Synthetic bile acid derivatives induce nonapoptotic death of human retinal pigment epithelial cells

Reference

• Martinez JD, Stratagoules ED, LaRue JM, Powell AA, Gause PR, Craven MT, Payne CM, Powell MB, Gerner EW, Earnest DL. Different bile acids exhibit distinct biological effects: The tumor promoter deoxycholic acid induces apoptosis and the chemopreventive agent ursodeoxycholic acid inhibits cell proliferation. Nutr Cancer. 1998;31: 111–118.
   PubMed Web of Science ®Google Scholar
• Heuman DM, Mills AS, McCall J, Hylemon PB, Pandak WM, Vlahcevic ZR. Conjugates of ursodeoxycholate protect against cholestasis and hepatocellular necrosis caused by more hydrophobic bile salts. In vivo studies in the rat. Gastroenterology. 1991;100:203–211.
   PubMed Web of Science ®Google Scholar
• Heuman DM, Bajaj R. Ursodeoxycholate conjugates protect against disruption of cholesterol-rich membranes by bile salts. Gastroenterology. 1994;106:1333–1341.
   Google Scholar
• Rodrigues CMP, Fan G, Ma X, Kren BT, Steer CJ. A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane pertubation. J Clin Invest. 1998;101:2790–2799.
   Google Scholar
• Earnest DL, Holubec H, Wali RK, Jolley CS, Bissonette M, Bhattacharyya AK, Roy H, Khare S, Brasitus TA. Chemo-prevention of azoxymethane-induced colonic carcinogene-sis by supplemental dietary ursodeoxycholic acid. Cancer Res. 1994;54:5071–5074.
   Google Scholar
• Kim DK, Lee JR, Kim A, Lee S, Yoo MA, Kim KW, Kim ND, Suh H. Inhibition of initiation of simian virus 40 DNA replication in vitro by the ursodexocycholic acid and its derivatives. Cancer Lett. 1999;146:147–153.
   Google Scholar
• Hill MJ, Drasar BS, Hawksworth G, Aries V, Crowther JS, Williams RE. Bacteria and aetiology of cancer of large bowel. Lancet. 1971;16:95–100.
   Google Scholar
• Hill MJ, Drasar BS, Williams RE, Meade TW, Cox AG, Simpson JE, Morson BC. Faecal bile-acids and clostridia in patients with cancer of the large bowel. Lancet. 1975; 8:535–539.
   Google Scholar
• Back JH, Kim JA, Kang CM, Lee YS, Kim KW. Induction of apoptosis by bile acids in HepG2 human hepatocellular carcinoma cells. Korean J Physiol Pharmacol. 1997;1: 107–115.
   Google Scholar
• Park YH, Kim JA, Baek JH, Jung EJ, Kim TH, Suh H, Park MH, Kim KW. Induction of apoptosis in HepG2 human hepatocellular carcinoma cells by a novel derivative of ursodeoxycholic acid (UDCA). Arch Pharm Res. 1997; 20:29–33.
   Google Scholar
• Im EO, Lee SE, Suh H, Kim KW, Bae YT, Kim ND. A novel ursodeoxycholic acid derivative induces apoptosis in human MCF-7 breast cancer cells. Pharm Pharmacol Commun. 1999;5:293–298.
   Google Scholar
• Im EO, Choi YH, Paik KJ, Suh H, Jin Y, Kim KW, Yoo YH, Kim ND. Novel bile acid derivatives induce apoptosis via a p53-independent pathway in human breast carcinoma cells. Cancer Lett. (in press).
   Google Scholar
• Machemer R, Laqua H. Pigment epithelium proliferation in retinal detachment (massive periretinal proliferation). Am J Ophthalmol. 1975;80:1–23.
   PubMed Web of Science ®Google Scholar
• Hiscott PS, Grierson I. Subretinal membranes of prolif-erative vitreoretinopathy. Br J Ophthalmol. 1991;75:53–64.
   PubMed Web of Science ®Google Scholar
• Van Horn DL, Aaberg TM, Machemer R. Glial cell pro-liferation in human retinal detachment with massive pre-retinal proliferation. Am J Ophthalmol. 1991;84:383–393.
   Google Scholar
• Khawly JA, Saloupis P, Hatchell DL, Machemer R. Daunorubicin treatment in a refined experimental model of proliferative vitreoretinopathy. Graefe's Arc Clin Exp Oph-thalmol. 1991;229:464–467.
   PubMedGoogle Scholar
• Steinhorst UH, Chen EP, Hatchell DL, Samsa GP, Saloupis PT, Westendorf J, Machemer R. Aclacinomycin A in the treatment of experimental proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci. 1993;34:1753–1760.
   PubMed Web of Science ®Google Scholar
• Yoon HS, Roh SH, Jeong JH, Yoon S, Yoo KS, Yoo YH. Effect of genistein on RPE-J cells: Genistein produces reduction in growth and induces apoptosis. Curr Eye Res. 2000;20:215–224.
   Google Scholar
• Yoon HS, Moon SC, Kim ND, Park BS, Yoo YH. Genis-tein induces apoptosis of RPE-J cells by opening mito-chondrial PTP Biochem Biophys Res Comm. 2000;276: 151–156.
   PubMed Web of Science ®Google Scholar
• Roh SH, Yoon HS, Yoo KW, Park WC, Jeong JH, Yoo YH. Antisense bFGF oligonucleotide reduced adhesion of RPE cells to extracellular matrix molecules and their prolifera-tion. Ophthalmic Res. 2001;31(1):(in press).
   Google Scholar
• Kerr JFR, Wyllie AH, Currie AR. Apoptosis: A basic bio-logical phenomenon with wideranging implications in tissue kinetics. Br J Cancer. 1972;26:239–257.
   Google Scholar
• Wyllie AH, Kerr FFR, Currie AR. Cell death: The signifi-cance of apoptosis. Int Rev Cytol. 1980;68:251–306.
   Google Scholar
• Earnshaw WC, Martins LM, Kaufmann SH. Mammalian caspases: Structure, activation, substrates, and functions during apoptosis. Ann Rev Biochem. 1999;68:383–424.
   Google Scholar
• Kitanaka C, Kuchino Y. Caspase-independent programmed cell death with necrotic morphology. Cell Death Diff. 1999;6:508–515.
   PubMed Web of Science ®Google Scholar
• Martin SJ, Green DR. Apoptosis and cancer: The failure of controls on cell death and cell survival. Crit Rev Oncol Bio Hematol. 1995;18:137–153.
   PubMed Web of Science ®Google Scholar
• Esser P, Bartz-Schmidt KU, Walter P, Kaszli F, Heimann K, Weller M. Apoptotic cell death in proliferative vitreo-retinopathy. Ger J Ophthalmol. 1996;5:73–78.
   Google Scholar
• Kroemer G, Zamzami N, Susin SA. Mitochondrial control of apoptosis. Immunol Today. 1997;18:44–51.
   PubMedGoogle Scholar
• Green DR, Reed JC. Mitochondria and apoptosis. Science. 1998;281:1309–1312.
   PubMed Web of Science ®Google Scholar
• Susin SA, Lorenzo HK, Zamzami N, Marzo I, Snow BE, Brothers GM, Mangion J, Jacotot E, Costantini P, Loeffler M, Larochette N, Goodlett DR, Aebersold R, Siderovski DP, Penninger JIM, Kroemer G. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature. 1999; 397:441–446.
   PubMed Web of Science ®Google Scholar
• Kroemer G, Dallaporta B, Resche-Rigon M. The mito-chondrial death/life regulator in apoptosis and necrosis. Ann Rev Physiol. 1998;60:619–642.
   Google Scholar
• Sparrow JR, Nakanishi K, Parish CA. The lipofuscin fluo-rophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells. Invest Ophthalmol Vis Sci. 2000;41: 1981–1989.
   Google Scholar