The Roche European American Cataract Trial (REACT): A randomized clinical trial to investigate the efficacy of an oral antioxidant micronutrient mixture to slow progression of age-related cataract

References

• Jacques PF, Chylack LT Jr, McGandy RB, Hartz SC. Antioxidant status in persons with and without senile cataract. Arch Ophthalmol. '988;106:337–340.
   Google Scholar
• Jacques PF, Hartz SC, Chylack LT Jr, McGandy RB, Sadowski JA. Nutritional status of persons with and without senile cataract: blood vitamin and mineral levels. Am J Guth Nutr. 1988;48:152–158.
   Google Scholar
• Jacques PF, Chylack LT Jr. Epidemiologic evidence of a role for the antioxidant vitamins and carotenoids in cataract prevention. Am J Guth Nutr. 1991;53 (Suppl): 353S–355S.
   Google Scholar
• Leske MC, Chylack LT Jr, Wu S-Y, the LOCS Study Group. The Lens Opacities Case-Control Study. Risk factors for cataract. Arch Ophthalmol. 1991;109:244–251.
   PubMed Web of Science ®Google Scholar
• Leske MC, Wu S-Y, Hyman L, et al. Biochemical factors in the Lens Opacities Case-Control Study. Arch Ophthalmol. 1995;113:1113–1119.
   Google Scholar
• Robertson JM, Donner AP, Trevethick JR. A possible role for vitamins C and E in cataract prevention. Am J Guth Nutr. 1991;53 (Suppl):3465-35IS.
   Google Scholar
• Hankinson SE, Stampfer MJ, Seddon JM, et al. Nutrient intake and cataract extraction in women: a prospective study. Br Med J. 1992; 305;335–339.
   PubMed Web of Science ®Google Scholar
• Knekt P, Heliovaara M, Rissanen A, Aromaa A, Aaran RK. Serum antioxidant vitamins and risk of cataract. Br Med J. 1992;305:1392–1394.
   Google Scholar
• Sperduto RD, Hu TS, Milton RC, et al. The Linxian cataract studies. Two nutrition intervention trials. Arch Ophthalmol. 1993;III:1246–1253.
   Google Scholar
• Mares-Perlman JA, Brady WE, Klein BEK, et al. Diet and nuclear lens opacities. Am J Epidemiol. 1995;141:322–334.
   PubMed Web of Science ®Google Scholar
• Rouhiainen P, Rouhiainen H, Salonen JT. Association between low plasma vitamin E concentration and progression of early cortical lens opacities. Am J Epidemiol. 1996;144;496–500.
   Google Scholar
• Seddon JM, Christen WG, Manson JE, et al. The use of vitamin supplements and the risk of cataract among US male physicians. Am J Public Health. 1994;84:788–792.
   PubMed Web of Science ®Google Scholar
• Mares-Perlman JA, Lyle BJ, Klein R, et al. Vitamin supplement use and incident cataracts in a population-based study. Arch Ophthalmol. 2000;118:1556–1563.
   Google Scholar
• Chylack LT Jr, Leske MC, McCarthy D, et al. Lens Opacities Classification System II (LOCS II). Arch Ophthalmol. 1989;107:991–997.
   PubMedGoogle Scholar
• Chylack LT Jr, Wolfe JK, Singer DM. The Lens Opacities Classification System, Version III (LOCS III). Arch Ophthalmol. 1993; 111:831–836.
   Google Scholar
• Chylack LT Jr, Wolfe JK, Friend J, et al. Validation of methods for the assessment of cataract progression in the Roche European-American Anticataract Trial (REACT). Ophthalmic Epidemiol. 1995;2:59–75.
   PubMedGoogle Scholar
• Thylefors B, Negrel AD, Pararajasegaram R, Dadzie KY. Global data on blindness. Bull WHO. 1995;73:115–121.
   PubMed Web of Science ®Google Scholar
• World Health Organization. Press Release WHO/27,19 April, 2000. Global Initiative for the Elimination of Avoidable Blindness. (http://www.who.int/inf-pr-2000/en/pr2000-27.html) 19 World Health Organization. Fact Sheet N145, February 1997. Blindness and Visual Disability, Part VI of VII: Socioeconomic Aspects. (http://www.who.int/inf-fs/en/ facti45.html)
   Google Scholar
• Singh AJ, Garner P, Floyd K. Cost-effectiveness of public-funded options for cataract surgery in Mysore, India. Lancet. 2000;355: 180–184.
   Google Scholar
• Fletcher AE, Donoghue M, Devavaram J, et al. Low uptake of eye services in rural India: a challenge for programs of blindness prevention. Arch Ophthalmol. 1999;117: 1393–1399'
   Google Scholar
• Begg C, Cho M, Eastwood S, et al. Improving the quality of reporting of randomized controlled trials. The Consort Statement. J Am Med Assoc. 1996;276:637–639.
   PubMed Web of Science ®Google Scholar
• World Medical Association. Declaration of Helsinki. J Am Med Assoc. 1997;277:925–926.
   PubMed Web of Science ®Google Scholar
• Ferris FL III, Kassoff A, Bresnick GH, Bailey I. New visual acuity charts for clinical research. Am J Ophthalmol. 1982;94:91–96.
   PubMed Web of Science ®Google Scholar
• Ferris FL III, Sperduto RD. Standardized illumination for visual acuity testing in clinical research. Am J Ophthalmol. 1982;94:97–98.
   PubMed Web of Science ®Google Scholar
• Whitaker D, Buckingham T. Oscillatory movement displacement thresholds. Resistance to optical image degradation. Ophthalmol Physiol Opt. 1987;7:121–125.
   PubMed Web of Science ®Google Scholar
• Whitaker D, Elliott D. Towards establishing a clinical displacement threshold technique to evaluate visual function behind cataract. Clin Vis Sci. 1989;4:61–69.
   Google Scholar
• Sparrow JM, Brown NAP, Shun-Shin GA, Bron AJ. The Oxford Modular Cataract Image Analysis System. Eye. 1990;4:638-648. 29 Harris ML, Hanna KJ, Shun-Shin GA, Holden R, Brown NAP. Verification of a new method for the analysis of retroillumination photographs for use in longitudinal studies of cataract. Eye. 1993;7: 572–577.
   Google Scholar
• Hess D, Keller HE, Oberlin R, Bonfani R, Schueep W. Simultaneous determination of retinol, tocopherols, carotenes and lycopene in plasma by means of high-performance liquid chromatography on reversed phase. Int J Vit Nutr Res. 1991;61:232–238.
   Google Scholar
• Schierle J, Haerdi W, Faccin N, Buehler I, Schueep W. Example 8: Geometrical isomers of beta-carotene — a rapid method for quantitative determination. In: Britton G, et al., editors. Carotenoids, Vol IA: Isolation and analysis. Basel: Birkhaeuser Verlag, 1995;265–272.
   Google Scholar
• Vuilleumier JP, Keck EJ. Fluorometric assay of vitamin C in biological materials using a centrifugal analyzer with fluorescence attachment. Micronutr Anal. 1989;5:25–34.
   Google Scholar
• Lian KY, Zeger SL. Longitudinal data analysis using Generalized Linear Models. Biometrika. 1986;73:13–22.
   Web of Science ®Google Scholar
• World Health Organization. Definition of Adverse Events: International Reporting of Adverse Drug Reactions. Final report of the CIOMS working group, 1990.
   Google Scholar
• Wolfe JK, Friend J, Singer DM, Chylack LT Jr. Assessment of the ability of methods of measuring cataract to detect clinically significant change. Ophthalmic Res. 1994;26:55–60.
   Google Scholar
• Chylack LT Jr, Mantell G, Wolfe JK, Friend J, Rosner B, the MSDRL Study Group. Monitoring cataract with LOCS II and counterpart objective measures: Lovastatin and the human lens. 0 ptom Vis ScL 1993;70: 937–943.
   Google Scholar
• Robman LD, McCarty CA, Garrett SK, et al. Comparison of clinical and digital assessment of nuclear optical density. Ophthalmic Res. 1999;31: 119–126.
   PubMed Web of Science ®Google Scholar
• Robman LD, McCarty CA, Garrett SK, et al. Variability in digital assessment of cortical and posterior subcapsular cataract. Ophthalmic Res. 1999;31:110–118.
   PubMed Web of Science ®Google Scholar
• Foo KP, MacLean H. Measured changes in cataract over six months: sensitivity of the Nidek EAS-moo. Ophthalmic Res. 1996;28 (Suppl 2): 32–36.
   PubMed Web of Science ®Google Scholar
• Sparrow JM, Bron AJ, Brown NA, et al. The Oxford Clinical Cataract Classification and Grading System. Mt Ophthalmol. 1986;9:207–225.
   Web of Science ®Google Scholar
• Taylor HR, West SK. A simple system for the clinical grading of lens opacities. Yen Ko Hsueh Pao. 1988;4:14–18.
   Google Scholar
• Sasaki K, Shibata T, Obazawa H, et al. Classification system for cataracts; application by the Japanese Cooperative Cataract Epidemiology Study Group. Ophthalmic Res. 1990;22(Suppl0:46.
   PubMed Web of Science ®Google Scholar
• Klein BEK, Magli YL, Neider MW, Klein R. Wisconsin system for classification of cataracts from photographs. Accession No PB 90-138306. Springfield, VA: National Technical Information Service, 1989.
   Google Scholar
• Thylefors B, Chylack LT Jr, Konuamia K, et al. A simplified cataract grading system — The WHO Cataract Grading Group Geneva: WHO/PBD, 1997.
   Google Scholar
• Leske MC, Chylack LT Jr, Wu S-Y, et al. Incidence and progression of nuclear opacities in the Longitudinal Study of Cataract. Ophthalmology. 1996;103:705–712.
   Google Scholar
• Leske MC, Chylack LT Jr, He Q, et al. Incidence and progression of cortical and posterior subcapsular opacities: The Longitudinal Study of Cataract. Ophthalmology. 1997;104: 1987–1993.
   PubMed Web of Science ®Google Scholar
• Kupfer C. Bowman Lecture. The conquest of cataract; a global challenge. Trans Ophthalmol Soc UK. 1985;104:1—I0.
   Google Scholar
• Hennekens CH, Buring JE, Manson JE, et al. Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. N Engl J Med. 1996;334: 1145–1149.
   PubMed Web of Science ®Google Scholar
• Omenn GS, Goodman GE, Thornquist MD, et al. Effects of a combination of beta-carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med. 1996;334:I150–1155.
   PubMed Web of Science ®Google Scholar
• Heinonen OP and the ca-Tocopherol-13-Carotene Cancer Prevention Study Group. The effect of vitamin E and 13-carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med. 1994;33o:1029–1035.
   Google Scholar
• Mayne ST, Cartmel B, Baum M, et al. Randomized trial of supplemental beta-carotene to prevent second head and neck cancer. Cancer Res. 2001;61:1457–1463.
   PubMed Web of Science ®Google Scholar
• Christen WG, Glynn RJ, Seddon JM, et al. Confirmation of self-reported cataract in the Physicians Health Study. Ophthalmic Epidemiol. 1994; 1:85–91.
   PubMedGoogle Scholar
• Seddon JM, Christen WG, Manson JE, et al. Low-dose aspirin and risks of cataract in a randomized trial of US physicians. Arch Ophthalmol. 1991;109:252–255.
   PubMedGoogle Scholar
• Danielson A, Lorentzon R, Larrson SE. Normal hepatic vitamin-D metabolism in icteric primary biliary cirrhosis associated with pronounced vitamin-D deficiency symptoms. Hepatogastro-enterology. 1982; 29:6–8.
   Google Scholar
• Glynn RJ, Christen WG, Manson JE, et al. Body mass index. An independent predictor of cataract. Arch Ophthalmol. 1995;113: 1131–1137.
   PubMed Web of Science ®Google Scholar
• Schoenfeld ER, Leske MC, Wu S-Y. Recent epidemiologic studies on nutrition and cataract in India, Italy and the United States. J Am Coll Nutr. 1993;12:521–526.
   PubMed Web of Science ®Google Scholar