797
Views
0
CrossRef citations to date
0
Altmetric
Original

High active local levels of vancomycin without nephrotoxicity released from impacted bone allografts in 20 revision hip arthroplasties

, , , &
Pages 336-340 | Received 30 Dec 2003, Accepted 20 Aug 2004, Published online: 08 Jul 2009

  • Askew M J, Kufel M F, Fleissner P R, Jr, Gradisar I A, Salstrom S J, Tan J S. Effect of vaccum mixing on the mechanical properties of antibiotic impregnated poly-methylmethacrylate bone cement. J Biomed Mater Res 1990; 24: 573–80
  • Brien W W, Salvati E A, Klein R, Brause B, Stern S. Antibiotic impregnated bone cement in total hip arthroplasty. An in vivo comparison of the elution properties of tobramycin and vancomycin. Clin Orthop 1993; 296: 242–8
  • Buttaro M A, González Della Valle A, Piñeiro L, Mocetti E, Morandi A, Piccaluga F. Vancomycin-supplemented bone allografts incorporation. Radiological, histopathological and immunohistochemical study in pigs. Acta Orthop Scand 2003; 74(5)505–13
  • Chohfi M, Langlais F, Fourastier J, Minet J, Thomazeu H, Cormier M. Pharmacokinetics, uses, and limitations of vancomycin-loaded bone cement. Int Orthop 1998; 22: 171–7
  • Gie G A, Linder L, Ling R S, Simon J P, Slooff T J, Timperley A J. Impacted cancellous allografts and cement for revision total hip arthroplasty. J Bone Joint Surg (Br) 1993; 75(1)14–21
  • Gonzalez Della Valle A, Bostrom M, Brause B, Harney C, Salvati E. Effective bactericidal activity of tobramycin and vancomycin eluted from acrylic bone cement. Acta Orthop Scand 2001; 72(3)237–40
  • Heck D, Rosenberg A, Schink-Ascani M, Garbus S, Kiewitt T. Use of antibiotic-impregnated cement during hip and knee arthroplasty in the United States. J Arthroplasty 1995; 10(4)470–5
  • Jolley M E. Fluorescence polarization immunoassay for the determination of therapeutic drug levels in human plasma. J Anal Toxicol 1981; 5(5)236–40
  • Jolley M E, Stroupe S D, Schwenzer K S, Wang C J, Lu-Steffes M, Hill H D, Popelka S R, Holen J T, Kelso D M. Fluorescence polarization immunoassay III. An automated system for therapeutic drug determination. Clin Chem 1981; 27(9)1575–9
  • Klekamp J, Dawson J M, Haas D W, DeBoer D, Christie M. The use of vancomycin and tobramycin in acrylic bone cement: Biomechanical effects and elution kinetics for use in joint arthroplasty. J Arthroplasty 1999; 14: 339–46
  • Laurencin C T, Gerhart T, Witschger P, Satcher R, Domb A, Rosenberg A E, Hanff P, Edsberg L, Hayes W, Langer R. Bioerodible polyanhydrides for antibiotic drug delivery: in vivo osteomyelitis treatment in a rat model system. J Orthop Res 1993; 11(2)256–62
  • Masri B A, Duncan C P, Beauchamp C P. Long-term elution of antibiotics from bonecement: an in vivo study using the prosthesis of antibiotic-loaded acrylic cement (PROS-TALAC) system. J Arthroplasty 1998; 13(3)331–8
  • Methodology for the serum bactericidal test: approved guideline. NCCLS document M21-A. 1999
  • Slooff T J, Huiskes R, van Horn J, Lemmens A J. Bone grafting in total hip replacement for acetabular protrusion. Acta Orthop Scand 1984; 55(6)593–6
  • Winkler H, Janata O, Berger C, Wein W, Geotgopoulos A. In vitro release of Vancomycin and tobramycin from impregnated human and bovine bone grafts. J Antimicrob Chemoter 2000; 46(3)423–8
  • Witsø E, Persen L, Loseth K, Bergh K. Adsorption and release of antibiotics from morselized cancellous bone. In vitro studies of 8 antibiotics. Acta Orthop Scand 1999; 70(3)298–304
  • Witsø E, Persen L, Loseth K, Bergh K. Cancellous bone as an antibiotic carrier. Acta Orthop Scand 2000; 71(3)80–4
  • Yu D, Wong J, Matsuda Y, Fox J L, Higuchi W I, Otsuka M. Self-setting hydroxyapatite cement: a novel skeletal drug-delivery system for antibiotics. J Pharm Sci 1992; 81(6)529–31
  • Zaske D E. Amynoglycosides. E E Evans, J J Schentag, W Jusko, V A Alexandria. Applied Therapeutics Inc. 1992; 7–31, Applied Therapeutics ed 3

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.