99
Views
56
CrossRef citations to date
0
Altmetric
Research Article

The Anti-inflammatory Effect of Erythromycin and its Derivatives, with Special Reference to Nasal Polyposis and Chronic Sinusitis

Pages 83-92 | Published online: 08 Jul 2009

References

  • Hahn DL. Treatment of Chlamydia pneurnoniae infec-tion in adult asthma: a before-after trial [see com-ments]. J Fam Pract 1995; 41: 345–51.
  • Hendeles L. Erythromycin for the treatment of bronchial hyperresponsivene% in asthma [letter; com-ment]. Chest 1992; 101: 296.
  • Itkin IH, Menzel ML. The use of macrolide antibiotic substances in the treatment of asthma. J Allergy 1970; 45: 146–62.
  • Kamoi H, Kurihara N, Fujiwara H, Hirata K, Takeda T. The macrolide antibacterial roxithromycin reduces bronchial hyperresponsivene% and superoxide anion production by polymorphonuclear leukocytes in pa-tients with asthma. J Asthma 1995; 32: 191–7.
  • Miyatake H, Suzuki K, Taki F, Takagi K, Satake T. Effect of erythromycin on bronchial hyperresponsive-ness in patients with bronchial asthma. Arzneimit-telforschung 1991; 41: 552–6.
  • Shimizu T, Kato M, Mochizuki H, Tokuyama K, Morikawa A, Kuroume T. Roxithromycin reduces the degree of bronchial hyperresponsivene% in children with asthma. Chest 1994; 106: 458–61.
  • Tsang KW, Ho PI, Chan KN, et al. A pilot study of low-dose erythromycin in bronchiectasis. Eur Respir J 1999; 13: 361–4.
  • McGuire JM, Bunch RC, Anderson HE, Boaz HE, Flynn EH, Powell HM, Smith JW. "Ilotycin" an new antibiotic. Antibiot Chemother, 1952; 2(6): 281–3.
  • Sanda MA, Mandell GL. Macrolides (erythromycin, clarithromycin and azithromycin). In: Goodman LS, Gillman A, eds. The pharmacolgical basis of therapeu-tics, 9th Edn. New York: Macmillan, 1997: 1135–40.
  • Collins JG. Prevalence of selected chronic conditions: United States, 1990-1992. Vital Health Stat 1997; 10: 1–89.
  • Kaliner MA, Osguthorpe JD, Fireman P. Sinusitis: bench to bedside. Current findings, future directions [published erratum appears in Otolaryngol Head Neck Surg ; 1997 117: 187]. Otolaryngol Head Neck Surg 1997; 116: S1–20.
  • Ray NF, Baraniuk JN, Thamer M, et al. Healthcare expenditures for sinusitis in: 1996 contributions of asthma, rhinitis, and other airway disorders. J Allergy Clin Immunol 1999; 103: 408–14.
  • Gliklich RE, Metson R. The health impact of chronic sinusitis in patients seeking otolaryngologic care [see comments]. Otolaryngol Head Neck Surg 1995; 113: 104–9.
  • Winstead W, Barnett SN. Impact of endoscopic sinus surgery on global health perception: an outcomes study. Otolaryngol Head Neck Surg 1998; 119: 486–91.
  • Georgitis JW, Matthews BL, Stone B. Chronic sinusi-tis: characterization of cellular influx and inflammatory mediators in sinus lavage fluid. Int Arch Allergy Im-munol 1995; 106: 416–21.
  • Bachert C, Wagenmann M, Rudack C, et al. The role of cytokines in infectious sinusitis and nasal polyposis. Allergy 1998; 53: 2–13.
  • Demoly P, Crampette L, Mondain M, Enander I, Jones I, Bousquet J. Myeloperoxidase and interleukin-8 levels in chronic sinusitis. Clin Exp Allergy 1997; 27: 672–5.
  • Rudack C, Stoll W, Bachert C. Cytokines in nasal polyposis, acute and chronic sinusitis. Am J Rhinol 1998; 12: 383–8.
  • Maran A, Lund V. Clinical Rhinology. New York: Thieme, 1990.
  • Settipane G, Chafee F. Nasal polyps in asthma and rhinitis: a review of 6,037 patients. J Allergy Clin Immunol 1977; 59: 17–21.
  • Perkins J, Blakeslee D, Andrade P. Nasal polyps: a manifestation of allergy? Otolaryngol Head Neck Surg 1989; 101: 641–5.
  • Allen JS, Eisma R, Leonard G, Lafreniere D, Kreutzer D. Interleukin-8 expression in human nasal polyps. Otolaryngol Head Neck Surg 1997; 117: 535–41.
  • Allen JS, Eisma R, Leonard G, Kreutzer D. Inter-leukin-3, interleukin-5, and granulocyte-macrophage colony-stimulating factor expression in nasal polyps. Am J Otolaryngol 1997; 18: 239–46.
  • Bachert C, Wagenmann M, Hauser U, Rudack C. IL-5 synthesis is upregulated in human nasal polyp tissue. J Allergy Clin Immunol 1997; 99: 837–42.
  • Smith D, Gerrard J, White J. Comparision of arachi-donic acid metabolism in nasal polyps and eosinophils. Int Arch Allergy Appl Immunol 1987; 82: 83–8.
  • Kudoh S. Erythromycin treatment in diffuse panbron-chiolitis. Curr Opin Pulm Med 1998; 4: 116–21.
  • Kikuchi S, Susaki H, Aoki A, Ito 0, Nomura Y. Clinical effect of long-term low-dose erythromycin therapy for chronic sinusitis. Pract Otol (Kyoto) 1991; 84: 41–7 (in Japanese with English abstract).
  • Hashiba M, Baba S. Efficacy of long-term administra-tion of clarithromycin in the treatment of intractable chronic sinusitis. Acta Otolaryngol (Stockh) 1996; 525 (Suppl): 73–8.
  • lino Y, Sugita K, Toriyama M, Kudo K. Erythromycin therapy for otitis media with effusion in sinobronchial syndrome. Arch Otolaryngol Head Neck Surg 1993; 119: 648–51.
  • Rubin BK, Druce H, Ramirez OE, Palmer R. Effect of clarithromycin on nasal mucus properties in healthy subjects and in patients with purulent rhinitis. Am J Respir Crit Care Med 1997; 155: 2018–23.
  • Nishi K, Mizuguchi M, Tachibana H, et al. Effect of clarithromycin on symptoms and mucociliary transport in patients with sino-bronchial syndrome. Nippon Ky-obu Shikkan Gakkai Zasshi 1995; 33: 1392–400 (En-glish abstract only).
  • Suzuki H, Shimomura A, Ikeda K, Oshima T, Takasaka T. on on neutrophil recruitment and IL-8 in the nasal discharge of chronic sinusitis patients. To-hoku J Exp Med 1997; 182: 115–24 (English abstract only).
  • Ichimura K, Shimazaki Y, Ishibashi T, Higo R. Effect of new macrolide roxithromycin upon nasal polyps associated with chronic sinusitis. Auris Nasus Larynx 1996; 23: 48–56.
  • Nonaka M, Pawankar R, Tomiyama S, Yagi T. A macrolide antibiotic, roxithromycin, inhibits the growth of nasal polyp fibroblasts. Am J Rhinol 1999; 13: 267–72.
  • Kohyama T, Takizawa H, Kawasaki S, Akiyama N, Sato M, Ito K. Fourteen-member macrolides inhibit interleukin-8 release by human eosinophils from atopic donors. Antimicrob Agents Chemother 1999; 43: 907–11.
  • Suzuki H, Shimomura A, Ikeda K, Furukawa M, Oshima T, Takasaka T. Inhibitory effect of macrolides on interleukin-8 secretion from cultured human nasal epithelial cells. Laryngoscope 1997; 107: 1661–6.
  • Scaglione F, Rossoni G. Comparative anti-inflamma-tory effects of roxithromycin, azithromycin and clarithromycin. J Antimicrob Chemother 1998; 41 ((Suppl B)): 47–50.
  • Nakano T, Ohashi Y, Tanaka A, Kakinoki Y, Washio Y, Nakai Y. Roxythromycin reinforces epithelial defence function in rabbit trachea. Acta Otolaryngol (Stockh) 1998; 538 (Suppl): 233–8.
  • Sugiura Y, Ohashi Y, Nakai Y. Roxythromycin stimu-lates the mucociliary activity of the Eustachian tube and modulates neutrophil activity in the healthy guinea pig. Acta Otolaryngol (Stockh) 1997; 531 (Suppl): 34–8.
  • Tamaoki J, Takeyama K, Yamawaki I, Kondo M, Konno K. Lipopolysaccharide-induced goblet cell hy-persecretion in the guinea pig trachea: inhibition by macrolides. Am J Physiol 1997; 272: L15–9.
  • Chin AC, Morck DW, Merrill JK, et al. Anti-inflam-matory benefits of tilmicosin in calves with Pasteurella haemolytica-infected lungs. Am J Vet Res 1998; 59: 765–71.
  • Aoshiba K, Nagai A, Konno K. Erythromycin short-ens neutrophil survival by accelerating apoptosis [pub-lished erratum appears in Antimicrob Agents Chemother ; 1997 41: 1847]. Antimicrob Agents Chemother 1995; 39: 872–7.
  • Baeuerle PA, Baltimore D. I kappa B: a specific in-hibitor of the NF-kappa B transcription factor. Science 1988; 242: 540–6.
  • DiMango E, Ratner AJ, Bryan R, Tabibi S, Prince A. Activation of NF-kappaB by adherent Pseudomonas aeruginosa in normal and cystic fibrosis respiratory epithelial cells. J Clin Invest 1998; 101: 2598–605.
  • Bitko V, Velazquez A, Yang L, Yang YC, Bank S. Transcriptional induction of multiple cytokines by hu-man respiratory syncytial virus requires activation of NF-kappa B and is inhibited by sodium salicylate and aspirin. Virology 1997; 232: 369–78.
  • Papi A, Johnston SL. Rhinovirus infection induces expression of its own receptor intercellular adhesion molecule 1 (ICAM-1) via increased NF-kappaB-medi-ated transcription. J Biol Chem 1999; 274: 9707–20.
  • Zhu Z, Tang W, Ray A, et al. Rhinovirus stimulation of interleukin-6 in vivo and in vitro. Evidence for nu-clear factor kappa B-dependent transcriptional activa-tion. J Clin Invest 1996; 97: 421–30.
  • Zhu Z, Tang W, Gwaltney JM Jr, Wu Y, Elias JA. Rhinovirus stimulation of interleukin-8 in vivo and in vitro: role of NF-kappaB. Am J Physiol 1997; 273: L814–24.
  • Mori N, Oishi K, Sar B, et al. Essential role of transcription factor nuclear factor-kappaB in regula-tion of interleukin-8 gene expression by nitrite reduc-tase from Pseudomonas aeruginosa in respiratory epithelial cells. Infect Immunol 1999; 67: 3872–8.
  • Miyanohara T, Ushikai M, Matsune S, Ueno K, Katahira S, Kurono Y. Effects of clarithromycin on cultured human nasal epithelial cells and fibroblasts. Laryngoscope 2000; 110: 126–31.
  • Berkman N, Krishnan VL, Gilbey T, et al. Expression of RANTES mRNA and protein in airways of patients with mild asthma. Am J Respir Crit Care Med 1996; 154: 1804–11.
  • Cembrzynska-Nowak M, Szklarz E, Inglot AD, Teodorczyk-Injeyan JA. Elevated release of tumor ne-crosis factor-alpha and interferon-gamma by bron-choalveolar leukocytes from patients with bronchial asthma. Am Rev Respir Dis 1993; 147: 291–5.
  • Gosset P, Tillie-Leblond I, Janin A, et al. Expression of E-selectin, ICAM-1 and VCAM-1 on bronchial biop-sies from allergic and non-allergic asthmatic patients. Int Arch Allergy Immunol 1995; 106: 69–77.
  • Hallsworth MP, Soh CP, Lane SJ, Arm JP, Lee TH. Selective enhancement of GM-CSF, TNF-alpha, IL-1 beta and IL-8 production by monocytes and macrophages of asthmatic subjects. Eur Respir J 1994; 7: 1096–102.
  • Hamid Q, Springall DR, Riveros-Moreno V, et al. Induction of nitric oxide synthase in asthma. Lancet 1993; 342: 1510–3.
  • Sousa AR, Poston RN, Lane SJ, Nakhosteen JA, Lee TH. Detection of GM-CSF in asthmatic bronchial epithelium and decrease by inhaled corticosteroids Am Rev Respir Dis 1993; 147: 1557–61.
  • Sousa AR, Lane SJ, Nakhosteen JA, Yoshimura T, Lee TH, Poston RN. Increased expression of the monocyte chemoattractant protein-1 in bronchial tissue from asthmatic subjects. Am J Respir Cell Mol Biol 1994; 10: 142–7.
  • Baeuerle PA, Henkel T. Function and activation of NF-kappa B in the immune system. Annu Rev Im-munol 1994; 12: 141–79.
  • Aoki Y, Kao PN. Erythromycin inhibits transcrip-tional activation of NF-kappaB, but not NFAT, through calcineurin-independent signaling in T cells. Antimicrob Agents Chemother 1999; 43: 2678–84.
  • Tamaoki J, Kondo M, Kohri K, Aoshiba K, Tagaya E, Nagai A. Macrolide antibiotics protect against immune complex-induced lung injury in rats: role of nitric oxide from alveolar macrophages. J Immunol 1999; 163: 2909–15.
  • Takizawa H, Desaki M, Ohtoshi T, et al. Erythromycin suppresses interleukin 6 expression by human bronchial epithelial cells: a potential mechanism of its anti-infl-ammatory action. Biochem Biophys Res Commun 1995; 210: 781–6.
  • Takizawa H, Desaki M, Ohtoshi T, et al. Erythromycin modulates IL-8 expression in normal and inflamed human bronchial epithelial cells. Am J Respir Crit Care Med 1997; 156: 266–71.
  • Abe S, Nakamura H, Inoue S, et al. Interleukin-8 gene repression by clarithromycin is mediated by the activa-tor protein-1 binding site in human bronchial epithelial cells. Am J Respir Cell Mol Biol 2000; 22: 51–60.
  • Anderson R, Theron AJ, Feldman C. Membrane-stabi-lizing, anti-inflammatory interactions of macrolides with human neutrophils. Inflammation 1996; 20: 693–705.
  • Coste A, Lefaucheur JP, Wang QP, et al. Expression of the transforming growth factor beta isoforms in inflam-matory cells of nasal polyps. Arch Otolaryngol Head Neck Surg 1998; 124: 1361–6.
  • Wang T, Donahoe PK, Zervos AS. Specific interaction of type I receptors of the TGF-beta family with the immunophilin FKBP-12. Science 1994; 265: 674–6.
  • Newton R, Hart LA, Stevens DA, et al. Effect of dexamethasone on interleukin-lbeta-(IL-lbeta)-in-duced nuclear factor-kappaB (NF-kappaB) and kap-paB-dependent transcription in epithelial cells. Eur J Biochem 1998; 254: 81–9.
  • Hart L, Lim S, Adcock I, Barnes PJ, Fan Chung K. Effects of inhaled corticosteroid therapy on expression and DNA-binding activity of nuclear factor kappaB in asthma. Am J Respir Crit Care Med 2000; 161: 224–31.
  • Hahn DL, Bukstein D, Luskin A, Zeitz H. Evidence for Chlamydia pneumoniae infection in steroid-depen-dent asthma. Ann Allergy Asthma Immunol 1998; 80: 45–9.
  • Thom DH, Grayston if, Campbell LA, Kuo CC, Diwan VK, Wang SP. Respiratory infection with Chlamydia pneumoniae in middle-aged and older adult outpatients Eur J Clin Microbiol Infect Dis 1994; 13: 785–92.
  • Sofer D, Gilboa-Garber N, Belz A, Garber NC. Subinhibitor37 erythromycin represses production of Pseudomonas aeruginosa lectins, autoinducer and viru-lence factors. Chemotherapy 1999; 45: 335–41.
  • Ozeki M, Miyamoto N, Hashiba M, Baba S. Inhibitory effect of roxithromycin on biofilm formation of Pseu-domonas aeruginosa. Acta Otolaryngol Suppl 1996; 525: 61–3.
  • Feldman C, Anderson R, Theron AJ, Ramafi G, Cole PJ, Wilson R. Roxithromycin, clarithromycin, and azithromycin attenuate the injurious effects of bioactive phospholipids on human respiratory epithelium in vitro. Inflammation 1997; 21: 655–65.
  • Kawasaki S, Takizawa H, Ohtoshi T, et al. Rox-ithromycin inhibits cytokine production by and neu-trophll attachment to human bronchial epithelial cells in vitro. Antimicrob Agents Chemother 1998; 42: 1499–502.
  • Nonaka M, Pawankar R, Saji F, Yagi T. Effect of roxithromycin on IL-8 synthesis and proliferation of nasal polyp fibroblasts. Acta Otolaryngol (Stockh) 1998; 539 (Suppl): 71–5.
  • Khair OA, Devalia JL, Abdelaziz MM, Sapsford RJ, Davies RJ. Effect of erythromycin on Haemophilus influenzae endotoxin-induced release of IL-6, IL-8 and sICAM-1 by cultured human bronchial epithelial cells. Eur Respir J 1995; 8: 1451–7.
  • Takizawa H, Desaki M, Ohtoshi T, et al. Erythromycin and clarithromycin attenuate cytokine-induced endothe-lin-1 expression in human bronchial epithelial cells. Eur Respir J 1998; 12: 57–63.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.