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Acta Oto-Laryngologica Volume 138, 2018 - Issue 2
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Research Article

CD73 expression in lymph node metastases in patients with head and neck cancer

Magis MandapathilDepartment of Otorhinolaryngology, Head and Neck Surgery, Philipps-Universität Marburg, Germany; ;Department of Otorhinolaryngology, Head and Neck Surgery, Asklepios Clinic St. Georg, Hamburg, Germany; Correspondence[email protected]
,
Mehtap BoducDepartment of Otorhinolaryngology, Head and Neck Surgery, Philipps-Universität Marburg, Germany;
,
Christoph NetzerDepartment of Otorhinolaryngology, Head and Neck Surgery, Philipps-Universität Marburg, Germany;
,
Christian GüldnerDepartment of Otorhinolaryngology, Head and Neck Surgery, Philipps-Universität Marburg, Germany;
,
Marion RoesslerDepartment of Pathology, Philipps-Universität Marburg, Germany
,
Ute Wallicek-DworschakDepartment of Otorhinolaryngology, Head and Neck Surgery, Philipps-Universität Marburg, Germany;
,
Evelyn JahnsDepartment of Otorhinolaryngology, Head and Neck Surgery, Philipps-Universität Marburg, Germany;
&
Boris StuckDepartment of Otorhinolaryngology, Head and Neck Surgery, Philipps-Universität Marburg, Germany;
show all
Pages 180-184 | Received 19 Jul 2017, Accepted 21 Aug 2017, Published online: 22 Sep 2017

References

  • Roth GA, Johnson C, Abajobir A, et al. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016;388:1545–1602.
  • Argiris A, Karamouzis MV, Raben D, et al. Head and neck cancer. Lancet. 2008;371:1695–1709.
  • Allard B, Longhi MS, Robson SC, et al. The ectonucleotidases CD39 and CD73: novel checkpoint inhibitor targets. Immunol Rev. 2017;276:121–144.
  • Bono MR, Fernández D, Flores-Santibáñez F, et al. CD73 and CD39 ectonucleotidases in T cell differentiation: beyond immunosuppression. FEBS Lett. 2015;589:3454–3460.
  • Mandapathil M, Hilldorfer B, Szczepanski MJ, et al. Generation and accumulation of immunosuppressive adenosine by human CD4 + CD25highFOXP3+ regulatory T cells. J Biol Chem. 2010;285:7176–7186.
  • Allard B, Beavis PA, Darcy PK, et al. Immunosuppressive activities of adenosine in cancer. Curr Opin Pharmacol. 2016;29:7–16.
  • Zhang B, Song B, Wang X, et al. The expression and clinical significance of CD73 molecule in human rectal adenocarcinoma. Tumour Biol. 2015;36:5459–5466.
  • Zhi X, Wang Y, Yu J, et al. Potential prognostic biomarker CD73 regulates epidermal growth factor receptor expression in human breast cancer. IUBMB Life. 2012;64:911–920.
  • Leclerc BG, Charlebois R, Chouinard G, et al. CD73 Expression is an independent prognostic factor in prostate cancer. Clin Cancer Res. 2016;22:158–166.
  • Turcotte M, Spring K, Pommey S, et al. CD73 is associated with poor prognosis in high-grade serous ovarian cancer. Cancer Res. 2015;75:4494–4503.
  • Mandapathil M, Szczepanski MJ, Szajnik M, et al. Increased ectonucleotidase expression and activity in regulatory T cells of patients with head and neck cancer. Clin Cancer Res. 2009;15:6348–6357.
  • Mandapathil M, Szczepanski MJ, Szajnik M, et al. Adenosine and prostaglandin E2 cooperate in the suppression of immune responses mediated by adaptive regulatory T cells. J Biol Chem. 2010;285:27571–27580.
  • Wang L, Tang S, Wang Y, et al. Ecto-5′-nucleotidase (CD73) promotes tumor angiogenesis. Clin Exp Metastasis. 2013;30:671–680.
  • Stagg J, Divisekera U, McLaughlin N, et al. Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis. Proc Natl Acad Sci USA. 2010;107:1547–1552.
  • Muller-Haegele S, Muller L, Whiteside TL. Immunoregulatory activity of adenosine and its role in human cancer progression. Expert Rev Clin Immunol. 2014;10:897–914.
  • Lu XX, Chen YT, Feng B, et al. Expression and clinical significance of CD73 and hypoxia-inducible factor-1α in gastric carcinoma. WJG. 2013;19:1912–1918.
  • Wu R, Chen Y, Li F, et al. Effects of CD73 on human colorectal cancer cell growth in vivo and in vitro. Oncol Rep. 2016;35:1750–1756.
  • Ren ZH, Yuan YX, Ji T, et al. CD73 as a novel marker for poor prognosis of oral squamous cell carcinoma. Oncol Lett. 2016;12:556–562.
  • Koszałka P, Gołuńska M, Stanisławowski M, et al. CD73 on B16F10 melanoma cells in CD73-deficient mice promotes tumor growth, angiogenesis, neovascularization, macrophage infiltration and metastasis. Int J Biochem Cell Biol. 2015;69:1–10.
  • Oh HK, Sin JI, Choi J, et al. Overexpression of CD73 in epithelial ovarian carcinoma is associated with better prognosis, lower stage, better differentiation and lower regulatory T cell infiltration. J Gynecol Oncol. 2012;23:274–281.

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