desi-derio, D. M. (1988) Purification, characterization, and localization of neuropeptides in the cornea. Peptides, 9, 1373–1379.
  • Niederkorn, J. Y, Benson, J. L. and Mayhew, E. (1991) Efferent blockade of delayed-type hypersensitivity responses in the anterior chamber of the eye. Reg. ImmunoL 3, 349–354.
  • Apte, R. S. and Niederkorn, J. Y. (1996) Isolation and characterization of a unique natural killer cell inhibitory factor present in the anterior chamber of the eye. J. Immu-nol. 156, 2667–2673.
  • Cousins, S. W., Trattler, W. B. and Streilein, J. W. (1991) Immune privilege and suppression of immunogenic inflammation in the anterior chamber of the eye. Curr Eye Res. 10, 287–297.
  • Taylor, A., Streilein, J. and Cousins, S. (1992) Identifica-tion of alpha-melanocyte-stimulating hormone as a poten-tial immunosuppressive factor in aqueous humor. Curr. Eye Res. 11, 1199–1206.
  • Cherwinski, H. M., Schumacher, J. H., Brown, K. D. and Mosmann, T. R. (1987) Two types of mouse helper cell clones: III. further differences in lymphokine synthesis between Thl and Th2 clones revealed by RNA hybridiza-tion, functionally monospecific bioassays, and monoclonal antibodies. J. Exp. Med. 166, 1229–1244.
  • Cher, D. J. and Mosmann, T. R. (1987) Two types of murine helper T-cell clone: II. delayed-type hypersensitiv-ity is mediated by Thl clones. J. ImmunoL 138, 3688–3694.
  • Fiorentino, D. F., Bond, M. W. and Mosmann, T. R. (1989) Two types of mouse T-helper cell: IV. Th2 clones secrete a factor that inhibits cytokine production by Thl clones. J. Exp. Med. 170, 2081–2095.
  • Chen, Y., Kuchroo, V. K., Inobe, J. I., Hafler, D. A. and Weiner, H. L. (1994) Regulatory T-cell clones induced by oral tolerance: suppression of autoimmune encephalomy-elitis. Science, 265, 1237–1240.
  • Caspi, R., Stiff, L., Morawentz, R., Miller-Rivero, N., Chan, C., Wiggert, B., Nussenblatt, R., Morse, H. and Rizzo, L. (1996) Cytokine-dependent modulation of oral tolerance in a murine model of autoimmune uveitis. Ann. N.Y. Acad. Sci. 778, 315–324.
  • Silver, P., Rizzo, L., Chan, C., Donoso, L., Wiggert, B. and Caspi, R. (1995) Identification of a major pathogenic epitope in the human IRBP molecule recognized by mice of the H-2r haplotype. Invest. Ophthalmol. Vis. Sci. 36, 946–954.
  • Wang, Z. Y, Link, H., Ljungdahl, A., Hojeberg, B., Link, J., He, B., Qiao, J., Me1ms, A. and Olsson, T. (1994) Induction of interferon-gamma, interleukin-4, and transforming growth factor-beta in rats orally tolerized against experi-mental autoimmune myasthenia gravis. Cell. Immun. 157, 353–368.
  • Lawrence, D. A. (1991) Identification and activation of latent transforming growth factor-I3. Methods Enzymol. 198, 327–336.
  • Alard, P., Lantz, 0., Sebagh, M., CaIvo, C. F., Weill, D., Chavanel, G., Senik, A. and Charpentier, B. (1993) A ver-satile ELISA-PCR assay for mRNA quantitation from a few cells. Biothechniques, 15, 730–737.
  • Fargeas, C., Wu, C. Y., Nakajima, T., Cox, D., Nutman, T. and Delespesse, G. (1992) Differential effect of transform-ing growth factor beta on the synthesis of Thl- and Th2-like lymphokines by human T lymphocytes. Eur I Immu-nol. 22, 2173–2176.
  • Fox, F. E., Ford, H. C., Douglas, R., Cherian, S. and Now-ell, P. C. (1993) Evidence that TGF-beta can inhibit human T-lymphocyte proliferation through paracrine and auto-crine mechanisms. Cell. Immun. 150, 45–58.
  • Maeda, H. and Shiraishi, A. (1996) TGF-13 contributes to the shift toward Th2-type responses through direct and IL-10-mediated pathways in tumor-bearing mice. I Immunol. 156, 73–78.
  • Cerwenka, A., Kovar, H., Majdic, 0. and Holier, W. (1996) Fas- and activation-induced apoptosis are reduced in human T-cells preactivated in the presence of TGF-131. Immunol. 156, 459–464.
  • Hoehn, P., Goedert, S., Germann, T., Koelsch, S., Jin, S., Palm, N., Ruede, E. and Schmitt, E. (1995) Opposing effects of TGF-132 on the Thl cell development of naive CD4+ T-cells isolated from different mouse strains. Immunol. 155, 3788–3793.
  • Murry, J. S., Madri, J., Pasqualini, T. and Bottomly, K. (1993) Functional CD4 T-cell subset interplay in an intact immune system. J. Immunol. 150, 4270–4276.
  • Karpus, W. J. and Swanborg, R. H. (1991) CD4+ suppres-sor cells inhibit the function of effector cells of experimen-tal autoimmune encephalomyelitis through a mechanism involving transforming growth factor-I3. J. Immunol. 146, 1163–1168.
  • Miller, A., Lider, 0., Roberts, A. B., Sporn, M. B. and Weiner, H. L. (1992) Suppressor T-cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transform-ing growth factor beta after antigen-specific triggering. Proc. Natl. Acad. Sci. USA, 89, 421–425.
  • Chen, Y. H. and Weiner, H. L. (1996) Dose-dependent acti-vation and deletion of antigen-specific T-cells following oral tolerance. Ann. N.Y Acad. Sci 778, 111–121.
  • Caspi, R. R., Roberge, F. G., Cahn, C. C., Wigget, B., Chader, G. J., Rozenszajn, L. A., Lando, Z. and Nussen-blatt, R. B. (1988) A new model of autoimmune disease; experimental autoimmune uveoretinitis induced in mice with two different retinal antigens. J. Immunol. 140, 1490–1495.
  • Caspi, R. R., Silver, P. B., Chan, C. C., Sun, B., Agarwal, R. K., Wells, J., Oddo, S., Fujino, Y., Najafian, F. and Wilder, R. L. (1996) Genetic susceptibility to experimental autoimmune uveoretinitis in the rat is associated with ele-vated Thl response. J. Immunol. 157, 2668–2675.
  • Gery, I. and Streilein, J. W. (1994) Autoimmunity in the eye and its regulation. Curr. Opinion Immunol. 6, 938–945.
  • Savion, S., Oddo, S., Grover, S. and Caspi, R. R. (1994) Uveitogenic T lymphocytes in the rat: pathogenicity vs. lymphokine production, adhesion molecules and surface antigen expression. I Neuroimmun. 55, 35–44.
  • Butler, T. L. and McMenamin, P. G. (1996) Resident and infiltrating immune cells in the uveal tract in the early and late stages of experimental autoimmune uveoretini-tis. Invest. Ophthalmol. Vis. Sci. 37, 2195–2210.
  • Streilein, J. W. (1996) Peripheral tolerance induction: les-sons from immune-privileged sites and tissues. Transp. Proc. 28, 2066–2070.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.