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MOUTH/PHARYNX

A zinc-containing compound, Polaprezinc, is effective for patients with taste disorders: randomized, double-blind, placebo-controlled, multi-center study

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Pages 1115-1120 | Received 20 Aug 2008, Published online: 19 Sep 2009

References

  • Hoffman HJ, Ishii EK, MacTurk RH. Age-related changes in the prevalence of smell/taste problems among the United States adult population. Results of the 1994 disability supplement to the National Health Interview Survey (NHIS). Ann N Y Acad Sci 1998; 855: 716–22
  • Ikeda M, Aiba T, Ikui A, Inokuchi A, Kurono Y, Sakagami M, et al. Taste disorders: a survey of the examination methods and treatments used in Japan. Acta Otolaryngol 2005; 125: 1203–10
  • Rareshide E, Amedee RG. Disorders of taste. J L A State Med Soc 1989; 141: 9–11
  • Henkin RI, Schechter PJ, Hoye R, Mattern CFT. Idiopathic hypogeusia with dysgeusia, hyposmia, and dysosmia. A new syndrome. JAMA 1971; 217: 434–40
  • Naganuma M, Ikeda M, Tomita H. Changes in soft palate taste buds of rats due to aging and zinc deficiency – scanning electron microscopic observation. Auris Nasus Larynx 1988; 15: 117–27
  • Vallee BL, Falchuk KH. The biochemical basis of zinc physiology. Physiol Rev 1993; 73: 79–118
  • Kobayashi T, Tomita H. Electron microscopic observation of vallate taste buds of zinc-deficient rats with taste disturbance. Auris Nasus Larynx 1986; 13(Suppl)S25–S31
  • Henkin RI, Bradley DF. Hypoguesia corrected by N+ + and Zn+ +. Life Sci 1970; 9: 701–9
  • Schechter PJ, Friedewald WT, Bronzert DA, Raff MS, Henkin RI. Idiopathic hypogeusia: a description of the syndrome and a single-blind study with zinc sulfate. International Review of Neurobiology. Academic Press, New York 1972; 125–40
  • Sakai F, Yoshida S, Endo S, Tomita H. Double-blind, placebo-controlled trial of zinc picolinate for taste disorders. Acta Otolaryngol (Suppl) 2002; 546: 129–33
  • Yoshida S, Endo S, Tomita H. A double-blind study of the therapeutic efficacy of zinc gluconate on taste disorder. Auris Nasus Larynx 1991; 18: 153–61
  • Heckmann SM, Hujoel P, Habiger S, Friess W, Wichmann M, Heckmann JG, et al. Zinc gluconate in the treatment of dysgeusia – a randomized clinical trial. J Dent Res 2005; 84: 35–8
  • Tomita H, Ikeda M, Okuda Y. Basis and practice of clinical taste examinations. Auris Nasus Larynx 1986; 13((Suppl))S1–S15
  • Heyneman CA. Zinc deficiency and taste disorders. Ann Pharmacother 1996; 30: 186–7
  • Atkin-Thor E, Goddard BW, O'Nion J, Stephen RL, Kolff WJ. Hypogeusia and zinc depletion in chronic dialysis patients. Am J Clin Nutr 1978; 31: 1948–51
  • Madden AM, Bradbury W, Morgan MY. Taste Perception in cirrhosis: its relationship to circulating micronutrients and food preferences. Hepatology 1997; 26: 40–8
  • Ripamonti C, Zecca E, Brunelli C, Fulfaro F, Villa S, Balzarini A, et al. A randomized, controlled clinical trial to evaluate the effect of zinc sulfate on cancer patients with taste alterations caused by head and neck irradiation. Cancer 1998; 82: 1938–45
  • Matsukura T, Tanaka H. Applicability of zinc complex of L-carnocine for medical use. Biochemistry (Mosc) 2000; 65: 817–23
  • Hamano H, Yoshinaga K, Eta R, Emori Y, Kawasaki D, Iino Y, et al. Effect of polaprezinc on taste disorders in zinc-deficient rats. Biofactors 2006; 28: 185–93
  • Ikeda M, Ikui A, Komiyama A, Kobayashi D, Tanaka M. Causative factors of taste disorders in the elderly, and therapeutic effects of zinc. J Laryngol Otol 2008; 122: 155–60

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