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Acta Oto-Laryngologica Volume 137, 2017 - Issue 10
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Research Article

Molecular mechanisms underlying the protective effects of hydrogen-saturated saline on noise-induced hearing loss

Liwei ChenDepartment of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Beijing, China; View further author information
,
Mingkun HanDepartment of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Beijing, China; View further author information
,
Yan LuDepartment of Otolaryngology Head and Neck Surgery, Affiliated Fuzhou First Hospital of Fujian Medical University, Fujian, China; View further author information
,
Daishi ChenDepartment of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Beijing, China; ;Department of Neurosurgery Erlangen, Medical Faculty of the Friedrich Alexander University of Erlangen-Numberg, Erlangen, Germany; View further author information
,
Xuejun SunDepartment of Diving Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, China; View further author information
,
Shiming YangDepartment of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Beijing, China; View further author information
,
Wei SunDepartment of Communicative Disorders and Sciences, University at Buffalo The State University of New York, Buffalo, NY, USAView further author information
,
Ning YuDepartment of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Beijing, China; Correspondence[email protected]
View further author information
&
Suoqiang ZhaiDepartment of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Beijing, China; Correspondence[email protected]
View further author information
 show all
Pages 1063-1068 | Received 22 Feb 2017, Accepted 30 Apr 2017, Published online: 26 May 2017

References

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  • Chen L, Yu N, Lu Y, et al. Hydrogen-saturated saline protects intensive narrow band noise-induced hearing loss in guinea pigs through an antioxidant effect. PLoS One. 2014;9:e100774.
  • Kurioka T, Matsunobu T, Satoh Y, et al. Inhaled hydrogen gas therapy for prevention of noise-induced hearing loss through reducing reactive oxygen species. Neurosci Res. 2014;89:69–74.
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  • Chen XL, Zhang Q, Zhao R, et al. Superoxide, H2O2, and iron are required for TNF-alpha-induced MCP-1 gene expression in endothelial cells: role of Rac1 and NADPH oxidase. Am J Physiol Heart Circ Physiol. 2004;286:H1001–H1007.
  • Mao YF, Zheng XF, Cai JM, et al. Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats. Biochem Biophys Res Commun. 2009;381:602–605.
  • Li J, Wang C, Zhang JH, et al. Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced Alzheimer's disease by reduction of oxidative stress. Brain Res. 2010;1328:152–161.
  • Huang CS, Kawamura T, Toyoda Y, et al. Recent advances in hydrogen research as a therapeutic medical gas. Free Radic Res. 2010;44:971–982.
  • Sun Q, Cai J, Liu S, et al. Hydrogen-rich saline provides protection against hyperoxic lung injury. J Surg Res. 2011;165:e43–e49.
  • Ichihara M, Sobue S, Ito M, et al. Beneficial biological effects and the underlying mechanisms of molecular hydrogen-comprehensive review of 321 original articles. Med Gas Res. 2015;5:12.

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