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Acta Oto-Laryngologica Volume 137, 2017 - Issue 10
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Research Article

Cisplatin-induced metabolome changes in serum: an experimental approach to identify markers for ototoxicity

Pernilla Videhult PierreDepartment of Surgical Sciences, Uppsala University, Uppsala University Hospital, ENT Clinic, Uppsala, Sweden; ;Department of Clinical Science, Intervention, and Technology, Division of Audiology, Karolinska Institutet, Huddinge, Sweden; Correspondence[email protected]
View further author information
,
Jakob HaglöfDepartment of Medicinal Chemistry, Division of Analytical Pharmaceutical Chemistry, Uppsala University, Uppsala, Sweden; View further author information
,
Birgitta LinderDepartment of Surgical Sciences, Uppsala University, Uppsala University Hospital, ENT Clinic, Uppsala, Sweden; View further author information
,
Mikael K. R. EngskogDepartment of Medicinal Chemistry, Division of Analytical Pharmaceutical Chemistry, Uppsala University, Uppsala, Sweden; View further author information
,
Torbjörn ArvidssonDepartment of Medicinal Chemistry, Division of Analytical Pharmaceutical Chemistry, Uppsala University, Uppsala, Sweden; ;Medical Product Agency, Uppsala, SwedenView further author information
,
Curt PetterssonDepartment of Medicinal Chemistry, Division of Analytical Pharmaceutical Chemistry, Uppsala University, Uppsala, Sweden; View further author information
,
Anette FranssonDepartment of Surgical Sciences, Uppsala University, Uppsala University Hospital, ENT Clinic, Uppsala, Sweden; View further author information
&
Göran LaurellDepartment of Surgical Sciences, Uppsala University, Uppsala University Hospital, ENT Clinic, Uppsala, Sweden; ORCID Iconhttp://orcid.org/0000-0002-7760-246XView further author information
ORCID Icon show all
Pages 1024-1030 | Received 15 Mar 2017, Accepted 25 Apr 2017, Published online: 24 May 2017

References

  • Rybak LP, Whitworth CA, Mukherjea D, et al. Mechanisms of cisplatin-induced ototoxicity and prevention. Hear Res. 2007;226:157–167.
  • Gika HG, Theodoridis GA, Plumb RS, et al. Current practice of liquid chromatography-mass spectrometry in metabolomics and metabonomics. J Pharm Biomed Anal. 2014;87:12–25.
  • Galluzzi L, Vitale I, Michels J, et al. Systems biology of cisplatin resistance: past, present and future. Cell Death Dis. 2014;5:e1257.
  • Laurell G, Ekborn A, Viberg A, et al. Effects of a single high dose of cisplatin on the melanocytes of the stria vascularis in the guinea pig. Audiol Neurootol. 2007;12:170–178.
  • Engskog MK, Ersson L, Haglof J, et al. beta-N-Methylamino-L-alanine (BMAA) perturbs alanine, aspartate and glutamate metabolism pathways in human neuroblastoma cells as determined by metabolic profiling. Amino Acids. 2017;49:905–919.
  • Trygg J, Holmes E, Lundstedt T. Chemometrics in metabonomics. J Proteome Res. 2007;6:469–479.
  • Freyer DR, Chen L, Krailo MD, et al. Effects of sodium thiosulfate versus observation on development of cisplatin-induced hearing loss in children with cancer (ACCL0431): a multicentre, randomised, controlled, open-label, phase 3 trial. Lancet Oncol. 2017;18:63–74.
  • Riedl S, Zweytick D, Lohner K. Membrane-active host defense peptides-challenges and perspectives for the development of novel anticancer drugs. Chem Phys Lipids. 2011;164:766–781.
  • Schauer R. Achievements and challenges of sialic acid research. Glycoconj J. 2000;17:485–499.
  • Sillanaukee P, Ponnio M, Jaaskelainen IP. Occurrence of sialic acids in healthy humans and different disorders. Eur J Clin Invest. 1999;29:413–425.
  • Kart A, Yapar K, Karapehlivan M, et al. Effects of L-carnitine on kidney histopathology, plasma and tissue total sialic acid, malondialdehyde and glutathione concentrations in response to gentamicin administration in Balb/C mice. Revue Méd Vét. 2006;157:179–184.
  • de Groot JC, Hendriksen EG, Smoorenburg GF. Reduced expression of sialoglycoconjugates in the outer hair cell glycocalyx after systemic aminoglycoside administration. Hear Res. 2005;205:68–82.
  • Onofrj M, Ciccocioppo F, Varanese S, et al. Acetyl-L-carnitine: from a biological curiosity to a drug for the peripheral nervous system and beyond. Expert Rev Neurother. 2013;13:925–936.
  • Haschke M, Vitins T, Lude S, et al. Urinary excretion of carnitine as a marker of proximal tubular damage associated with platin-based antineoplastic drugs. Nephrol Dial Transplant. 2010;25:426–433.
  • Devarajan P, Savoca M, Castaneda MP, et al. Cisplatin-induced apoptosis in auditory cells: role of death receptor and mitochondrial pathways. Hear Res. 2002;174:45–54.
  • Yang Y, Liu H, Liu F, et al. Mitochondrial dysregulation and protection in cisplatin nephrotoxicity. Arch Toxicol. 2014;88:1249–1256.
  • Gunes D, Kirkim G, Kolatan E, et al. Evaluation of the effect of acetyl L-carnitine on experimental cisplatin ototoxicity and neurotoxicity. Chemotherapy. 2011;57:186–194.
  • Galadari S, Rahman A, Pallichankandy S, et al. Tumor suppressive functions of ceramide: evidence and mechanisms. Apoptosis. 2015;20:689–711.
  • Roh JL, Park JY, Kim EH, et al. Targeting acid ceramidase sensitises head and neck cancer to cisplatin. Eur J Cancer. 2016;52:163–172.
  • Tani K, Tabuchi K, Hara A. Hair cell loss induced by sphingosine and a sphingosine kinase inhibitor in the rat cochlea. Neurotox Res. 2016;29:35–46.

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