N-Acetyl cysteine and clomiphene citrate for induction of ovulation in polycystic ovary syndrome: a cross-over trial

References

• Kovacs G, Wood C. The current status of polycystic ovary syndrome. Aust N Z J Obstet Gynecol 2001; 41(1)65–8
   PubMed Web of Science ®Google Scholar
• Guzick D. Polycystic ovary syndrome. Symptomatology, pathophysiology and epidemiology. Am J Obstet Gynecol 1998; 179: 89–93
   Web of Science ®Google Scholar
• Slowey MJ. Polycystic ovary syndrome: new perspective on an old problem. South Med J 2001; 94(2)190–5
   PubMed Web of Science ®Google Scholar
• Speroff L, Glass RH, Kase NG. Clinical Gynecologic Endocrinology and Infertility6th edn. Lippincott, Williams & Wilkins, Baltimore 1999; 488–521
   Google Scholar
• Daly DC, Walters CA, Soto-Albors CE. Randomized study of dexamethason in ovulation induction with clomiphene citrate. Fertil Steril 1984; 41: 844–8
   PubMed Web of Science ®Google Scholar
• American College of Obstetricians & Gynecologists Practice bulletin. Management of infertility caused by ovulatory dysfunction. Int J Gynecol Obstet 2002; 77: 177–88
   PubMedGoogle Scholar
• Parcile A, Gallardo E, Venegas E. Normo-prolactinemic anovulation unresponsive to clomiphene citrate: ovulation induction with bromocriptine. Fertil Steril 1990; 53: 50–5
   PubMed Web of Science ®Google Scholar
• Zacur HA, Foster GV, Andersen AG, Als-Nielsen B, Hornnes PJ. Hyperprolactinemia and time interval from human chorionic gonadotrophin (hCG) injection to follicular rupture. Human Reprod 1992; 10: 3202–5
   Google Scholar
• Branigan ME, Ester A. Using oral contraceptive as a treatment for clomid-resistant patients. Fertil Steril 1999; 71: 544–6
   PubMed Web of Science ®Google Scholar
• Barbieri RL. Induction of ovulation in infertile women with hyperandrogenism and insulin resistance. Am J Obstet Gynecol 2000; 183: 1412–8
   PubMed Web of Science ®Google Scholar
• Vandermolen DT, Ratts VS, Evans DW, Kauma SW, Nestler JE. Metformin increases the ovulatory rate and pregnancy rate from clomphene citrate in patients with polycystic ovary syndrome who are resistant to clomiphene citrate alone. Fertil Steril 2001; 75(2)310–5
   PubMed Web of Science ®Google Scholar
• Bedaiwy MA, Rizk A, A Inany H, Falcone T. N-Acetylcysteine improves pregnancy rates in long standing unexplained infertility: a novel mechanism of ovulation induction. Fertil Steril 2004; 82(Suppl)S228
   PubMed Web of Science ®Google Scholar
• Rizk A, Bedaiwy M, Al-Inany H. N-Acetyl cysteine is a novel adjuvant to clomiphene citrate in clomiphene citrate resistant patients with polycystic ovary syndrome. Fertil Steril 2005; 83: 367–70
   PubMed Web of Science ®Google Scholar
• Issels RD, Nagele A, Eckert KG, Wilmanns W. Promotion of cystine uptake and its utilization for glutathione biosynthesis induced by cysteamine and N-acetylcysteine. Biochem Pharmacol 1988; 37: 881–8
   PubMed Web of Science ®Google Scholar
• De Vries N, De Flora S. N acetyl-1-cysteine. J Cell Biochem 1993; suppl 17F: 270–7
   Google Scholar
• Nakata K, Kawase M, Ogino S. Effects of age on level of cysteine, glutathione and related enzyme activities in livers of mice and rats and an attempt to replenish hepatic glutathione level of mouse with cysteine derivatives. Mech Ageing Dev 1996; 90: 195–207
   PubMed Web of Science ®Google Scholar
• Hoffer E, Baum Y, Tabak A, Taitelman U. N-acetylcysteine increases the glutathione content and protects rat alveolar type II cells against paraquat-induced cytotoxicity. Toxicol Lett 1996; 84: 7–12
   PubMed Web of Science ®Google Scholar
• De Mattia G, Bravi MC, Laurenti O, Cassone-Faldettta M, Projetti A, De Luca O. Reduction of oxidative stress by oral N-acetyl cysteine treatment decreases plasma soluble vascular cell adhesion molecule-1 concentrations in non-obese, non-dyslipidemic, normotensive patients with non-insulin dependent diabetes. Diabetologia 1998; 41: 1392–6
   PubMed Web of Science ®Google Scholar
• Arstall MA, Yang J, Stafford I. N-acetylcysteine in combination with nitroglycerine and streptokinase for the treatment of evolving acute myocardial infarction. Safety and biochemical effects. Circulation 1995; 92: 2855–62
   PubMed Web of Science ®Google Scholar
• Bostom AG, Shemin D, Yoburn D. Lack of effect of oral N-acetylcysteine on the acute dialysis-related lowering of total plasma homocysteine in hemodialysis patients. Atherosclerosis 1996; 120: 241–4
   PubMed Web of Science ®Google Scholar
• Gogu SR, Agrawal KC. The protective role of zinc and N-acetylcysteine in modulating ziduvodine induced hematopoietic toxicity. Life Sci 1996; 59: 1323–9
   PubMed Web of Science ®Google Scholar
• Chung FL, Kellof G, Steele V. Chemopreventive efficacy of arylalkyl isothiocyanates and n-acetylcysteine for lung tumorigenesis in Fischer rats. Cancer Res 1996; 67: 842–8
   Google Scholar
• Omara FO, Balkely BR, Bernier J, Fournier M. Immunomodulatory and protective effects of N-acetylcysteine in mitogen-activated murine splenocytes in vitro. Toxicology 1997; 116: 219–26
   PubMed Web of Science ®Google Scholar
• Herzenberg LA, De Rosa SC, Dubs JG. Glutathione deficiency is associated with impaired survival in HIV disease. Proc Natl Acad Sci U S A 1997; 94: 1967–72
   PubMed Web of Science ®Google Scholar
• Kobrinsky NL, Hartfield D, Horner H. Treatment of advanced malignancies with high-dose acetaminophen and N-acetylcysteine rescue. Cancer Invest 1996; 14: 202–10
   PubMed Web of Science ®Google Scholar
• Hultberg B, Andersson A, Isaksson A. The effects of homocysteine and copper ions on the concentration and redox status of thiols in cell line cultures. Clin Chim Acta 1997; 262: 39–51
   PubMed Web of Science ®Google Scholar
• Borgström L, Kagedal B, Paulson O. Pharmacokinetics of N acetyl cysteine in man. Eur J Clin Pharmacol 1986; 31: 217–22
   PubMed Web of Science ®Google Scholar
• Weidmann P, de Courten M, Bohlen L. Insulin resistance, hyperinsulinemia and hypertension. J Hypertens Suppl 1993; 11(Suppl 5)S27–38
   PubMedGoogle Scholar
• Pieper GM, Siebeneich W. Oral administration of the antioxidant N-acetyl cysteine, abrogates diabetes-induced endothelial dysfunction. J Cardiovasc Pharmacol 1998; 32: 101–5
   PubMed Web of Science ®Google Scholar
• Fulghesu AM, Ciampelli M, Muzj G, Belosi C, Selvaggi L, Ayala GF. N-acetyl cysteine treatment improves insulin sensitivity in women with polycystic ovary syndrome. Fertil Steril 2002; 77: 1128–35
   PubMed Web of Science ®Google Scholar
• Odetti P, Pesce C, Traverso N, Menini S, Mianeri EP, Cosso L. Comparative trial of N-acetyl cysteine, taurine and oxerutin on skin and kidney damage in long term experimental diabetes. Diabetes 2003; 52: 499–505
   PubMed Web of Science ®Google Scholar
• Sekhon B, Sekhon C, Khan M, Patel SJ, Singh I, Singh AK. N acetyl cysteine protects against injury in a rat model of focal cerebral ischaemia. Brain Res 2003; 971: 1–8
   PubMed Web of Science ®Google Scholar
• Lappas M, Permezel M, Rice GE. N-acetyl cysteine inhibits phospholipids metabolism, proinflammatory cytokine release, protease activity, and nuclear factor-kappaB deoxyribonucleic acid-binding activity in human fetal membrane in vitro. J Clin Endocrinol Metab 2003; 88: 1723–9
   PubMed Web of Science ®Google Scholar
• The Rotterdam ESHRE/ASRM-sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 2004; 81(1)19–25
   Web of Science ®Google Scholar
• Adams J, Polson DW, Franks S. Prevalence of polycystic ovaries in women with anovulation and idiopathic hirsutism. BMJ Clin Res Ed 1986; 293: 355–9
   PubMed Web of Science ®Google Scholar
• Hanson RL, Prately RE, Bogardus C, Narayan KM, Roumain JM, Pettit DJ, et al. Evaluation of simple indices of insulin sensitivity and insulin secretion for use in epidemiologic studies. Am J Epidemiol 2000; 151: 190–8
   PubMed Web of Science ®Google Scholar
• Mather KJ, Hunt AE, Steinberg HO, Paradisi G, Hok G, Katz A, et al. Repeatability characteristics of simple indices of insulin resistance: implications for research applications. J Clin Endocrinol Metab 2001; 86: 5457–64
   PubMed Web of Science ®Google Scholar
• Wentzel P, Thunberg L, Eriksson UJ. Teratogenic effect of diabetic serum is prevented by supplementation of superoxide dismutase and N-acetyl cysteine in rat embryo culture. Diabetologia 1997; 40: 7–14
   PubMed Web of Science ®Google Scholar
• Kelly GS. Clinical applications of N-acetyl cysteine. Alternative Med Rev 1998; 3(2)114–27
   PubMedGoogle Scholar
• Wong M, Wells PG. Effects of N-acetylcysteine on fetal development and on phenytoin teratogenicity in mice. Teratog Carcinog Mutagen 1988; 8: 65–79
   PubMedGoogle Scholar
• Threlkeld DS ( ed) Drug Facts and Comparisons. St Louis, MO: Facts and Comparisons, 1997: 1090–4.
   Google Scholar