Advanced search
Publication Cover
Acta Oto-Laryngologica Volume 138, 2018 - Issue 5
Submit an article Journal homepage
793
Views
42
CrossRef citations to date
0
Altmetric
Research Article

Presenting symptoms and clinical findings in HPV-positive and HPV-negative oropharyngeal cancer patients

Timo CarpénDepartment of Otorhinolaryngology – Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Correspondence[email protected]
View further author information
,
Anni SjöblomDepartment of Pathology, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; View further author information
,
Marie LundbergDepartment of Otorhinolaryngology – Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; View further author information
,
Caj HaglundDepartment of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; View further author information
,
Antti MarkkolaDepartment of Radiology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; ORCID Iconhttp://orcid.org/0000-0002-9779-1093View further author information
ORCID Icon,
Stina SyrjänenDepartment of Oral Pathology and Oral Radiology, University of Turku and Turku University Hospital, Turku, Finland; View further author information
,
Jussi TarkkanenDepartment of Pathology, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; View further author information
,
Antti MäkitieDepartment of Otorhinolaryngology – Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; ;Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet and Karolinska Hospital, Stockholm, SwedenORCID Iconhttp://orcid.org/0000-0002-0451-2404View further author information
ORCID Icon,
Jaana HagströmDepartment of Pathology, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; View further author information
&
Petri MattilaDepartment of Otorhinolaryngology – Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; View further author information
 show all
Pages 513-518 | Received 24 Sep 2017, Accepted 09 Nov 2017, Published online: 21 Nov 2017

References

  • Mehanna H, Beech T, Nicholson T, et al. Prevalence of human papillomavirus in oropharyngeal and nonoropharyngeal head and neck cancer-systematic review and meta-analysis of trends by time and region. Head Neck. 2013;35:747–755.
  • Lundberg M, Leivo I, Saarilahti K, et al. Increased incidence of oropharyngeal cancer and p16 expression. Acta Otolaryngol. 2011;131:1008–1011.
  • Habbous S, Chu KP, Qiu X, et al. The changing incidence of human papillomavirus-associated oropharyngeal cancer using multiple imputation from 2000 to 2010 at a Comprehensive Cancer Centre. Cancer Epidemiol. 2013;37:820–829.
  • Mork J, Lie AK, Glattre E, et al. Human papillomavirus infection as a risk factor for squamous-cell carcinoma of the head and neck. N Engl J Med. 2001;344:1125–1131.
  • Chaturvedi AK, Engels EA, Pfeiffer RM, et al. Human papillomavirus and rising oropharyngeal cancer incidence in the United States. J Clin Oncol. 2011;29:4294–4301.
  • D’Souza G, Kreimer AR, Viscidi R, et al. Case-control study of human papillomavirus and oropharyngeal cancer. N Engl J Med. 2007;356:1944–1956.
  • Ndiaye C, Mena M, Alemany L, et al. HPV DNA, E6/E7 mRNA, and p16INK4a detection in head and neck cancers: a systematic review and meta-analysis. Lancet Oncol. 2014;15:1319–1331.
  • Seoane J, Takkouche B, Varela-Centelles P, et al. Impact of delay in diagnosis on survival to head and neck carcinomas: a systematic review with meta-analysis. Clin Otolaryngol. 2012;37:99–106.
  • Gillison ML, D’Souza G, Westra W, et al. Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers. J Natl Cancer Inst. 2008;100:407–420.
  • Cantrell SC, Peck BW, Li G, et al. Differences in imaging characteristics of HPV-positive and HPV-negative oropharyngeal cancers: a blinded matched-pair analysis. AJNR Am J Neuroradiol. 2013;34:2005–2009.
  • Dahlstrom KR, Bell D, Hanby D, et al. Socioeconomic characteristics of patients with oropharyngeal carcinoma according to tumor HPV status, patient smoking status, and sexual behavior. Oral Oncol. 2015;51:832–838.
  • Ang KK, Harris J, Wheeler R, et al. Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med. 2010;363:24–35.
  • Fakhry C, Westra WH, Li S, et al. Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. J Natl Cancer Inst. 2008;100:261–269.
  • Ragin CCR, Taioli E. Survival of squamous cell carcinoma of the head and neck in relation to human papillomavirus infection: review and meta-analysis. Int J Cancer. 2007;121:1813–1820.
  • Gorsky M, Epstein JB, Oakley C, et al. Carcinoma of the tongue: a case series analysis of clinical presentation, risk factors, staging, and outcome. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004;98:546–552.
  • Guggenheimer J, Verbin RS, Johnson JT, et al. Factors delaying the diagnosis of oral and oropharyngeal carcinomas. Cancer. 1989;64:932–935.
  • Psychogios G, Alexiou C, Agaimy A, et al. Epidemiology and survival of HPV-related tonsillar carcinoma. Cancer Med. 2014;3:652–659.
  • Rogers SN, Vedpathak SV, Lowe D. Reasons for delayed presentation in oral and oropharyngeal cancer: the patients perspective. Br J Oral Maxillofac Surg. 2011;49:349–353.
  • Lyhne NM, Christensen A, Alanin MC, et al. Waiting times for diagnosis and treatment of head and neck cancer in Denmark in 2010 compared to 1992 and 2002. Eur J Cancer. 2013;9:1627–1633.
  • McIlwain WR, Sood AJ, Nguyen SA, et al. Initial symptoms in patients with HPV-positive and HPV-negative oropharyngeal cancer. JAMA Otolaryngol Head Neck Surg. 2014;140:441–447.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.