184
Views
1
CrossRef citations to date
0
Altmetric
Research Article

Involvement of p53 and Bcl-2 in sensory cell degeneration in aging rat cochleae

, , , &
Pages 572-580 | Received 14 Oct 2016, Accepted 08 Dec 2016, Published online: 17 Jan 2017

References

  • Cruickshanks KJ, Wiley TL, Tweed TS, Klein BE, Klein R, Mares-Perlman JA, Nondahl DM. Prevalence of hearing loss in older adults in Beaver Dam, Wisconsin. The Epidemiology of Hearing Loss Study. Am J Epidemiol 1998;148:879–86.
  • Van Eyken E, Van Camp G, Van Laer L. The complexity of age-related hearing impairment: contributing environmental and genetic factors. Audiol Neurootol 2007;12:345–58.
  • Perez P, Bao J. Why do hair cells and spiral ganglion neurons in the cochlea die during aging? Aging Dis 2011;2:231–41.
  • Sha SH, Kanicki A, Dootz G, Talaska AE, Halsey K, Dolan D, et al. Age-related auditory pathology in the CBA/J mouse. Hear Res 2008;243:87–94.
  • Hu BH, Yang WP, Bielefeld EC, Li M, Chen G-D, Henderson D. Apoptotic outer hair cell death in the cochleae of aging Fischer 344/NHsd rats. Hear Res 2008;245:48–57.
  • Yang WP, Hu BH, Sun JH, Zhai SQ, Henderson D. Death mode-dependent reduction in succinate dehydrogenase activity in hair cells of aging rat cochleae. Chin Med J 2010;123:1633–8.
  • Sha SH, Chen FQ, Schacht J. Activation of cell death pathways in the inner ear of the aging CBA/J mouse. Hear Res 2009;254:92–9.
  • Yang WP, Guo WW, Liu HZ, Xu Y, Chen L, Hu BH. Age-related changes in the ratio of Mcl-1/Bax expression in the rat cochlea. Acta Otolaryngol 2012;132:123–32.
  • Wang J, Menchenton T, Yin S, Yu Z, Bance M, Morris DP, et al. Over-expression of X-linked inhibitor of apoptosis protein slows presbycusis in C57BL/6J mice. Neurobiol Aging 2010;31:1238–49.
  • Yang WP, Xu Y, Guo WW, Liu HZ, Hu BH. Modulation of Mcl-1 expression reduces age-related cochlear degeneration. Neurobiol Aging 2013;34:2647–58.
  • Schuler M, Bossy-Wetzel E, Goldstein JC, Fitzgerald P, Green DR. p53 induces apoptosis by caspase activation through mitochondrial cytochrome c release. J Biol Chem 2000;275:7337–42.
  • Tadros SF, D'Souza M, Zhu X, Frisina RD. Apoptosis-related genes change their expression with age and hearing loss in the mouse cochlea. Apoptosis 2008;13:1303–21.
  • Ashcroft M, Vousden KH. Regulation of p53 stability. Oncogene 1999;18:7637–43.
  • Fetoni AR, Bielefeld EC, Paludetti G, Nicotera T, Henderson D. A putative role of p53 pathway against impulse noise induced damage as demonstrated by protection with pifithrin-alpha and a Src inhibitor. Neurosci Res 2014;81/82:30–7.
  • Baumann K. Cell death: multitasking p53 promotes necrosis. Nat Rev Mol Cell Biol 2012;13:480–1.
  • Cunningham LL, Matsui JI, Warchol ME, Rubel EW. Overexpression of Bcl-2 prevents neomycin-induced hair cell death and caspase-9 activation in the adult mouse utricle in vitro. J Neurobiol 2004;60:89–100.
  • Miyashita T, Krajewski S, Krajewska M, Wang HG, Lin HK, Liebermann DA, et al. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene 1994;9:1799–805.
  • Mihara M, Erster S, Zaika A, Petrenko O, Chittenden T, Pancoska P, Moll UM. p53 has a direct apoptogenic role at the mitochondria. Mol Cell 2003;11:577–90.
  • Zhan Q, Kontny U, Iglesias M, Alamo I Jr, Yu K, Hollander MC, Woodworth CD, Fornace AJ Jr. Inhibitory effect of Bcl-2 on p53-mediated transactivation following genotoxic stress. Oncogene 1999;18:297–304.
  • Ryan JJ, Prochownik E, Gottlieb CA, Apel IJ, Merino R, Nuñez G, Clarke MF. c-myc and bcl-2 modulate p53 function by altering p53 subcellular trafficking during the cell cycle. Proc Natl Acad Sci USA 1994;91:5878–82.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.