References
- Kohonen A, Tarkkanen J. Cochlear damage from oto-toxic antibiotics by intratympanic application. Acta Otolaryngol (Stockh) 1969; 68: 90–7.
- Brummett RE, Harris RF, Lindgren JA. Detection of ototoxicity of drugs applied directly to the middle ear space. Laryngoscope 1976; 86: 1177–87.
- Harada T, Nagai Y, Iwamori M, Nomura Y. Ototoxicity of neomycin and its penetration through the round window membrane into the perilymph. Ann Otol Rhinol Laryngol 1986; 95: 404–8.
- Priuska EA, Schacht J. Formation of free radicals by gentamicin and iron and evidence for an iron /gentamicin complex. Biochem Pharmacol 1995; 50: 1749–52.
- Song BB, Schacht J. Variable efficacy of radical scav-engers and iron chelators to attenuate gentamicin ototox-icity in the guinea pig in vivo. Hear Res 1996; 94: 87–93.
- Song BB, Anderson DJ, Schacht J. Protection from gentamicin ototoxicity by iron chelators in guinea pig in vivo. J Pharmacol Exp Ther 1997; 282: 369–77.
- Hirose K, Hockenbery DM, Rubel EW. Reactive oxygen species in chick hair cells after gentamicin exposure in vitro. Hear Res 1997; 104: 1–14.
- Hester TO, Jones RO, Clerici WJ. Protection against aminoglycoside otic drop-induced ototoxicity by a spin trap. I. Acute effects. Otolaryngol Head Neck Surg 1988; 119: 581–7.
- Garetz SL, Altschuler RA, Schacht J. Attenuation of gentamicin by glutathione in the guinea pig in vivo. Hear Res 1994; 77: 81–7.
- Clerici WJ, Hensley K, DiMartino DL, Butterfield DA. Direct detection of ototoxicant-induced reactive oxygen species generation in cochlear explants. Hear Res 1996; 98: 116–24.
- Conlon BJ, Perry B, Smith DW. Attenuation of neomycin ototoxicity by iron chelation. Laryngoscope 1998; 108: 284–7.
- Conlon BJ, Aran JM, Erre JP, Smith DW. Attenuation of aminoglycoside induced cochlear damage with the metabolic antioxidant alpha lipoic acid. Hear Res 1999; 128: 40–4.
- Packer L, Witt EH, Tritschler HJ. Alpha lipoic acid as a biological antioxidant. Free Radic Biol Med 1995; 19: 227–50.
- Conlon BJ, McSwain D, Smith DW. Topical gentamicin and ethacrynic acid: effects on cochlear function. Laryn-goscope 1998; 108: 1087–9.
- Halliwell B, Gutteridge JMC. Oxygen toxicity, oxygen radical, transition metals and disease. Biochem J 1984; 219: 1–14.
- LeBel CP, Bondy SC. Oxygen radicals: common media-tors of neurotoxicity. Neurotoxicol Teretol 1991; 13: 341–6.
- Pierson MG, Gray BH. Superoxide dismutase in the cochlea. Hear Res 1982; 6: 141–51.