Effects of polyhexamethylene guanidine phosphate on human gingival fibroblasts

References

• Rydén L, Buhlin K, Ekstrand E, et al. Periodontitis increases the risk of a first myocardial infarction A report from the PAROKRANK study. Circulation. 2016;133:576–583.
   PubMed Web of Science ®Google Scholar
• Durham J, Fraser HM, McCracken GI, et al. Impact of periodontitis on oral health-related quality of life. J Dent. 2013;41:370–376.
   PubMed Web of Science ®Google Scholar
• Hanes PJ, Purvis JP. Local anti-infective therapy: pharmacological agents. A systematic review. Ann Periodontol. 2003;8:79–98.
   PubMedGoogle Scholar
• Jones CG. Chlorhexidine: is it still the gold standard? Periodontol 2000. 1997;15:55–62.
   PubMed Web of Science ®Google Scholar
• McDonnell G, Russell AD. Antiseptics and disinfectants: activity, action, and resistance. Clin Microbiol Rev. 1999;12:147–179.
   PubMed Web of Science ®Google Scholar
• Mariotti AJ, Rumpf DA. Chlorhexidine-induced changes to human gingival fibroblast collagen and non-collagen protein production. J Periodontol. 1999;70:1443–1448.
   PubMed Web of Science ®Google Scholar
• Muller G, Kramer A. Biocompatibility index of antiseptic agents by parallel assessment of antimicrobial activity and cellular cytotoxicity. J Antimicrob Chemother. 2008;61:1281–1287.
   PubMed Web of Science ®Google Scholar
• Rosin M, Welk A, Bernhardt O, et al. Effect of a polyhexamethylene biguanide mouthrinse on bacterial counts and plaque. J Clin Periodontol. 2001;28:1121–1126.
   PubMed Web of Science ®Google Scholar
• Dissemond J, Gerber V, Kramer A, et al. A practice-oriented recommendation for treatment of critically colonised and locally infected wounds using polyhexanide. J Tissue Viability. 2010;19:106–115.
   PubMed Web of Science ®Google Scholar
• Ikeda T, Ledwith A, Bamford CH, et al. Interaction of a polymeric biguanide biocide with phospholipid membranes. Biochim Biophys Acta. 1984;769:57–66.
   PubMed Web of Science ®Google Scholar
• Gilbert P, Moore LE. Cationic antiseptics: diversity of action under a common epithet. J Appl Microbiol. 2005;99:703–715.
   PubMed Web of Science ®Google Scholar
• Vitt A, Sofrata A, Slizen V, et al. Antimicrobial activity of polyhexamethylene guanidine phosphate in comparison to chlorhexidine using the quantitative suspension method. Ann Clin Microbiol Antimicrob. 2015;14:36.
   PubMed Web of Science ®Google Scholar
• Garlet GP. Destructive and protective roles of cytokines in periodontitis: a re-appraisal from host defense and tissue destruction viewpoints. J Dent Res. 2010;89:1349–1363.
   PubMed Web of Science ®Google Scholar
• Lee S-H, Kim T-S, Choi Y, et al. Osteoimmunology: cytokines and the skeletal system. BMB Rep. 2008;41:495.
   PubMed Web of Science ®Google Scholar
• Behl Y, Siqueira M, Ortiz J, et al. Activation of the acquired immune response reduces coupled bone formation in response to a periodontal pathogen. J Immunol. 2008;181:8711–8718.
   PubMed Web of Science ®Google Scholar
• Asiedu-Gyekye IJ, Mahmood SA, Awortwe C, et al. A preliminary safety evaluation of polyhexamethylene guanidine hydrochloride. Int J Toxicol. 2014;33:523–531.
   PubMed Web of Science ®Google Scholar
• Yucel-Lindberg T, Olsson T, Kawakami T. Signal pathways involved in the regulation of prostaglandin E synthase-1 in human gingival fibroblasts. Cell Signal. 2006;18:2131–2142.
   PubMed Web of Science ®Google Scholar
• Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods. 1983;65:55–63.
   PubMed Web of Science ®Google Scholar
• Stabholz A, Nicholas AA, Zimmerman GJ, et al. Clinical and antimicrobial effects of a single episode of subgingival irrigation with tetracycline HCI or chlorhexidine in deep periodontal pockets. J Clin Periodontol. 1998;25:794–800.
   PubMed Web of Science ®Google Scholar
• Lee JE, Oum BS, Choi HY, et al. Cysticidal effect on acanthamoeba and toxicity on human keratocytes by polyhexamethylene biguanide and chlorhexidine. Cornea. 2007;26:736–741.
   PubMed Web of Science ®Google Scholar
• Hwang HJ, Nam J, Yang SI, et al. MALDI-TOF analysis of polyhexamethylene guanidine (PHMG) oligomers used as a commercial antibacterial humidifier disinfectant. Bull Korean Chem Soc. 2013;34:1708–1714.
   Web of Science ®Google Scholar
• Pantos A, Tsogas I, Paleos CM. Guanidinium group: a versatile moiety inducing transport and multicompartmentalization in complementary membranes. Biochim Biophys Acta (BBA)-Biomembr. 2008;1778:811–823.
   PubMed Web of Science ®Google Scholar
• Rudney JD, Chen R, Sedgewick GJ. Intracellular Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in buccal epithelial cells collected from human subjects. Infect Immun. 2001;69:2700–2707.
   PubMed Web of Science ®Google Scholar
• Muller G, Kramer A, Schmitt J, et al. Reduced cytotoxicity of polyhexamethylene biguanide hydrochloride (PHMB) by egg phosphatidylcholine while maintaining antimicrobial efficacy. Chem Biol Interact. 2011;190:171–178.
   PubMed Web of Science ®Google Scholar
• Rathbone MJ, Tucker IG. Mechanisms, barriers and pathways of oral mucosal drug permeation. Adv Drug Deliv Rev. 1993;12:41–60.
   Web of Science ®Google Scholar
• Dunn RL, Godowski KC, Harkrader RJ, et al. Mucosal delivery systems for treatment of periodontal disease. Google Patents. 1990.
   Google Scholar
• Tolo K. A study of permeability of gingival pocket epithelium to albumin in guinea pigs and Norwegian pigs. Arch Oral Biol. 1971;16:881IN11887IN13-886IN2888.
   PubMed Web of Science ®Google Scholar
• Haugen E, Johansen JR. Penetration of the oral mucosa by radiolabelled chlorhexidine in guinea pigs. Acta Odontol Scand. 1975;33:365–372.
   Web of Science ®Google Scholar
• Wei D, Ma Q, Guan Y, et al. Structural characterization and antibacterial activity of oligoguanidine (polyhexamethylene guanidine hydrochloride). Mater Sci Eng. 2009;29:1776–1780.
   Google Scholar
• Röhner E, Hoff P, Gaber T, et al. Cytokine expression in human osteoblasts after antiseptic treatment: a comparative study between polyhexanide and chlorhexidine. J Investig Surg. 2015;28:1–7.
   PubMed Web of Science ®Google Scholar
• Sakaki H, Matsumiya T, Kusumi A, et al. Interleukin-1beta induces matrix metalloproteinase-1 expression in cultured human gingival fibroblasts: role of cyclooxygenase-2 and prostaglandin E2. Oral Dis. 2004;10:87–93.
   PubMed Web of Science ®Google Scholar
• Hjeljord L, Rölla G, Bonesvoll P. Chlorhexidine–protein interactions. J Periodontal Res. 1973;8:11–16.
   PubMed Web of Science ®Google Scholar
• Cserháti T, Szögyi M, Lelkes L. Charge-transfer chromatography used to study the interaction of chlorhexidine with proteins and amino acids. J Liq Chromatogr Relat Technol. 1995;18:2175–2192.
   Web of Science ®Google Scholar
• Grenier D. Reduction of proteolytic degradation by chlorhexidine. J Dent Res. 1993;72:630–633.
   PubMed Web of Science ®Google Scholar
• Gendron R, Grenier D, Sorsa T, et al. Inhibition of the activities of matrix metalloproteinases 2, 8, and 9 by chlorhexidine. Clin Diagn Lab Immunol. 1999;6:437–439.
   PubMedGoogle Scholar
• Houri‐Haddad Y, Halabi A, Soskolne WA. Inflammatory response to chlorhexidine, minocycline HCl and doxycycline HCl in an in vivo mouse model. J Clin Periodontol. 2008;35:783–788.
   PubMed Web of Science ®Google Scholar
• Kida Y, Kobayashi M, Suzuki T, et al. Interleukin-1 stimulates cytokines, prostaglandin E2 and matrix metalloproteinase-1 production via activation of MAPK/AP-1 and NF-kappaB in human gingival fibroblasts. Cytokine. 2005;29:159–168.
   PubMed Web of Science ®Google Scholar
• Cserháti T, Szögyi M, Lelkes L. Charge-transfer chromatography used to study the interaction of chlorhexidine with proteins and amino acids. J Liquid Chromatogr. 1995;18:2175–2192.
   Web of Science ®Google Scholar
• Türkoğlu O, Becerik S, Emingil G, et al. The effect of adjunctive chlorhexidine mouthrinse on clinical parameters and gingival crevicular fluid cytokine levels in untreated plaque-associated gingivitis. Inflamm Res. 2009;58:277–283.
   PubMed Web of Science ®Google Scholar
• Hajishengallis G. Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response. Trends Immunol. 2014;35:3–11.
   PubMed Web of Science ®Google Scholar