Anthracycline-induced cardiotoxicity in women without cardiovascular diseases: molecular and genetic predictors

References

• European Commission. ECIS - European Cancer Information System 2019. Available online at: https://ecis.jrc.ec.europa.eu/.
   Google Scholar
• Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA Cancer J Clin. 2016;66(1):7–30.
   PubMed Web of Science ®Google Scholar
• Zamorano JL, Lancellotti P, Rodriguez Munoz D, ESC Scientific Document Group, et al. 2016 ESC position paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC committee for practice guidelines:  The Task Force for cancer treatments and cardiovascular toxicity of the European Society of Cardiology (ESC)). Eur Heart J. 2016;37(36):2768–2801.
   PubMed Web of Science ®Google Scholar
• Curigliano G, Cardinale D, Dent S, et al. Cardiotoxicity of anticancer treatments: epidemiology, detection, and management. CA Cancer J Clin. 2016;66(4):309–325.
   PubMed Web of Science ®Google Scholar
• Bloom MW, Hamo CE, Cardinale D, et al. Cancer therapy-related cardiac dysfunction and heart failure: part 1: definitions, pathophysiology, risk factors, and imaging. Circ Heart Fail. 2016;9(1):e002661
   PubMed Web of Science ®Google Scholar
• Murabito A, Hirsch E, Ghigo A. Mechanisms of anthracycline-induced cardiotoxicity: is mitochondrial dysfunction the answer? Front Cardiovasc Med. 2020; 7:12–35.
   PubMed Web of Science ®Google Scholar
• Bodley A, Liu LF, Israel M, et al. DNA topoisomerase II-mediated interaction of doxorubicin and daunorubicin congeners with DNA. Cancer Res. 1989;49(21):5969–5978.
   PubMed Web of Science ®Google Scholar
• Capranico G, Tinelli S, Austin CA, et al. Different patterns of gene expression of topoisomerase II isoforms in differentiated tissues during murine development. Biochim Biophys Acta. 1992;1132(1):43–48.
   PubMed Web of Science ®Google Scholar
• Lyu YL, Lin CP, Azarova AM, et al. Role of topoisomerase IIbeta in the expression of developmentally regulated genes. Mol Cell Biol. 2006;26(21):7929–7941.
   PubMed Web of Science ®Google Scholar
• Plana JC, Galderisi M, Barac A, et al. Expert consensus for multimodality imaging evaluation of adult patients during and after cancer therapy: a report from the American society of echocardiography and the European association of cardiovascular imaging. J Am Soc Echocardiogr. 2014;27(9):911–939.
   PubMed Web of Science ®Google Scholar
• Silva dos Santos D, dos Santos Goldenberg RC. Doxorubicin-Induced Cardiotoxicity: From Mechanisms to Development of Efficient Therapy. 2018. 10.5772/intechopen.79588.
   Google Scholar
• Octavia Y, Tocchetti CG, Gabrielson KL, et al. Doxorubicin-induced cardiomyopathy: from molecular mechanisms to therapeutic strategies. J Mol Cell Cardiol. 2012;52(6):1213–1225.
   PubMed Web of Science ®Google Scholar
• Raj S, Franco SI, Lipshultz SE. Anthracycline-induced cardiotoxicity: a review of pathophysiology, diagnosis, and treatment. Curr Treat Options Cardiovasc Med. 2014;16(6):315.
   PubMedGoogle Scholar
• Salazar-Mendiguchía J, González-Costello J, Roca J, et al. Anthracycline-mediated cardiomyopathy: Basic molecular knowledge for the cardiologist. Arch Cardiol Mex. 2014;84(3):218–223.
   PubMedGoogle Scholar
• Ghigo A, Li M, Hirsch E. New signal transduction paradigms in anthracycline-induced cardiotoxicity. Biochim Biophys Acta. 2016;1863(7 Pt B):1916–1925.
   PubMed Web of Science ®Google Scholar
• Grakova EV, Shilov SN, Kopeva KV, et al. Anthracycline-Induced cardiotoxicity: the role of endothelial dysfunction. Cardiology. 2021;146(3):315–323. Published online: February 17, <SE-START > DOI:</SE-START > .
   PubMed Web of Science ®Google Scholar
• Lien Y-C, Lin S-M, Nithipongvanitch R, et al. TNF receptor deficiency exacerbated adriamycin-induced cardiomyocte apoptosis: an insight into the fas connection. Mol Cancer Ther. 2006;5(2):261–269.
   PubMed Web of Science ®Google Scholar
• Kalivendi SV, Konorev EA, Cunningham S, Vanamala SK, et al. Doxorubicin activates nuclear factor of activated T-lymphocytes and fas ligand transcription: role of mitochondrial reactive oxygen species and calcium. Biochem J. 2005;389(Pt 2):527–539. Jul 15;
   PubMed Web of Science ®Google Scholar
• Wang S, Kotamraju S, Konorev E, et al. Activation of nuclear factor-kappaB during doxorubicin-induced apoptosis in endothelial cells and myocytes is pro-apoptotic: the role of hydrogen peroxide. Biochem J. 2002;367(Pt 3):729–740.
   PubMed Web of Science ®Google Scholar
• Nozaki N, Shishido T, Takeishi Y, et al. Modulation of doxorubicin-induced cardiac dysfunction in toll-like receptor-2-knockout mice. Circulation. 2004;110(18):2869–2874.
   PubMed Web of Science ®Google Scholar
• Romano S, Fratini S, Ricevuto E, et al. Serial measurements of NT-proBNP are predictive of not-high-dose anthracycline cardiotoxicity in breast cancer patients. Br J Cancer. 2011;105(11):1663–1668.
   PubMed Web of Science ®Google Scholar
• Lu X, Zhao Y, Chen C, et al. BNP as a marker for early prediction of anthracycline-induced cardiotoxicity in patients with breast cancer. Oncol Lett. 2019;18(5):4992–5001.
   PubMed Web of Science ®Google Scholar
• Kittiwarawut A, Vorasettakarnkij Y, Tanasanvimon S, et al. Serum NT-proBNP in the early detection of doxorubicin-induced cardiac dysfunction. Asia-Pacific journal of clinical oncology. Asia-Pac J Clin Oncol. 2013;9(2):155–161. doi: 10.1111/j.1743-7563.2012.01588.x.
   PubMed Web of Science ®Google Scholar
• Shulgin KK, Popova TN, Rakhmanova TI. Isolation and purification of glutathione peroxidase. Appl Biochem Microbiol. 2008; 44(3):247–250. PMID: 18663949
   Web of Science ®Google Scholar
• Zheikova TV, Golubenko MV, Buikin S, et al. Glutathione peroxidase 1 (GPX1) single nucleotide polymorphism Pro198→leu: Association with life span and coronary artery disease. Mol Biol. 2012;46(3):433–437. doi: 10.1134/S0026893312030144
   Web of Science ®Google Scholar
• Shuvalova YA, Kaminnyi AI, Meshkov AN, et al. Pro198Leu polymorphism of GPx-1 gene and activity of erythrocytic glutathione peroxidase and lipid peroxidation products. Bull Exp Biol Med. 2010; 149(6):743–745.
   PubMed Web of Science ®Google Scholar
• Hamanishi T, Furuta H, Kato H, et al. Functional variants in the glutathione peroxidase-1 (GPx-1) gene are associated with increased intima-media thickness of carotid arteries and risk of macrovascular diseases in Japanese type 2 diabetic patients. Diabetes. 2004;53(9):2455–2460.
   PubMed Web of Science ®Google Scholar
• Zhao GL, Li QJ, Lu HY. Association between NOS3 genetic variants and coronary artery disease in the han population. Genet Mol Res. 2016;15(2):1–4.
   Web of Science ®Google Scholar
• Neilan TG, Blake SL, Ichinose F, et al. Disruption of nitric oxide synthase 3 protects against the cardiac injury, dysfunction, and mortality induced by doxorubicin. Circulation. 2007;116(5):506–514.
   PubMed Web of Science ®Google Scholar
• Krajinovic M, Elbared J, Drouin S, et al. Polymorphisms of ABCC5 and NOS3 genes influence doxorubicin cardiotoxicity in survivors of childhood acute lymphoblastic leukemia. Pharmacogenomics J. 2016;16(6):530–535.
   PubMed Web of Science ®Google Scholar
• Aminkeng F, Ross CJD, Rassekh SR, CPNDS Clinical Practice Recommendations Group, et al. Recommendations for genetic testing to reduce the incidence of anthracycline-induced cardiotoxicity. Br J Clin Pharmacol. 2016;82(3):683–695.
   PubMed Web of Science ®Google Scholar
• Wyche KE, Wang SS, Griendling KK, et al. C242T CYBA polymorphism of NADPH oxidase is associated with reduced respiratory burst in human neutrophils. Hypertension. 2004;43(6):1246–1251. 960:
   PubMed Web of Science ®Google Scholar
• Moreno MU, Jose GS, Fortuno A, et al. The C242T CYBA polymorphism of NADPH oxidase is associated with essential hypertension. J Hypertens. 2006; 24(7):1299–1306.
   PubMed Web of Science ®Google Scholar
• Reichwagen A, Ziepert M, Kreuz M, et al. Association of NADPH oxidase polymorphisms with anthracycline-induced cardiotoxicity in the RICOVER-60 trial of patients with aggressive CD20(+) B-cell lymphoma. Pharmacogenomics. 2015;16(4):361–372.
   PubMed Web of Science ®Google Scholar
• Cascales A, Pastor-Quirante F, Sánchez-Vega B, et al. Association of anthracycline-related cardiac histological lesions with NADPH oxidase functional polymorphisms. Oncologist. 2013;18(4):446–453.
   PubMed Web of Science ®Google Scholar
• Uo T, Kinoshita Y, Morrison RS. Apoptotic actions of p53 require transcriptional activation of PUMA and do not involve a direct mitochondrial/cytoplasmic site of action in postnatal cortical neurons. J Neurosci. 2007;27(45):12198–12210.
   PubMed Web of Science ®Google Scholar
• Skala M, Hanouskova B, Skalova L, et al. MicroRNAs in the diagnosis and prevention of drug-induced cardiotoxicity. Arch Toxicol. 2019; 93(1):1–9.
   PubMed Web of Science ®Google Scholar