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Current Eye Research Volume 26, 2003 - Issue 3-4
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Research Article

An HSV-1 chimeric containing HSV-2 latency associated transcript (LAT) sequences has significantly reduced adrenergic reactivation in the rabbit eye model

James M. Hill LSU Eye Center, New Orleans, LA, USA
,
Amita Patel LSU Eye Center, New Orleans, LA, USA
,
Partha Bhattacharjee LSU Eye Center, New Orleans, LA, USA
&
Philip R. Krause LSU Eye Center, New Orleans, LA, USA
Pages 219-224 | Published online: 02 Jul 2009

References

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  • Hill JM, Sedarati F, Javier RT et al. Herpes simplex virus latent phase transcription facilitates in vivo reactivation. Virology. 1990;174:117–125.
  • Krause PR, Stanberry LR, Bourne N et al. Expression of the herpes simplex virus type 2 latency-associated tran-script enhances spontaneous reactivation of genital herpes in latently infected guinea pigs. J Exp Med. 1995;181:297–306.
  • Yoshikawa T, Hill JM, Stanberry LR et al. The characteris-tic site-specific reactivation phenotypes of HSV-1 and HSV-2 depend upon the latency-associated transcript region. J Exp Med. 1996;184:659–664.
  • Dolan A, Jamieson FE, Cunningham C et al. The genome sequence of herpes simplex virus type 2. J Virol. 199872:2010-2021.
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  • Lekstrom-Himes JA, Pesnicak L, Straus SE. The quantity of latent viral DNA correlates with the relative rates at which herpes simplex virus types 1 and 2 cause recurrent genital herpes outbreaks. J Virol. 1998;72: 2760–2764.
  • Perng GC, Jones C, Ciacci-Zanella J et al. Virus-induced neuronal apoptosis blocked by the herpes simplex virus latency-associated transcript. Science. 2000;287:1500–1503.
  • Thompson RL, Sawtell NM. Herpes simplex virus type 1 latency-associated transcript gene promotes neuronal survival. J Virol. 2001;75:6660–6675.
  • Perng GC, Maguen B, Jin L et al. A gene capable of blocking apoptosis can substitute for the herpes simplex virus type 1 latency-associated transcript gene and restore wild-type reactivation levels. J Virol. 2002;76:1224–1235.
  • Krause PR, Ostrove JM, Straus SE. The nucleotide sequence, 5' end, promoter domain, and kinetics of expres-sion of the gene encoding the herpes simplex virus type 2 latency-associated transcript. J Virol. 1991;65: 5619–5623.

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