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Research Article

Cytokine network and dysregulated apoptosis in atopic dermatitis

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Pages 178-182 | Published online: 02 Jul 2009

References

  • Akdis CA, Akdis M, Trautmann A, Blaser K. Immune regulation in atopic dermatitis. Curr Opin Immunol 2000;12:641–6.
  • Akdis M, Simon H-U, Weigl L, Kreyden 0, Blaser K, Akdis CA. Skin homing (cutaneous lymphocyte-associated antigen-positive) CD8+ T cells respond to superantigen and contribute to eosinophilia and IgE production in atopic dermatitis. J Immunol 1999;163: 466–75.
  • Akdis CA, Akdis M, Simon D, Dibbert B, Weber M, Gratzl S, et al. T cells and T-cell-derived cytokines as pathogenic factors in the nonallergic form of atopic dermatitis. J Invest Dermatol 1999;113:628–34.
  • Akdis M, Akdis CA, Weigl L, Disch R, Blaser K. Skin-homing, CLA+ memory T cells are activated in atopic dermatitis and regulate IgE by an IL-13-dominated cytokine pattern. IgGI counter-regulation by CLA- memory T cells. J Immunol 1997; 159:4611–9.
  • Varney VA, Hamid QA, Gaga M, Ying S, Jacobson M, Frew AJ, et al. Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses. J Clin Invest 1993;92: 644–51.
  • Abernathy-Carver KJ, Sampson HA, Picker LJ, Leung DYM. Milk-induced eczema is associated with the expansion of T cells expressing cutaneous lymphocyte antigen. J Clin Invest 1995; 95:913–8.
  • Denkers EY, Caspar P, Sher A. Toxoplasma gondii possesses a superantigen activity that selectively expands murine T cell receptor V 13 5-bearing CD8+ lymphocytes. J Exp Med 1994; 180:985–94.
  • Chou MC, Lee SC, Lin YS, Lei HY. V 13 8+ CD4- CD8-subpopulation induced by staphylococcal enterotoxin B. Immu-nol Let 1997;55:85–91.
  • Leyden JE, Marpies RR, Kligman AM. Staphylococcus aureus in the lesions of atopic dermatitis. Br J Dermatol 1974;90:525–30.
  • Leung DYM, Gately M, Trumble A, Ferguson-Darnell B, Schlievert PM, Picker U. Bacterial superantigens induce T cell expression of the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen, via stimulation of interleukin 12 production. J Exp Med 1995;181: 747–53.
  • Grewe M, Bruijnzeel-Koomen CAFM, Schöpf E, Thepen T, Langeveld-Wildschut AG, Ruzicka T, et al. A role for Thl and Th2 cells in the immunopathogenesis of atopic dermatitis. Immunol Today 1998;19:359–61.
  • Grewe M, Czech W, Morita A, Werfel T, Klammer M, Kapp A, et al. Human eosinophils produce biologically active IL-12: implications for control of T cell responses. J Immunol 1998; 161:415–20.
  • Kang K, Kubin M, Cooper KD, Lessin SR, Trinchieri G, Rook AH. IL-12 synthesis by human Langerhans cells. J Immunol 1996;156:1402–7.
  • Muller G, Saloga J, Germann T, Bellinghausen I, Mohamadza-deh M, Knop J, et al. Identification and induction of human keratinocyte-derived IL-12.J Clin Invest 1994;94: 1799–805.
  • Stoll S, Jonuleit H, Schmitt E, Muller G, Yamauchi H, Kurimoto M, et al. Production of functional IL-18 by different subtypes of murine and human dendritic cells (DC) DC-derived IL-18 enhances IL-12-dependent Thl development Eur J Immunol 1998;28: 3231–9.
  • Kehry MR, Yamashita LC. Low-affmity IgE receptor (CD23) function on mouse B cells: role in IgE-dependent antigen focusing. Proc Natl Acad Sci USA 1989;86:7556–60.
  • van Neerven RJJ, Wikborg T, Lund G, Jacobsen B, Brinch-Nielsen A, Arnved J, et al. Blocking antibodies induced by specific allergy vaccination prevent the activation of CD4+ T cells by inhibiting serum IgE-facilitated allergen presentation. J Immunol 1999;163: 2944–52.
  • Santamaria LF, Bheekha R, Van Reijsen FC, Perez Soler MT, Suter M, Bruijnzeel-Koomen CAFM, et al. Antigen focusing by specific monomeric immunoglobulin E bound to CD23 on Epstein-Barr virus-transformed B cells. Human Immunol 1993; 37:23–30.
  • Schmitt DA, Bieber T, Cazenave JP, Hanau D. Fc receptors of human Langerhans cells. J Invest Dermatol 1990;94:15–21.
  • Achatz G, Nitschke L, Lamers MC. Effect of transmembrane and cytoplasmic domains of IgE on the IgE response. Science 1977;276:409–11.
  • Fahy JV, Fleming HE, Wong HH, Liu JT, Su JQ Reinmann J, et al. The effect of an anti-IgE monoclonal antibody on the early-and late-phase responses to allergen inhalation in asthmatic subjects. Am J Respir Grit Care Med 1997;155:1828–33.
  • Coyle AJ, Wagner K, Bertrand C, Tsuyuki S, Bews J, Heusser C. Central role of immunoglobulin-E in the induction of lung eosinophil infiltration and T helper 2 cell cytokine production: inhibition by a non-anaphylactogenic anti-IgE antibody. J Exp Med 1996;183:1303–8.
  • Heusser C, Jardieu P. Therapeutic potential of anti-IgE anti-bodies. Curr Opin Immunol 1997;9:805–14.
  • Spergel JM, Mizoguchi E, Oettgen H, Bhan AK, Geha RS. Roles of Thl and Th2 cytokines in a murine model of allergic dermatitis. J Chin Invest 1999;103: 1103–11.
  • Hanifm JM, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venerol 1980;92:44–7.
  • Wathrich B. Serum IgE in atopic dermatitis. Clin Allergy 1978; 8:241–8.
  • Hamid Q Boguniewicz M, Leung DYM. Differential in situ cytokine gene expression in acute versus chronic atopic derma-titis. J Chin Invest 1994;94:870–6.
  • Picker LJ, Michie SA, Rott LS, Butcher EC. A unique phenotype of skin associated lymphocytes in humans: preferential expression of the HECA-452 epitope by benign and malignant T-cells at cutaneous sites. Am J Pathol 1990;136:1053–61.
  • Picker LJ, Kishimoto TK, Smith CW, Warnock RA, Butcher EC. ELAM-1 is an adhesion molecule for skin homing T cells. Nature 1991;349: 796–9.
  • Santamaria Babi LF, Moser R, Perez Soler MT, Picker LJ, Blaser K, Hauser C. The migration of skin- homing T cells across cytokine-activated human endothelial cell layers involves inter-action of the cutaneous lymphocyte-associated antigen (CLA), the very late antigen-4 (VLA-4) and the lymphocyte function-associated antigen-1 (LFA-1). J Immunol 1995;154:1543–50.
  • Santamaria Babi LF, Picker LJ, Perez Soler MT, Drzimalla K, Bohr P, Blaser K, et al. Circulating allergen-reactive T cells from patients with atopic dermatitis and allergic contact dermatitis express the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen. J Exp Med 1995;181:1935–40.
  • Fuhlbrigge RC, Kieffer JD, Armerding D, Kupper TS. Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin homing T cells. Nature 1997;389:978–81.
  • Akdis M, Klunker S, Schliz M, Blaser K, Akdis CA. Expression of cutaneous lymphocyte-associated antigen on human CD4+ and CD8+ Th2 cells. Eur J Immunol 2000;30: 3533–41.
  • Wagers AJ, Waters CM, Stoolman LM, Kansas GS. Interleukin 12 and interleukin 4 control T cell adhesion to endothelial selectins through opposite effects on ai,3-fucosyltransferase VII gene expression. J Exp Med 1998;188:2225–31.
  • Grewe J, Gyufko K, Schöpf K, Krutmann J. Lesional expression of interferon-7 in atopic eczema. Lancet 1994;343: 25–6.
  • Hamid Q Naseer T, Minshall EM, Song YL, Boguniewicz M, Leung DYM. In vivo expression of IL-12 and IL-13 in atopic dermatitis. J Allergy Clin Immunol i996;98:225-3i.
  • Morales J, Homey B, Vicari AP, Hudak S, Oldham E, Hedrick J, et al. CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells. Proc Natl Acad Sci USA 1999;96:14470–5.
  • Homey B, Wang W, Soto H, Buchanan ME, Wiesenborn A, Catron D, et al. The orphan chemokine receptor G protein-coupled receptor-2 (CRP-2,CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC). J Immunol 2000;164: 3465–70.
  • Vestergaard C, Yoneyama H, Murai M, Nakamura K, Tamaki K, Terashima Y, et al. Overproduction of Th2-specific chemo kines in NC/Nga mice exhibiting atopic dermatitis-like lesions. J Chin Invest 1999;104:1097–105.
  • Yawalkar N, Ugucdoni M, Scharer J, Braunwalder J, Karlen S, Dewald B, et al. Enhanced expression of eotaxin and CCR3 in atopic dermatitis. J Invest Dermatol 1999;113:43–8.
  • Laberge S, Ghaffar 0, Boguniewicz M, Luster A, Hamid QA. Association of increased CD4+ T cell infiltration with increased IL-16 gene expression in atopic dermatitis. J Allergy Chin Immunol 1998;102: 645–50.
  • Santamaria Babi LF, Moser B, Perez Soler MT, Moser R, Loetscher P, Villiger B, et al. The interleukin-8 receptor B and CXC chemokines can mediate transendothelial migration of human skin homing T cells. Eur J Immunol 1996;26:2056–61.
  • Thompson CB. Apoptosis in the pathogenesis and treatment of disease. Science 1995;267:1456–62.
  • Green DR, Scott DW. Activation-induced apoptosis in lympho-cytes. Curr Opin Immunol 1994;6:476–87.
  • Akdis M, Trautmann A, Blaser K, Akdis CA. Life span of skin homing T cells in atopic dermatitis: survival in skin, activation induced apoptosis in peripheral blood. J Allergy Chin Immunol 2000;105:167.
  • Trautmarm A, Akdis M, Kleeman D, Altznauer F, Simon H-U, Graeve T, et al. T cell-mediated Fas-induced keratinocyte apoptosis plays a key pathogenetic role in eczematous dermatitis. J Chin Invest 2000;106:25–35.
  • Traidl C, Sebastiani S, Albanesi C, Merk HF, Puddu P, Girolomoni G, et al. Disparate cytotoxic activity of nickel-specific CD8+ and CD4+ T cell subsets against keratinocytes. J Immunol 2000;165:3058–64.
  • Schnyder B, Frutig K, Mauri-Hellweg D, Limat A, Yawalkar N, Pichler WJ. T-cell mediated cytotoxidty against keratinocytes in sulfamethoxazol-induced skin reactions. Chin Exp Allergy 1998; 28:1412–7.
  • Carroll JM, Crompton T, Seery JP, Watt FM. Transgenic mice expressing IFN-7 in the epidermis have eczema, hair hypopig-mentation and hair loss. J Invest Dermatol 1997;108:412–22.

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