Advanced search
Publication Cover
Acta Oto-Laryngologica Volume 125, 2005 - Issue 4
Submit an article Journal homepage
85
Views
25
CrossRef citations to date
0
Altmetric
Original Article: Inner Ear

Cochlear hair cell loss in single-dose versus continuous round window administration of gentamicin

Niels Wagner Departments of Otorhinolaryngology, Head and Neck Surgery, Gentofte University Hospital of Copenhagen, Hellerup, DenmarkCorrespondence[email protected]
,
Per Cayé-Thomasen Departments of Otorhinolaryngology, Head and Neck Surgery, Gentofte University Hospital of Copenhagen, Hellerup, Denmark
,
Göran Laurell Departments of Otorhinolaryngology, Head and Neck Surgery, Karolinska University Hospital, Stockholm, Sweden
,
Dan Bagger-Sjöbäck Departments of Otorhinolaryngology, Head and Neck Surgery, Karolinska University Hospital, Stockholm, Sweden
&
Jens Thomsen Departments of Otorhinolaryngology, Head and Neck Surgery, Gentofte University Hospital of Copenhagen, Hellerup, Denmark
Pages 340-345 | Received 14 Jun 2004, Accepted 07 Oct 2004, Published online: 08 Jul 2009

References

  • Blakley BW. Clinical forum: a review of intratympanic therapy. Am J Otol 1997;18:520–6.
  • Wu IC, Minor LB. Long-term hearing outcome in patients receiving intratympanic gentamicin for Méniere's disease. Laryngoscope 2003;113:815–20.
  • Alzamil KS, Linthicum FH. Extraneous round window membranes and plugs: possible effect on intratympanic therapy. Ann Otol Rhinol Laryngol 2000;109:30–2.
  • Silverstein H, Todd Rowan P, Olds MJ, Rosenberg SI. Inner ear perfusion and role of round window patency. Am J Otol 1997;18:586–9.
  • Thomsen J, Charabi S, Tos M. Preliminary results of a new delivery system for gentamicin to the inner ear in patients with Meniere's disease. Eur Arch Otorhinolaryngol 2000; 257:362–5.
  • Hoffer ME, Kopke RD, Weisskopf P, Gottshall K, Allen K, Wester D, et al. Use of the round window microcatheter in the treatment of Menieres disease. Laryngoscope 2001;111: 2046–9.
  • Schoendorf J, Neugebauer P, Michel 0. Continuous intratympanic infusion via a microcatheter in Meni-ere's disease. Otolaryngol Head Neck Surg 2001;124: 203–7.
  • Lefebvre PP, Staecker H. Steroid perfusion of the inner ear for sudden sensorineural hearing loss after failure of con-ventional therapy: a pilot study. Acta Otolaryngol 2002;122: 698–702.
  • Cayé-Thomasen P, Wagner N, Engmer C, Lauréll G, Bagger-Sjöbäck D, Thomsen J. An animal model for con-tinuous drug administration to the inner ear. Audiol Med 2004;2:174–8.
  • Johnson A-C, Canlon B. Progressive hair cell loss induced by toluene exposure. Hear Res 1994;75:201–8.
  • Oei ML, Segenhout HM, Dijk F, Stokroos I, van der Want JJ, Albers FW. Functional and anatomic alterations in the gentamicin-damaged vestibular system in the guinea pig. Otol Neurotol 2004;25:57–64.
  • Hoffer ME, Allen K, Kopke RD, Weisskopf P, Gottshall K, Wester D. Transtympanic versus sustained release adminis-tration of gentamicin: kinetics, morphology, and function. Laryngoscope 2001;111:1343–57.
  • Hibi T, Suzuki T, Nakashima T. Perilymphatic concentra-tion of gentamicin administered intratympanically in guinea pigs. Acta Otolaryngol 2001;121:336–41.
  • Plontke S, Wood AW, Salt AN. Analysis of gentamicin kinetics in fluids of the inner ear with round window administration. Otol Neurotol 2002;23:967–74.
  • Saijo S, Kimura RS. Distribution of HRP in the inner ear after injection into the middle ear cavity. Acta Otolaryngol (Stockh) 1984;97:593–610.
  • Salt AN, Ohyama K, Thalman R. Radial communi-cation between the perilymphatic scalae of the cochlea. II: Estimation by bolus injection of tracer into the sealed cochlea. Hear Res 1991;51:37–43.
  • Laurell G, Teixeira M, Sterkers 0, Bagger-Sjöbäck D, Eksborg S, Lidman 0, et al. Local administration of antioxidants to the inner ear. Hear Res 2002;173: 198–209.
  • Imamura S, Adams JC. Distribution of gentamicin in the guinea pig inner ear after local or systemic application. J Assoc Res Otolaryngol 2003;4:176–95.
  • Imamura S, Adams JC. Changes in cytochemistry of sensory and nonsensory cells in gentamicin-treated cochleas. J Assoc Res Otolaryngol 2003;4:196–218.
  • Salt AN, Kellner C, Hale S. Contamination of perilymph sampled from the basal cochlear turn with cerebrospinal fluid. Hear Res 2003;182:24–33.
  • Walsted A. Unpredictable hearing loss after intratympanic gentamicin treatment for vertigo. A new theory. Acta Otolaryngol 2001;121:42 —4.
  • Rask-Andersen H, Stahle J, Wilbrand H. Human cochlear aqueduct and its accessory canals. Ann Otol Rhinol Laryngol Suppl 1977;42:1–16.
  • Assimakopoulos D, Patrikakos G. Treatment of Meniere's disease by intratympanic gentamicin application. J Laryngol Otol 2003;117:10 — 6.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.