37
Views
10
CrossRef citations to date
0
Altmetric
Research Article

Intravitreal pharmacokinetics in rabbits of the foscarnet lipid prodrug: 1-O-octadecyl-sn-glycerol-3-phosphonoformate (ODG-PFA)

, , , , , & show all
Pages 161-167 | Published online: 02 Jul 2009

References

  • Gallant, J. E., Moore, R. D., Richman, D. D., Keruly, J., Chaisson, R. E. (1992) Incidence and natural history of cytomegalovirus disease in patients with advanced hu-man immunodeficiency virus disease treated with zidovu-dine. The Zidovudine Epidemiology Study Group. iJ. Infect. Dis.i b166,b 1223–1227.
  • Hoover, D. R., Saah, A. J., Bacellar, H., Phair, J., De-tels, R., Anderson, R., Kaslow, R. A. (1993) Clinical man-ifestations of AIDS in the era of pneumocystis prophy-laxis. Multicenter AIDS Cohort Study. iN. Engl. J. Med.i b329,b 1922–1926.
  • Macdonald, J. M., Torriani, F. J., Morse, L. S., Karavellas,M. P., Reed, J. B., Freeman, W. R. (1998) Lack of re-activation of CMV retinitis after stopping CMV main-tenance therapy in AIDS patients with sustained eleva-tions in CD4 T Cells in Response to Highly Active Antiretroviral Therapy. iJ. Infect. Dis.i b177,b 1182–1187.
  • Palestine, A. G., Polis, M. A., De Smet, M. D., Baird, B. F., Falloon, J., Kovacs, J. A., Davey, R. T., Zurlo, J. J., Zunich, K. M., Davis, M., Hubbard, L., Brother, R., Ferris, F. L., Chew, E., Davis, J. L., Rubin, B. I., Mel-low, S. bD.,b Metcalf, J. A., Manischewitz, J., Minor, J. R., Nussesnblatt, R. B., Masur, H., Lane, H. C. (1991) A randomized, controlled trial of foscarnet in the treat-ment of cytomegalovirus retinitis in patients with AIDS. iAnnals of Internal Medicine,i b115,b 665–673.
  • Studies of Ocular Complications of AIDS Reseach Group. In collaboration with the AIDS Clinical Trials Group. (1992) Mortality in patients with the acquired immuno-deficiency syndrome treated with either foscarnet or ganciclovir for cytomegalovirus retinitis. iN. Engl. J. Med.i b326,b 213–220.
  • Fanning, M. M., Read, S. E., Benson, M., Vas, S., Rachlis, A., Kozousek, V., Mortimer, C., Harvey, P., Schwartz, C., Chew, E. (1990) Foscarnet therapy of cytomegalo-virus retinitis in AIDS. iJournal of Acquired Immune De-ficiency Syndromes,i b3,b 472–479.
  • Holland, G. N., Sidikaro, Y., Kreiger, A. E., Hardy, D., Sakamoto, M. J., Frenkel, L. M., Winston, D. J., Gott-lieb, M. S., Bryson, Y. J., Champlin, R. E., Ho, W. G., Winters, R. E., Wolfe, bP.b bR.,b Cherry, J. bD.b (1987) Treat-ment of cytomegalovirus retinopathy with ganciclovir. iOphthalmology,i b94,b 815–823.
  • Jabs, D. A., Newman, C., De Bustros, S., Polk, B. F. (1987) Treatment of cytomegalovirus retinitis with gan-ciclovir. iOphthalmology,i b94,b 824–830.
  • Studies of Ocular Complications of AIDS Reseach Group. In collaboration with the AIDS Clinical Trials Group. (1997) Parenteral Cidofovir for Cytomegalovirus Retinitis in Patients with AIDS:The HPMPC Peripheral Cytoce- galovirus Retinitis Trial. iAnn. Intern. Med.i b126,b 264–274.
  • Lalezari, J. P., Drew, W. L., Glutzer, E., James, C., Miner, D., Flaherty, J., Fisher, P. E., Cundy, K., Hannigan, J., Martin, J. C., Jaffe, H. S. (1995) (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyThcytosine (cidofovir):results of a Phase I/II study of a novel antiviral nucleotide an-alogue. iJ. Infect. Dis.i b171,b 788–796.
  • Studies of Ocular Complications of AIDS Reseach Group. In collaboration with the AIDS Clinical Trials Group. (1994) Foscarnet-Ganciclovir Cytomegalovirus Retini-tis Trial. 4. Visual outcomes. iOphthalmology,i b101,b 1250–1261 .
  • Henry, K., Cantrill, H., Fletcher, C., Chinnock, B. J., Balfour, H. H. Jr. (1987) Use of intravitreal ganciclovir (dihydroxy propoxymethyl guanine) for cytomegalovi-rus retinitis in a patient with AIDS. iAm. J. Ophthalmol.i b103,b 17–23.
  • Diaz-Llopis, M., Espana, E., Munoz, G., Navea, A., Chipont, E., Cano, J., Menezo, J. L., Romero, F. J. (1994) High dose intravitreal foscarnet in the treatment of cy-tomegalovirus retinitis in AIDS. iBr. J. Ophthalmol.i b78,b 120–124.
  • Yoshizumi, M. 0., Lee, D., Vinci, V., Fajardo, S. (1990) Ocular toxicity of multiple intravitreal DHPG injections. Graefes Archive for Clinical and Experimental Ophthal-imology,i b228,b 350–355.
  • Hitchcock, M. J., Jaffe, H. S., Martin, J. C., Stagg, R. J. (1996) Cidofovir, a new agent with potent anti- herpes-virus activity. iAntiviral Chemistry & Chemotherapy,i b7,b 115–127.
  • Rahhal, F. M., Arevalo, J. F., Munguia, D., Taskintuna, I., Chavez de la Paz, E., Azen, S. bP.,b Freeman, W. R. (1996) Intravitreal cidofovir for the maintenance treat-ment of cytomegalovirus retinitis. iOphthalmology,i b103,b 1078–1083.
  • Taskintuna, I., Rahhal, F. M., Rao, N. A., Wiley, C. A., Mueller, A. J., Banker, A. S., De Clercq, E., Arevalo, J. F., Freeman, W. R. (1997) Adverse events and autopsy findings after intravitreous cidofovir (HPMPC) therapy in patients with acquired immune deficiency syndrome (AIDS). iOphthalmology,i b104,b 1827–1836.
  • Kirsch LS, Arevalo JF, De Clercq E, Chavez de la Paz E, Munguia D, Garcia R, Freeman WR. Phase I/II study of intravitreal cidofovir for the treatment of cytomega-lovirus retinitis in patients with the acquired immuno-deficiency syndrome. iAm. J. Ophthalmol.i 1995;119:466–476.
  • Martin, D. F., Ferris, F. L., Parks, D. J., Walton, R. C., Mellow, S. D., Gibbs, D., Remaley, N. A., Ashton, P., Davis, M. D., Chan, C. C. (1997) Ganciclovir implant exchange. Timing, surgical procedure, and complications. iArch. Ophthalmol.i b115,b 1389–1394.
  • Morley, M. G., Duker, J. S., Ashton, P., Robinson, M. R. (1995) Replacing ganciclovir implants. iOphthalmol-ogy,i b102,b 388–392.
  • Hostetler, K. Y., Kini, G. D., Beadle, J. R., Aldern, K. A., Gardner, M. F., Border, R., Kumar, R., Barshak, L.,Sridhar, C. N., Wheeler, C. J. (1996) Lipid prodrugs of phosphonoacids:greatly enhanced antiviral activity of 1-0-octadecyl-sn-glycero-3-phosphonoformate in HIV-1, HSV-1 and HCMV-infected cells, iin vitro,i iAntiviral Research,i b31,b 59–67.
  • Cheng, L. Y., Hostetler, K. Y., Gardner, M. F., Avila,C. P., Bergeron-Lynn, G., Keefe, K. S., Munguia, D., Garcia, C., Freeman, W. R. (1998) Intravitreal toxicol-ogy of the 1-0-octadecyl-sn-glycerol-3-phosphonofor-mate (ODG-PFA) and its carboxymethyl ester in lipo-some formulation. ARVO Abstract. iInvest. Ophthalmol. Vis. Sci.i b39,b S276.
  • Folch, J., Lees, M., Sloane-Stanley, G. H. (1957) A simple method for the isolation and purification of total lipids from animal tissues. iJ. Biol. Chem.i b226,b 497–509.
  • Shakiba, S., Freeman, W. R., Flores-Aguilar, M., Mun-guia, D., Tatebayashi, M., Besen, G., Amani, R., Wiley,C. A., Vuong, C., Aldern, K. A. (1995) Antiviral effect in human cytomegalovirus-infected cells, pharmacoki-netics, and intravitreal toxicology in rabbits of acyclo-vir diphosphate dimyristoylglycerol. iAntimicrobial Agents and Chemotherapy,i b39,b 1383–1385.
  • Cundy, K. C., Lynch, G., Shaw, J. P., Hitchcock, M. J., Lee, W. A. (1996) Distribution and metabolism of in-travitreal cidofovir and cyclic HPMPC in rabbits. iCur-rent Eye Research,i b15,b 569–576.
  • Kuppermann, B. D., Assil, K. K., Vuong, C., Besen, G., Wiley, C. A., De Clercq, E., Bergeron-Lynn, G., Con-nor, J. D., Pursley, M., Munguia, D., Freeman, W. R. (1996) Liposome-encapsulated (S)-1-(3-hydroxy-2-phos-phonylmethoxypropyl) cytosine for long-acting therapy of viral retinitis. iJ. Infect. Dis.i b173,b 18–23.
  • Besen, G., Chavez-de la Paz, E., Tatebayashi, M., Flores-Aguilar, M., Gangan, P. A., Munguia, D., Wiley, C. A., Jahne, G., Winkler, I., Helsberg, M., Freeman, W. R. (1995) Evaluation of retinal toxicity and efficacy of the anticytomegalovirus compound 2-amino-7-[(1,3-dihy-droxy-2-propoxy) methyl]purine. iAntimicrobial Agents and Chemotherapy,i b39,b 1485–1488.
  • Banker, A. S., De Clercq, E., Taskintuna, I., Keefe, K. S., Bergeron-Lynn, G., Freeman, W. R. (1998) Influence of intravitreal injections of HPMPC and related nucleo-side analogs on intraocular pressure of guinea peg eyes. iInvest. Ophthalmol. Vis. Sci.i b39,b 1233–1242.
  • Smith, I. L., Taskintuna, I., Rahhal, F. M., Powell, H.C., Ai, E., Mueller, A. J., Spector, S. A., Freeman, W. R. (1998) Clinical Failure of CMV Retinitis to Intravit-real Cidofovir is Associated with Antiviral Resistance. iArch. Ophthalmol.i b116,b 178–185.
  • Peyman, G. A., Schulman, J. A., Khoobehi, B., Alkan, H. M., Tawakol, M. E., Mani, H. (1989) Toxicity and clearance of a combination of liposome-encapsulated gan-ciclovir and trifluridine. iRetina,i b9,b 232–236.
  • Peyman, G. A., Khoobehi, B., Tawakol, M., Schulman, J. A., Mortada, H. A., Alkan, H., Fiscella, R. (1987) In-travitreal injection of liposome-encapsulated ganciclo-vir in a rabbit model. iRetina,i b7,b 227–229.
  • Diaz-Llopis, M., Chipont, E., Sanchez, S., Espana, E., Navea, A., Menezo, J. L. (1992) Intravitreal foscarnet for cytomegalovirus retinitis in a patient with acquired immunodeficiency syndrome. iAm. J. Ophthalmol.i b114,b 742–747.
  • Schulman, J., Peyman, G. A., Horton, M. B., Liu, J., Fiscella, R., Pulido, J., Barber, J. C., de Miranda, P. (1986) Intraocular 9-([2-hydroxy-1-(hydroxymethyl) ethoxy] methyl) guanine levels after intravitreal and subconjunc-tival administration. iOphthalmic. Surgery.i b17,b 429–432.
  • Dolnak, D. R., Mungia, D., Wiley, C. A., De Clercq, E., Bergeron-Lynn, G. L., Boscher, C., Connor, J. D., Sher-wood, C., Capparelli, E., Armani, R., Freeman, W. R. (1992) Lack of Retinal Toxicity of HPMPC. iInvest. Oph-thalmol. Vis. Sci.i b33,b 1557–1563.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.