77
Views
1
CrossRef citations to date
0
Altmetric
Original Scientific Papers

Association between left ventricular strain and cardiac iron load in beta-thalassaemia major: a cardiac magnetic resonance study

ORCID Icon, , , &
Pages 71-80 | Received 10 May 2020, Accepted 03 Feb 2021, Published online: 08 Mar 2021

References

  • Weatherall DJ. The definition and epidemiology of non-transfusion-dependent thalassemia. Blood Rev. 2012;26 (Suppl 1):S3–S6.
  • Vichinsky EP. Changing patterns of thalassemia worldwide. Ann N Y Acad Sci. 2005;1054:18–24.
  • Martin A, Thompson AA. Thalassemias. Pediatr Clin North Am. 2013;60(6):1383–1391.
  • Origa R, Galanello R, Ganz T, et al. Liver iron concentrations and urinary hepcidin in beta-thalassemia. Haematologica. 2007;92(5):583–588.
  • Borgna-Pignatti C, Rugolotto S, De Stefano P, et al. Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine. Haematologica. 2004;89:1187–1193.
  • Anderson LJ, Holden S, Davis B, et al. Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload. Eur Heart J. 2001;22(23):2171–2179.
  • Hahalis G, Kourakli A, Gerasimidou I, et al. Cardiac mortality in {beta}-thalassemia major: resting but not dobutamine stress echocardiography predicts mortality among initially cardiac disease-free patients in a prospective 12-year study. Eur J Heart Fail. 2009;11(12):1178–1181.
  • Nagueh SF, Appleton CP, Gillebert TC, et al. Recommendations for the evaluation of left ventricular diastolic function by echocardiography. Eur J Echocardiogr. 2009;10(2):165–193.
  • Pennell DJ, Udelson JE, Arai AE, et al. Cardiovascular function and treatment in β-thalassemia major: a consensus statement from the American Heart Association. Circulation. 2013;128(3):281–308.
  • Kremastinos DT, Farmakis D. Iron overload cardiomyopathy in clinical practice. Circulation. 2011;124(20):2253–2263.
  • Vogel M, Anderson LJ, Holden S, et al. Tissue Doppler echocardiography in patients with thalassaemia detects early myocardial dysfunction related to myocardial iron overload. Eur Heart J. 2003;24(1):113–119.
  • Bellenger NG, Burgess MI, Ray SG, et al. Comparison of left ventricular ejection fraction and volumes in heart failure by echocardiography, radionuclide ventriculography and cardiovascular magnetic resonance; are they interchangeable? Eur Heart J. 2000;21(16):1387–1396.
  • Giakoumis A, Berdoukas V, Gotsis E, et al. Comparison of echocardiographic (US) volumetry with cardiac magnetic resonance (CMR) imaging in transfusion dependent thalassemia major (TM). Cardiovasc Ultrasound. 2007;5(1):24.
  • Pons-Lladó G, Carreras F, Borrás X, et al. Comparison of morphologic assessment of hypertrophic cardiomyopathy by magnetic resonance versus echocardiographic imaging. Am J Cardiol. 1997;79(12):1651–1656.
  • Pedrizzetti G, Claus P, Kilner PJ, et al. Principles of cardiovascular magnetic resonance feature tracking and echocardiographic speckle tracking for informed clinical use. J Cardiovasc Magn Reson. 2016;18(1):51.
  • Bogarapu S, Puchalski MD, Everitt MD, et al. Novel Cardiac Magnetic Resonance Feature Tracking (CMR-FT) analysis for detection of myocardial fibrosis in pediatric hypertrophic cardiomyopathy. Pediatr Cardiol. 2016;37(4):663–673.
  • Baeßler B, Schaarschmidt F, Dick A, et al. Diagnostic implications of magnetic resonance feature tracking derived myocardial strain parameters in acute myocarditis. Eur J Radiol. 2016;85(1):218–227.
  • Weigand J, Nielsen JC, Sengupta PP, et al. Feature tracking-derived peak systolic strain compared to late gadolinium enhancement in troponin-positive myocarditis: a case-control study. Pediatr Cardiol. 2016;37(4):696–703.
  • Wood JC, Enriquez C, Ghugre N, et al. MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients. Blood. 2005;106(4):1460–1465.
  • Hankins JS, McCarville MB, Loeffler RB, et al. R2* magnetic resonance imaging of the liver in patients with iron overload. Blood. 2009;113(20):4853–4855.
  • Taylor RJ, Moody WE, Umar F, et al. Myocardial strain measurement with feature-tracking cardiovascular magnetic resonance: normal values. Eur Heart J Cardiovasc Imaging. 2015;16(8):871–881.
  • Hinkle DE, Wiersma W, Jurs SG. Applied statistics for the behavioral sciences. 5th ed. Boston (MA): Houghton Mifflin; 2003.
  • Koo TK, Li MY. A guideline of selecting and reporting intraclass correlation coefficients for reliability research. J Chiropr Med. 2016;15(2):155–163.
  • Ari ME, Ekici F, Çetin İİ, et al. Assessment of left ventricular functions and myocardial iron load with tissue Doppler and speckle tracking echocardiography and T2* MRI in patients with β-thalassemia major. Echocardiography. 2017;34(3):383–389.
  • Bilge AK, Altinkaya E, Ozben B, et al. Early detection of left ventricular dysfunction with strain imaging in thalassemia patients. Clin Cardiol. 2010;33(7):E29–E34.
  • Karamanou AG, Hamodraka ES, Vrakas SC, et al. Assessment of left ventricular and atrial diastolic function using two-dimensional (2D) strain imaging in patients with β-thalassemia major. Eur J Haematol. 2014;92(1):59–65.
  • Magrì D, Sciomer S, Fedele F, et al. Early impairment of myocardial function in young patients with beta-thalassemia major. Eur J Haematol. 2008;80(6):515–522.
  • Gupta A, Kapoor A, Phadke S, et al. Use of strain, strain rate, tissue velocity imaging, and endothelial function for early detection of cardiovascular involvement in patients with beta-thalassemia. Ann Pediatr Cardiol. 2017;10(2):158–166.
  • Wood JC, Tyszka JM, Carson S, et al. Myocardial iron loading in transfusion-dependent thalassemia and sickle cell disease. Blood. 2004;103(5):1934–1936.
  • Westwood MA, Anderson LJ, Maceira AM, et al. Normalized left ventricular volumes and function in thalassemia major patients with normal myocardial iron. J Magn Reson Imaging. 2007;25(6):1147–1151.
  • Collins W, Taylor WH. Determination of iron in cardiac and liver tissues by plasma emission spectroscopy. Ann Clin Biochem. 1987;24(5):483–487.
  • Di Odoardo LAF, Giuditta M, Cassinerio E, et al. Myocardial deformation in iron overload cardiomyopathy: speckle tracking imaging in a beta-thalassemia major population. Intern Emerg Med. 2017;12(6):799–809.
  • Carpenter JP, He T, Kirk P, et al. On T2* magnetic resonance and cardiac iron. Circulation. 2011;123(14):1519–1528.
  • Monte I, Buccheri S, Bottari V, et al. Left ventricular rotational dynamics in Beta thalassemia major: a speckle-tracking echocardiographic study. J Am Soc Echocardiogr. 2012;25(10):1083–1090.
  • Cusmà Piccione M, Piraino B, Zito C, et al. Early identification of cardiovascular involvement in patients with β-thalassemia major. Am J Cardiol. 2013;112(8):1246–1251.
  • Garceau P, Nguyen ET, Carasso S, et al. Quantification of myocardial iron deposition by two-dimensional speckle tracking in patients with β-thalassaemia major and Blackfan-Diamond anaemia. Heart. 2011;97(5):388–393.
  • Pizzino F, Meloni A, Terrizzi A, et al. Detection of myocardial iron overload by two-dimensional speckle tracking in patients with beta-thalassaemia major: a combined echocardiographic and T2* segmental CMR study. Int J Cardiovasc Imaging. 2018;34(2):263–271.
  • Chen X, Zhang Z, Zhong J, et al. MRI assessment of excess cardiac iron in thalassemia major: When to initiate? J Magn Reson Imaging. 2015;42(3):737–745.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.