77
Views
2
CrossRef citations to date
0
Altmetric
Original Scientific Papers

DR1-CSE/H2S pathway upregulates autophagy and inhibits H9C2 cells damage induced by high glucose

ORCID Icon, , , , , , , & show all
Pages 594-606 | Received 03 Jan 2022, Accepted 26 Aug 2022, Published online: 05 Oct 2022

References

  • Dos Santos JM, Tewari S, Mendes RH. The role of oxidative stress in the development of diabetes mellitus and its complications. J Diabetes Res. 2018;2018:4189813.
  • Jia G, Hill MA, Sowers JR. Diabetic cardiomyopathy: an update of mechanisms contributing to this clinical entity. Circ Res. 2018;122(4):624–638.
  • Tong M, Saito T, Zhai P, et al. Mitophagy is essential for maintaining cardiac function during high fat diet-induced diabetic cardiomyopathy. Circ Res. 2019;124(9):1360–1371.
  • Yang F, Qin Y, Wang Y, et al. Metformin inhibits the NLRP3 inflammasome via AMPK/mTOR-dependent effects in diabetic cardiomyopathy. Int J Biol Sci. 2019;15(5):1010–1019.
  • Yu L, Chen Y, Tooze SA. Autophagy pathway: Cellular and molecular mechanisms. Autophagy. 2018;14(2):207–215.
  • Yim WW, Mizushima N. Lysosome biology in autophagy. Cell Discov. vol2020;6:6.
  • Kuo CJ, Hansen M, Troemel E. Autophagy and innate immunity: Insights from invertebrate model organisms. Autophagy. 2018;14(2):233–242.
  • Poillet-Perez L, White E. Role of tumor and host autophagy in cancer metabolism. Genes Dev. 2019;33(11-12):610–619.
  • Wu D, Wang H, Teng T, et al. Hydrogen sulfide and autophagy: a double edged sword. Pharmacol Res. 2018;131:120–127.
  • Wang H, Liu Y, Wang D, et al. The upstream pathway of mTOR-mediated autophagy in liver diseases. Cells. 2019;8(12):1597.
  • Wang H, Zhong P, Sun L. Exogenous hydrogen sulfide mitigates NLRP3 inflammasome-mediated inflammation through promoting autophagy via the AMPK-mTOR pathway. Biol Open. 2019;8:043653.
  • Ma J, Du D, Liu J, et al. Hydrogen sulphide promotes osteoclastogenesis by inhibiting autophagy through the PI3K/AKT/mTOR pathway. J Drug Target. 2020;28(2):176–185.
  • Corsello T, Komaravelli N, Casola A. Role of hydrogen sulfide in NRF2- and sirtuin-dependent maintenance of cellular redox balance. Antioxidants. 2018;7(10):129.
  • Cao X, Ding L, Xie ZZ, et al. A review of hydrogen sulfide synthesis, metabolism, and measurement: is modulation of hydrogen sulfide a novel therapeutic for cancer? Antioxid Redox Signal. 2019;31(1):1–38.
  • Ellmers LJ, Templeton EM, Pilbrow AP, et al. Hydrogen sulfide treatment improves post-infarct remodeling and long-term cardiac function in CSE knockout and wild-type mice. IJMS. 2020;21(12):4284.
  • Wu D, Hu Q, Zhu D. An update on hydrogen sulfide and nitric oxide interactions in the cardiovascular system. Oxid Med Cell Longev. 2018;2018:4579140.
  • Masi A, Ascenzi P. H2S: a ‘double face’ molecule in health and disease. Biofactors. 2013;39(2):186–196.
  • Huang H, Han Y, Wang X, et al. Inhibitory effect of the D(3) dopamine receptor on insulin receptor expression and function in vascular smooth muscle cells. Am J Hypertens. 2011;24(6):654–660.
  • Missale C, Nash SR, Robinson SW, et al. Dopamine receptors: from structure to function. Physiol Rev. 1998;78(1):189–225.
  • Li HZ, Han LP, Jiang CM, et al. Effect of dopamine receptor 1 on apoptosis of cultured neonatal rat cardiomyocytes in simulated ischaemia/reperfusion. Basic Clin Pharmacol Toxicol. 2008;102(3):329–336.
  • Éva Sikura K, Combi Z, Potor L, et al. Hydrogen sulfide inhibits aortic valve calcification in heart via regulating RUNX2 by NF-κB, a link between inflammation and mineralization. J Adv Res. 2021;27:165–176.
  • Xiao T, Luo J, Wu Z, et al. Effects of hydrogen sulfide on myocardial fibrosis and PI3K/AKT1-regulated autophagy in diabetic rats. Mol Med Rep. 2016;13(2):1765–1773.
  • Li L, Li M, Li Y, et al. Exogenous H2S contributes to recovery of ischemic post-conditioning-induced cardioprotection by decrease of ROS level via down-regulation of NF-κB and JAK2-STAT3 pathways in the aging cardiomyocytes. Cell Biosci. 2016;6:26.
  • Li H, Mani S, Cao W, et al. Interaction of hydrogen sulfide and estrogen on the proliferation of vascular smooth muscle cells. PLoS One. 2012;7(8):e41614.
  • Yang F, Zhang L, Gao Z, et al. Exogenous H2S protects against diabetic cardiomyopathy by activating autophagy via the AMPK/mTOR pathway. Cell Physiol Biochem. 2017;43(3):1168–1187.
  • Wang W, Ge T, Chen X, et al. Advances in the protective mechanism of NO, H2S, and H2 in myocardial ischemic injury. Front Cardiovasc Med. 2020;7:588206.
  • Liang B, Xiao T, Long J, et al. Hydrogen sulfide alleviates myocardial fibrosis in mice with alcoholic cardiomyopathy by downregulating autophagy. Int J Mol Med. 2017;40(6):1781–1791.
  • Talaei F, Bouma HR, Van der Graaf AC, et al. Serotonin and dopamine protect from hypothermia/rewarming damage through the CBS/H2S pathway. PLoS One. 2011;6(7):e22568.
  • Wen X, Xi Y, Zhang Y, et al. DR1 activation promotes vascular smooth muscle cell apoptosis via up-regulation of CSE/H2S pathway in diabetic mice. FASEB J. 2022;36:e22070.
  • Li H, Wu R, Xi Y, et al. Dopamine 1 receptors inhibit apoptosis via activating CSE/H2S pathway in high glucose-induced vascular endothelial cells. Cell Biol Int. 2022;46(7):1098–1108.
  • Chang G, Bai S, Sun F, et al. SKF38393 prevents high glucose (HG)-induced endothelial dysfunction by inhibiting the effects of HG on cystathionine γ-lyase/hydrogen sulfide activity and via a RhoA/ROCK1 pathway. Front Biosci. 2022;27:49.
  • Li H, Sun F, Bai S, et al. The DR1-CSE/H2S system inhibits renal fibrosis by downregulating the ERK1/2 signaling pathway in diabetic mice. Int J Mol Med. 2021;49(1):7.
  • Tummers B, Green DR. Caspase-8: regulating life and death. Immunol Rev. 2017;277(1):76–89.
  • Iurlaro R, Muñoz-Pinedo C. Cell death induced by endoplasmic reticulum stress. FEBS J. 2016;283(14):2640–2652.
  • Kalpage HA, Bazylianska V, Recanati MA, et al. Tissue-specific regulation of cytochrome c by post-translational modifications: respiration, the mitochondrial membrane potential, ROS, and apoptosis. FASEB J. 2019;33(2):1540–1553.
  • Lee YJ, Lee C. Porcine deltacoronavirus induces caspase-dependent apoptosis through activation of the cytochrome c-mediated intrinsic mitochondrial pathway. Virus Res. 2018;253:112–123.
  • Warren CFA, Wong-Brown MW, Bowden NA. BCL-2 family isoforms in apoptosis and cancer. Cell Death Dis. 2019;10(3):177.
  • Levine B, Kroemer G. Biological functions of autophagy genes: a disease perspective. Cell. 2019;176(1-2):11–42.
  • Ichimiya T, Yamakawa T, Hirano T, et al. Autophagy and autophagy-related diseases: a review. IJMS. 2020;21(23):8974.
  • Xiao Y, Wu QQ, Duan MX, et al. TAX1BP1 overexpression attenuates cardiac dysfunction and remodeling in STZ-induced diabetic cardiomyopathy in mice by regulating autophagy. Biochim Biophys Acta Mol Basis Dis. 2018;1864(5 Pt A):1728–1743.
  • Luo J, Yan D, Li S, et al. Allopurinol reduces oxidative stress and activates Nrf2/P62 to attenuate diabetic cardiomyopathy in rats. J Cell Mol Med. 2020;24(2):1760–1773.
  • Runwal G, Stamatakou E, Siddiqi FH, et al. LC3-positive structures are prominent in autophagy-deficient cells. Sci Rep. 2019;9(1):10147.
  • Jeong SJ, Zhang X, Rodriguez-Velez A, et al. P62/SQSTM1 and selective autophagy in cardiometabolic diseases. Antioxid Redox Signal. 2019;31(6):458–471.
  • Sun Y, Yao X, Zhang QJ, et al. Beclin-1-dependent autophagy protects the heart during sepsis. Circulation. 2018;138(20):2247–2262.
  • Herzig S, Shaw RJ. AMPK: guardian of metabolism and mitochondrial homeostasis. Nat Rev Mol Cell Biol. 2018;19(2):121–135.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.